TRIPAWDS: Home to 11949 Members and 1382 Blogs.


Post-Amputation Side Effects in Dogs and Cats

Amputation. The word makes pet parents nervous, and it’s easy to understand why.

prevent amputation side effects in dogs and cats

There’s the once-unfathomable idea of watching your pet become a “tripod.” And then there are the possible complications that can result from this procedure.

Like all surgeries, amputation has risks. They can range from bruising and swelling to fatal blood clots during surgery.

But as other Tripawd pawrents have reported, amputation surgery side effects are few and far between. According to the American College of Veterinary Surgeons:

“the complication rate is very low. The most common complications, which occur in less than 5% of cases, are wound infection, wound breakdown, and accumulation of fluid underneath the surgical site (i.e., seroma formation).”

The first step you can take toward reducing your pet’s risk of post-amputation surgery problems is by learning how to find the best vet for amputation surgery.

Tripawds Doc Discusses Post-Amputation Side Effects

Tripawds recently talked about amputation surgery risks with one of our biggest supporters, Dr. Pam Wiltzius of River Road Animal Hospital in Puyallup, Washington. Dr. Wiltzius isn’t just a vet who works with dogs facing amputation surgery, she also has firsthand experience with amputation because her beloved dog Tazzie went through the process herself after being diagnosed with bone cancer.

We asked Dr. Wiltzius if she could tell us about the most common amputation surgery risks. Here’s what she had to say:

A Primer on Post-Amputation Surgery Side Effects


A seroma is an abnormal accumulation of fluid that occurs after amputation surgery. After a leg is removed, body fluids can build up at the area of least possible resistance, the surgical site. Some veterinarians will insert a drainage tube prior to surgery to encourage fluid drainage, some won’t. Before surgery, ask your vet what their preference is.

If you notice a large pocket of fluid building up around the incision, accompanied by some dripping, your Tripawd may have a seroma. Seromas can happen after any invasive procedure but are most common with amputation surgeries. Although seromas look terrible, usually they are harmless and can be often be resolved with a pressure bandage and/or draining in the office.

When to See Your Vet

If a seroma is present, you’ll see a clear to light pink fluid dripping from the incision area. The fluid is clear, without any cloudiness.

The best way to tell if your dog or cat needs an in-office vet visit is to watch how quickly the fluid is dripping. If the fluid is dripping faster than one drop per second, call your vet. Before calling, take note of the color and consistency. If the fluid is viscous or appears as dark to purple in color, your Tripawd may have an infection or an untied blood vessel and your vet should know about this. When infection is present, the bacteria can destroy tissues around the sutures and cause the sutures to come undone. In a worst case scenario, a second surgery will be required to eliminate the diseased tissue and close up the area.

How to Prevent Seromas

Seromas are often linked to excessive activity immediately after surgery. One of the best ways to prevent them is to keep your pet calm, quiet and confined for a few days. Dr Wiltzius also advises using a pressure bandage after surgery.

If there is any sign of a seroma, call your veterinarian immediately.

Phantom Limb Pain

Phantom limb pain is another common side effect after amputation surgery. Again, it’s a side effect that can be controlled, and even prevented.

Phantom pain happens when a severed nerve “thinks” that the limb is still attached to the body. The nerve is trying to control a limb that doesn’t exist.

Your Tripawd may have phantom pain if she:

  • Constantly looks behind her to see if the leg is there
  • Attempts to move the area where the limb was
  • Randomly cries out with loud, sharp shrieks
  • Has light muscle twitching in the incision area
  • Shakes or pants (which could also indicate general post-op pain)

Phantom pain is a normal complication and many amputee pets get it. Although time is the best thing that can help the severed nerve to heal, you can take steps to alleviate this pain.

Gabapentin is a human drug that is also used in animals. The National Institute of Health says:

“Gabapentin is used to help control certain types of seizures in patients who have epilepsy. Gabapentin is also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles). Gabapentin is in a class of medications called anticonvulsants. Gabapentin treats seizures by decreasing abnormal excitement in the brain. Gabapentin relieves the pain of PHN by changing the way the body senses pain.”

Many human and animal medical studies have shown that if you start Gabapentin just one day before amputation and continue for a week afterward, it can eliminate or reduce phantom limb pain. Even if your pet doesn’t have Gabapentin prior to surgery, it can still be used post-op. Most pets take two to 3 times daily for best results. This drug is available in generic form, which is far less expensive.

Gabapentin is a newer pain relief option in veterinary medicine, and many vets are still unfamiliar with it. If yours doesn’t know about this important drug, ask them to consult with a veterinary pain management specialist from the International Veterinary Academy of Pain Management.

