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For your reference, here are all of the posts my pawrents wrote about when I was on Metronomic Therapy. Please keep in mind that this was my experience only.
Don’t miss our video interview with Dr. Rosenberg discussing metronomics for canine cancer.
2 November 2009
Thank you Jerry for posting this again – such great information! Mackenzie is going on her 2nd month of this treatment plan and so far she’s doing great! No problems yet. My vet who works with Dr. Rosenberg said that she is using the metronomic on dogs more and more now to fight cancer because it’s proving to be a very effective chemo treatment. Thanks to you and this website, I was able to do my research and determine that this was a good option for us.
Kami (Mackenzie’s Mom)
My sweet golden Mackenzie. She became my angel on Dec 29, 2010 at the age of 8 1/2 although she was always my angel from the time we brought her home. She was diagnosed with osteosarcoma in Sept 2009 and officially became a tripawd (front leg) on Nov 5, 2009. She will be forever in my heart and now she's running free with all of our other tripawd heroes. I love you Mackenzie!
Another post about a new form of Metronomics, done by Dr. Kelly at the Veterinary Cancer Care center in Santa Fe.
Here's a story from the Morris Animal Foundation's 12/10 newsletter about a Metronomic Protocol Study they helped fund. “New Drug Administration Option Improves Treatment Success and Decreases Side Effects.”
Here's a great look at the latest in metronomic therapy by our favorite vet, Dr. Pam Wiltzius.
“Tripawds Ask a Vet Forum: Considering Metronomics“
I just finished researching metronomics for Sammy and here is what I found. Most oncologists prefer meloxicam (Metacam) as the NSAID due to it's wide safety range but a few still prefer piroxicam. There are 5 different chemo drugs that are being tried but the only one with research behind it (so far) for this use is Cytoxan (cyclophosphamide). The main side effect is on the bladder with some dogs getting infections and some getting sterile hemorrhagic cystitis (bleeding and pain without infection). This is rare and usually reversible by stopping the drug. Some oncologists give a low daily dose of a diuretic (Lasix) to try and prevent this but most don't since diuretics can affect the kidneys. My holistic vet recommends cranberry capsules as a way to prevent a UTI. Tazzie took Cytoxan for 2 or 3 months but I had to stop it due to a severe bladder infection (she had a history of bad UTIs so I wasn't too surprised). I kept her on the meloxicam alone and then did artemisinin .
5 March 2011
Thanks for this post and all the helpful links. Tate had an appointment with the oncologist today and he'll be starting metronomics tomorrow, Cytoxan + Rimadyl. He also offered Palladia and we talked through that and we're going to stick with just C + R.
I'm oddly excited about strangling off the blood supply to those evil cancer cells! For the first time, I kinda feel like we're getting ahead on this thing. And Tater Tot's been doing really well recently
Anyway, I just wanted to say thank you for all the great information here.
August 16, 2006 to November 28, 2011
TATE ~ Forever in our hearts.
No, thank you! And best of luck with Tate’s treatment.
Current metronomic protocol information with Dr. Barbara Biller, one of the world’s most respected canine cancer researchers:
19 January 2013
I am so glad I found these posts. This is such helpful information on metronomic chemotherapy . Thank you for posting all of these links.
Paw shucks, you’re so welcome! If you come across other helpful posts elsewhere feel free to share them here. I’m so hoppy you find this useful.
If you’re coping with lung mets, this information from Cadence can help:
According to this Veterinary Partner 360 post:
How this Medication is Used
Some typical situations in which cough suppression with hydrocodone would be helpful include:
- Kennel cough (a usually minor infection leading to bronchitis).
- Collapsing trachea (where the windpipe becomes flimsy).
- “Old dog” bronchitis (a natural part of aging in dogs involves excess mucus production in the lungs).
- Heart enlargement (where the right chambers of the heart become so large that as the heart beats they pinch off the main airways)
These are all conditions where minor secretions or actual tissues are pressing on the lung’s airways and stimulating cough. Coughs that benefit from suppression are typically dry and hacking, often described as sounding as though something is stuck in the throat.
The effect of hydrocodone in a dog is believed to last approximately 6 to 12 hours. It is typically dosed at four times a day usage or less, as needed.
Tripawds members Sassy, Jill the Cat and Jackson have recently switched to chlorambucil for their own metronomic protocols. As a result, we were inspired to learn more about chlorambucil and melphalan by contacting world-renowned metronomic chemotherapy expert Dr. Barbara Biller, Veterinarian and Associate Professor of Oncology at Colorado State University Animal Cancer Center. . . .
A great article about metronomic chemotherapy by oncologist Dr. Joanne Intile: