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Metronomic Chemotherapy for Canine Osteosarcoma and Other Limb Cancers
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26 July 2018 - 10:56 am
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Interesting study published about scientists who researched the effectiveness of metronomic chemotherapy :

https://avmajou…..52.11.1377

Evaluation of metronomic cyclophosphamide chemotherapy as maintenance treatment for dogs with appendicular osteosarcoma following limb amputation and carboplatin chemotherapy

OBJECTIVE To determine the effectiveness of metronomic cyclophosphamide (MC) chemotherapy (primary treatment of interest) with adjuvant meloxicam administration as maintenance treatment for dogs with appendicular osteosarcoma following limb amputation and carboplatin chemotherapy.

CONCLUSIONS AND CLINICAL RELEVANCE Maintenance MC chemotherapy following limb amputation and completed carboplatin chemotherapy was associated with no increase in PFT or OST in dogs with appendicular osteosarcoma. Cystitis was common in MC-treated dogs, and prophylactic treatment such as furosemide administration could be considered to reduce the incidence of cystitis in such dogs.

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26 July 2018 - 1:03 pm
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This article about metronomics was published shortly after the 2018 American Veterinary Medical Association conference

July 16, 2018

AVMA 2018: Metronomic Chemotherapy – Another Treatment Option for Neoplasia

Chemotherapy offers pets with cancer the ability to live longer with better quality of life despite having a terminal disease. However, traditional chemotherapy protocols are not the right fit for every owner, patient, or disease process. A newer option called metronomic chemotherapy offers an alternative treatment, explained cancer specialist Sue Ettinger, DVM, DACVIM (oncology), at the 2018 American Veterinary Medical Association Convention in Denver, Colorado. READ MORE

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28 February 2019 - 2:00 pm
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Just found a couple of interesting studies relating to this topic:

Metronomic Chemotherapy and Cystitis Risk: “Evaluaion of toxicity of a chronic alternate day metronomic cyclophosphamide chemotherapy protocol in dogs with naturally occurring cancer”

, higher cumulative dose and longer treatment duration increased the risk of SHC development with this every other day LDM CYC protocol. Close monitoring and/or prophylactic treatments should be considered for patients receiving LDM CYC over a long period.

Metronomic Chemotherapy and Cats:Evaluation of low-dose metronomic (LDM) cyclophosphamide toxicity in cats with malignant neoplasia.”

Low-dose cyclophosphamide seems to be a well-tolerated option for cats bearing primary or metastatic tumours. Evaluation of toxicity after long-term administration is still needed.

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14 March 2019 - 2:31 pm
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If you live in Northern California and your dog has lung metastasis, you may be interested in this new 1-year clinical trial at UC Davis:

Evaluating a new contrast delivery service in dogs with lung tumors.

What happens in this study
As part of this study, your dog will receive the same diagnostic tests and care that any other dog with lung tumors presented to the UC Davis VMTH would receive. If you agree to enroll your dog in the trial, your dog will be randomly assigned to a particular device which will be used to inject dye into the lung tumor; additionally, your dog will undergo a contrast CT scan while under anesthesia. After the CT scan, your dog will be taken to surgery as per standard of care for lung tumors.

The drawback is there is no medical benefit to participating, but the bonus is that if you do you will be helping to advance the science of detecting and treating those awful “lung mints,” as a dear member used to call her two mets (“Boris” and “Natasha”):

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