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Managing Lung Metastasis in Dogs and Cats with Limb Cancer
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The Rainbow Bridge



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26 July 2018 - 10:56 am
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Interesting study published about scientists who researched the effectiveness of metronomic chemotherapy :

https://avmajou.....52.11.1377

Evaluation of metronomic cyclophosphamide chemotherapy as maintenance treatment for dogs with appendicular osteosarcoma following limb amputation and carboplatin chemotherapy

OBJECTIVE To determine the effectiveness of metronomic cyclophosphamide (MC) chemotherapy (primary treatment of interest) with adjuvant meloxicam administration as maintenance treatment for dogs with appendicular osteosarcoma following limb amputation and carboplatin chemotherapy.

CONCLUSIONS AND CLINICAL RELEVANCE Maintenance MC chemotherapy following limb amputation and completed carboplatin chemotherapy was associated with no increase in PFT or OST in dogs with appendicular osteosarcoma. Cystitis was common in MC-treated dogs, and prophylactic treatment such as furosemide administration could be considered to reduce the incidence of cystitis in such dogs.

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26 July 2018 - 1:03 pm
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This article about metronomics was published shortly after the 2018 American Veterinary Medical Association conference

July 16, 2018

AVMA 2018: Metronomic Chemotherapy - Another Treatment Option for Neoplasia

Chemotherapy offers pets with cancer the ability to live longer with better quality of life despite having a terminal disease. However, traditional chemotherapy protocols are not the right fit for every owner, patient, or disease process. A newer option called metronomic chemotherapy offers an alternative treatment, explained cancer specialist Sue Ettinger, DVM, DACVIM (oncology), at the 2018 American Veterinary Medical Association Convention in Denver, Colorado. READ MORE

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28 February 2019 - 2:00 pm
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Just found a couple of interesting studies relating to this topic:

Metronomic Chemotherapy and Cystitis Risk: "Evaluaion of toxicity of a chronic alternate day metronomic cyclophosphamide chemotherapy protocol in dogs with naturally occurring cancer"

, higher cumulative dose and longer treatment duration increased the risk of SHC development with this every other day LDM CYC protocol. Close monitoring and/or prophylactic treatments should be considered for patients receiving LDM CYC over a long period.

Metronomic Chemotherapy and Cats: "Evaluation of low-dose metronomic (LDM) cyclophosphamide toxicity in cats with malignant neoplasia."

Low-dose cyclophosphamide seems to be a well-tolerated option for cats bearing primary or metastatic tumours. Evaluation of toxicity after long-term administration is still needed.

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14 March 2019 - 2:31 pm
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If you live in Northern California and your dog has lung metastasis, you may be interested in this new 1-year clinical trial at UC Davis:

Evaluating a new contrast delivery service in dogs with lung tumors.

What happens in this study
As part of this study, your dog will receive the same diagnostic tests and care that any other dog with lung tumors presented to the UC Davis VMTH would receive. If you agree to enroll your dog in the trial, your dog will be randomly assigned to a particular device which will be used to inject dye into the lung tumor; additionally, your dog will undergo a contrast CT scan while under anesthesia. After the CT scan, your dog will be taken to surgery as per standard of care for lung tumors.

The drawback is there is no medical benefit to participating, but the bonus is that if you do you will be helping to advance the science of detecting and treating those awful "lung mints," as a dear member used to call her two mets ("Boris" and "Natasha"):

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15 February 2020 - 8:20 am
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Great info by Dr. Sue Ettinger, author of The Dog Cancer Survival Guide :

Giving Your Dog Chemotherapy at Home, Safely

Have to give your dog chemotherapy at home? Dr. Susan Ettinger, DVM, Dip. ACVIM (Oncology) has tips to keep you and your loved ones safe.

I get a lot of questions about how to give your dog chemotherapy at home, safely (for example, during metronomic chemotherapy).  In this article, I’m going to go over my answer for some of the most frequently asked questions. You’ll also find more information in our comprehensive book The Dog Cancer Survival Guide.