Post-Surgery Blood Clot Risk

Blood clots are the least common post-amputation surgery side effect and very rare. Unfortunately we have seen them happen here at Tripawds, so it’s important to be aware of the risk.

According to the Merck Veterinary Manual:

“A thrombus is an aggregation of blood factors that may form when the blood flow in the arteries or veins is impeded. It frequently causes vascular obstruction at its site of origin. The thrombus can be classified based on its location and the syndrome it produces (eg, venous thrombosis in large animals associated with prolonged venous catheterization, pulmonary arterial thrombosis associated with heartworm disease in dogs). All or part of a thrombus may break off and be carried through the bloodstream as an embolus that lodges distally at a point of narrowing. Embolization can also occur when foreign material (eg, bacteria, air, fat, catheter piece) is carried into the bloodstream.

Thrombi and emboli can be septic or nonseptic. Poor injection or catheterization techniques and inferior catheter material can all result in vascular thrombosis. However, life-threatening vascular thrombosis is more commonly encountered in patients with underlying disease states that result in coagulopathies, such as systemic inflammation, or endotoxemia. . . .

If left untreated or uncontrolled, these hypercoagulable conditions can result in hemorrhagic diathesis and/or disseminated intravascular coagulation (DIC), a life-threatening disorder of hemostasis with deposition of microthrombi with concurrent hemorrhage.”

Unfortunately blood clots can only be diagnosed when a MRI is performed, and many times they happen before anything can be done about them. Before surgery, talk to your vet about your pet’s risk of blood clots during and after surgery.

Many thanks to Dr. Wiltzius for her pawesome perspective on canine amputation and bone cancer.

Read more tips about canine amputation from Dr. Wiltzius:

More Recommended Reading:

39 Responses to “Post-Amputation Side Effects in Dogs and Cats”

  1. I pick up my 7 year old baby boy today at 11:00. This boy, the love of my life is a rottie who rescued me when he was 6 months old. He “had” bone cancer and is now a special Tripawds like all the other wonderful babies I’ve been reading about these past few days. All of you and your Tripawds have helped me so much with your stories. I don’t have to tell you how difficult this decision is with so little “expected”. Thank you for helping me believe its a good thing and understand more why. I’m home finishing this post, Jagen is sleeping. He walked into the vets exam room after crying for me in the kennels as happy and normal looking as if he’d been boarding there. I’m amazed how he can manage. I’ve got to get some weight off of him. It is the right decision. Soooo, I’m on my way with my boy on this Tripawd journey. Never did I ever imagine this. I’m overly blessed by my boy and the support I see for us on this site. All of you and your furbabies have made a big difference in mine and Jagens life. Today, Day 1

  2. My dog had her rear left leg amputated on Monday and she has swelling in her right front and rear leg. Is that normal?

    • Christine please let your vet know about the swelling. Since we don’t know your dog and we aren’t vets, we can’t give you advice. Usually post-op swelling is just body fluids that are working their way around the body since there’s no leg to go to, but to be safe please call your vet OK? And hop over to our discussion forums so we can better assist you in your journey. We’ll be waiting!

  3. My mini schnauzer had his right front leg amputated 9 days ago and he seems to have a twitch, what does this mean?

    • Twitching is a normal sign of the nerves mending. Please visit the forums and blogs for much more help, or download the e-books for fast answers to most common concerns. Start here for help finding the many helpful Tripawds Resources!

  4. Susan Uttendorfsky June 25, 2017 at 2:39 pm

    My dog Sophie, 4yo, had her front leg amputated after a lawnmower accident. That was about 10 months ago. She still has phantom pain occasionally. But my main question is, whenever she’s standing, she’s almost constantly pulling the stump upward with her shoulder muscles (like a person would shrug with one shoulder). It seems to ache or strain in some way with no leg there to support the shoulder. Any ideas would be appreciated. I have not tried bandaging (like with an Ace) to support the stump or anything…

  5. My rottie Digit had her left from leg amputated 2 week ago after successfully holding on metastasis from Bone Cancer for over a year. We did Stereotactic radiation to save her leg and after 9 months she sufferd a pathological fracture at the tumor site. After a few months of wearing a brace we had no choice as the fracture became worse. Shes done really really well, but now two weeks in and suddenly her rear right leg is swollen at the ankle and while it doesnt seem painful, today she seems less willing to get up and move around. We are going to the vet tomorrow to have her staples removed, however i am always nervous about bad news. Is it common for a large breed dog to suffer some edema on another leg from the added stress of recovery, learning to walk again, etc? Im icing it and keeping her calm today. She is already on anti inflammorty meds, etc. We have covered every base there, so im just curious about this as a physical response to the change in gait. Thanks for any feedback

    • Best wishes for Digit! With the stitches coming out, it’s time to focus on rehab, core conditioning, weight management, balance work and strengthening exercises. (Walks do not build strength, only stamina.) Please download Loving Life On Three Legs for lots of helpful tips and how to videos, or consider consulting with a certified rehab vet/tech for a professional evaluation and DIY exercises you can do at home. She may even be eligible for reimbursement from the Tripawds Foundation Maggie Moo Fund.