Is my pet safe to be around?

Yes, your pet is safe to be around after treatment. Being around family members – human and other pets in the home –  is an important part of your pet’s life. Enjoying normal activities together – including petting, hugging, and kissing – are all safe.  However, the excretions (urine, feces, vomit) from pets receiving chemotherapy can be hazardous.  It is therefore important to minimize our exposure to chemotherapy, and common sense precautions should be taken. READ MORE

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25 January 2021 - 9:13 pm
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WOW! We just tuned into the best webinar by the University of Wisconsin School of Veterinary Medicine's clinical oncology department. Called "Inside the SVM: Helping Pets Fight Cancer," it was a fascinating one hour talk about clinical trials and a new treatment. The reason why we are posting it here is to spotlight a new cancer therapy treatment that can be used to FIGHT LUNG METASTASIS! 

The Radixact radiotherapy system is a type of radiation treatment that is more precise than any other therapy in existence at the moment. Formerly known as "image guided, intensity modulated radiation therapy (IG-IMRT)" it came online last October. Developed by UW, it can even TREAT LUNG METS! It does depend on the type of mets it is actually possible to successfully obliterate lung mets in a pet with cancer metastasis. Here is what UW radiation oncology section chief Dr. Forrest has to say about it in response to our question:

We'll post a full story about this new treatment in Tripawds News soon. Watch the entire discussion from the beginning to learn more about Radixact for pets.

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26 January 2021 - 4:55 pm
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Have not watched the whole video yet, but from your brief comments... WOW!!!   To have progress and hope in the treatment of mets is a huge breakthrough!!!!

Thanks for your non stop efforts in bringing  us every cutting edge possibility  as it devrlops.

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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26 January 2021 - 6:53 pm
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Yes it IS a huge breakthrough! I'm so excited that this technology is taking place, it brought tears to my eyes to think that there is now an option like this. In the presentation, they also talked about a targeted immunotherapy treatment that can attack not just bone tumors but metastasis throughout the body at the same time! This is real progress in the fight against this piece of crap disease 😉

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Lori Kroening
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10 May 2021 - 2:12 pm
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Thank you SO MUCH for sharing the video from UW! My dog (whose osteosarcoma has metastasized to her liver) will have a CT scan there next week. Depending on the results, the following week she will have three radiation treatments using this new technology!

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10 May 2021 - 3:14 pm
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Oh Lori! Paws crossed she can participate. We would LOVE to hear more so please come back and tell us how things went. Thanks for sharing!

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Lori Kroening
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10 May 2021 - 5:30 pm
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I will definitely do so! The radiation oncologist I spoke with was very patient and easy to talk with. He said if Schatzi ends up getting the treatment, she will be only the second dog ever to receive it! That's so amazing. They're doing incredible things at UW.

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1 October 2021 - 1:21 pm
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Are you within driving distance to Colorado State University's Flint Animal Cancer Center? If your dog has ostesoarcoma lung metastasis, a new clinical trial may help:

Modulating the Tumor Microenvironment in Metastatic Osteosarcoma: Palladia/Losartan/Ladarixin Combination Therapy

PURPOSE OF THE STUDY:

To investigate the safety and biologic activity of combined treatment with losartan, Palladia, and ladarixin in dogs with metastatic OS to the lungs, assess the overall response rate and duration of response to this treatment, and determine the effects of treatment on tumor genetics and the immune system

PRIMARY ELIGIBILITY CRITERIA:

  • Dogs that have had surgery to remove their primary tumor and a confirmed diagnosis of osteosarcoma with measurable metastatic disease in the lungs on chest X-rays
  • Adequate blood work
  • No prior treatment for lung metastasis
  • No metastatic disease anywhere besides the lungs
  • Cannot have previously received immune-suppressive medications for any condition
  • Pets must come to CSU for all visits related to the clinical trial

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