  6. Our beloved Rottie, Bodhi, is almost 9 days post-op. He had his front right leg amputated due to pretty serious bone loss from bone cancer. We were completely blindsided by the news he had cancer. We thought it was a sprained ankle because he was only limping a little. I’ve been through a lot of emotion with the amputation and have struggled with knowing if we did the right thing. There was no visible masses in his lungs so we felt like he would have good quality after he healed from his amputation. I’m still not very clear on his life expectancy. I think he is healing well but now he seems to have phantom pains. He has been crying a lot, not wanting to go outside to the bathroom. However he seems to be getting around okay and very affectionate. I noticed his back right leg looks odd when he is hopping along. Maybe it’s hurting? I’m terrified that he is still in some kind of unseen pain. He is really a family member to us and we just are so heartbroken over the whole ordeal.

    • Lindsay I’m sorry to hear about Bodhi. Please come to our Discussion Forums so our whole community can help OK?

      It does sound like he’s experiencing some kind of pain (affection can sometimes be confused with clinginess, which is a pain indicator). Have you talked to your vet? Or a certified rehab therapist? It would really help Bodhi to have that pain managed so he can get along with loving life. Here’s a post that may help explain why appropriate pain management is so important.

      Best wishes to you both. Please keep us posted.

  7. Our Boxer dog “Rocky” was in an accident and had to have his back leg amputated. The accident happen 8 days ago, and they amputated 6 days ago. He has been at the vet the whole time with us visiting daily. Each day they would tell us he could come home the next day, but each day they would say they needed to keep him and monitor him longer. We went to see him yesterday and they said he had nercosis and they were going good to have to do another surgery and replace some stitches. They called me this morning to tell me my dog had crashed during the night…come to find out they wouldn’t let us see him because they didn’t put a colar on him and he had chewed the stitches out and bleed alot..then they only bandaged it but nothing else and during the night he chewed the bandages off and hit his artery and bled out….

    • Oh my gosh you guys, we are heartbroken to read this. Please, if there’s anything we can do to support you, let us know OK? You’ve been through so much, our heart goes out to you.

  8. Have a 8-10 month old pit/mix named Charlie! He had a bad break when we got him so his front leg had to be amputated. He seems to be healing nice, but what’s seems to be a bruise has formed 3 days after his surgery. Took him.back to the vet thinking maybe something wasn’t tied off correctly but was told not to worry. I guess I can’t help it! It is spreading and I’m still concerned. It doesn’t feel like there is any liquid underneath the skin, but I’m not 100% sure what I’m looking/feeling for.

  9. my 3 weeks old puppy broke her leg because it was stuck on their cage so that i will abble to cut her leg. but now it became bloated what are the possible cures that can i apply to her leg?

  10. Kaycee is a chihuahua/terrier mix and was rescued 3/26/16. Previously she was hit by a car and Feb 10, had her left hind leg amputated. We have only had her for a few weeks, but the last week, she has become extremely lethargic, sleeps all day and night, does not want to walk or play and occasionally shrieks when picked up. I am getting no tail wagging or excitement when I walk in the door – except to want and lay by my feet. Her appetite is good and bowels are good. I think she is in pain and our Vet put her on Tramadol for pain and Prednisone for anti-inflamatory. Its only been 3 days of meds, but I see no difference in her sad behavior. Is this behavior indicative of pain for a tripawd?

    • Kaycee is so lucky to have you! It does sound like she’s in some kind of pain and I’m not really sure how Pred will help with that, most vets will give a NSAID for anti-inflammatory. I’m not a vet, so take that for what it’s worth. But, I would definitely want her to see a pain management expert. Here’s a blog post that talks about pain management and how to find a good pain management/rehab vet. Best wishes, and please keep us posted in our Forums, we’re here to help.

  11. My dog Abby had soft tissue sarcoma last year and had her front right leg amputated. She healed really good but till this day she is always licking where her leg used to be. I was wondering if this is normal or what the signs are that she is doing this. Thank you so much!!

    • Justine that could be a pain indicator of some sort. Take note on when it occurs, how often and for how long, what other symptoms if any are happening (tiredness, lack of appetite, cliniginess, etc) and let your vet know.

  12. My Reighnee broke her leg badly as a puppy. Had surgery right away. Then horrible staff infection when they changed her cast 2 weeks later. In 3 days her leg rotted off inside the cast.:( Another surgery. .removed hip etc to stop infection from spreading. . Perfect healthy happy baby for the past 5+ years. . This week she keeps looking at her back side.. walking funny..not eating. .not barking. .playing with her toys. Could her amputation be hurting after 5 year’s? ? Worried Mommy 🙁

    • Oh poor pup. It sounds like she is in pain, I would have her checked out by a vet who understands pain management in Tripawds. Join our Discussion Forums so we can better help you as a community OK?

  13. Recently had to put down our Mini-schanzer after complications following a rear leg amputation. Vet told us he had a severe systemic infection and strongly suggested that we put him down. I feel very guilty that I listened to the vet. I should have given him more time. Should have taken him some food and A leash. If he wanted to eat and take a walk, I should have taken him home. To all those out there. Don’t be so abrupt and quick with your decision
    to put your dog down on the suggestion of a vet Forgive me Jack. I miss you every day!

  14. My dog had his front limb amputated 10days ago. About 85% of his wound his healing fast but there is a hole that is open and keeps draining. He is under vet care. He’s taking antibiotics and we apply sulfadine creAm as prescribed. I’m concerned and the vet tells me that it will heal on its own once new healthy skin tissue starts to form but because of the infection he had pre surgery that was septic is what is causing it to drum and not close. I’m skeptical. Has anyone else experienced this?

  15. my 3 month old puppy recently underwent surgery to remove her left hind leg due to a broken leg the vet couldnt set. she is acting like her puppy self but shivers a lot and im worried about infection its not oozing or anything its swollen still her surgery was march 18th 2014 its really red under the wound dont have a funny odor what things should i look out for other then that

  16. Finn got his rear leg amputated tuesday. He peed before we took him out of the clinic (thursday), but hasn’t peed since (it’s saturday). Pee pads weren’t working, so we built a ramp so he could go in the front yard, still nothing. There is so much snow/slush/mud here yet so there is a really limited area where he can go. He was used to going in the back yard but there is a lot of snow and muck there and I don’t want him to fall. Do you think he is holding out because he is used to going in the back? I am getting really worried that there is nerve damage or something. Do you have any advice, do you think he will just go when he has to go?

    • Hi guys, I’m so sorry that you’re having difficulties. It’s probably nothing serious but at this point you really should go see your vet asap. Usually a dog just needs help getting things moving to get back to being regular. Please call your vet and then come to our discussion forums and let us know how he’s doing. Good luck!

      • Well we had to get him out moving and take him to a more “private” place for Finn to do his business! What a relief!! Now he has kennel cough and is coughing up white foam. The vet tells me the antibiotics he is on should get rid of that. I pray he pulls through this cold and continues healing from the amputation.

  17. My 13 yr.old cocker spaniel has squamous cell carcinoma in his foot the mass was removed 6mos.ago and has returned should I have his leg amputated.I am so afraid because of his age he might die.

    • Hi Louise, we understand your concern. You’ll receive much more advice from members in the discussion forums. Every dog is different, but age doesn’t really matter. If your dog is otherwise fit and healthy, he should do well on three legs. Only you and your vet can make this decision, and while we have heard of it happening, it is very rare for a dog not to survive surgery. You will find plenty of success stories about senior dogs loving life on three legs in the forums.


  1. Tripawds Gear » Farabloc EMF Shield Phantom Limb Pain Relief for Dogs and Cats - February 27, 2018

    […] your dog or cat suffers from phantom limb pain after amputation surgery, consider trying Farabloc, a holistic pain-relief alternative to prescription drugs like […]

  2. Tripawds » Dog Amputation Seromas: Definition, What to Look For, Photos - June 7, 2016

    […] Post-Amputation Side Effects in Dogs […]

  3. Protect Dogs Surgery Incision Help Heal with Anxiety Wrap » Tripawds Gear » Three Legged Dog Cancer Amputation Surgery Product Reviews Hel - July 1, 2014

    […] shirts for dogs. Ask your vet about how compression bandgaes can help promote healing and prevent seromas. And consider the links below for more information about the Anxiety […]

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Tripawds Blogs is brought to you by Tripawds.