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Lung tumor and Palladia?
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Crossing the rainbow bridge
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26 April 2013 - 8:07 pm
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Our 12 year old boxer- shepherd mix Daisy was diagnosed with osteosarcoma in her front left leg last February and underwent amputation surgery on March 7, 2012. All chest rads have been clear until last week when she coughed up some phlegm with blood in it. We had CT scan which confirms large tumor in her accessory lung lobe and very enlarged lymph nodes around the heart. Oncologist is not recommending surgery but said Palladia may offer some hope. At this stage they are not sure if it is a primary lung tumor or an unusual metastasis of the osteosarcoma. Does anyone have Ny experience with a lung tumor and Palladia after osteosarcoma treatment?
Thank you,
Alicia & Daisy

The Rainbow Bridge



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26 April 2013 - 8:46 pm
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Hi Alicia, thanks for joining us. That’s pretty amazing about how well Daisy has done! I’m sorry about the nasty lung met, I know that kind of news is just heartbreaking.

Did your onco talk about metronomic chemotherapy or a lobectomy? We recently had a pup here, Jabba, who had a lung lobectomy to get rid of a met and it went every well. Unfortunately the cancer came back faster than anyone wanted but otherwise he bounced back quickly from the surgery. Usually this works if there is just one tumor, that’s what Daisy’s sounds like?

There is a lot of info here about Palladia during lung metastasis, I know lots of members have tried it and can give you better feedback than I can. Also do a search and you’ll see lots of stories too.

We’re glad you found us. And I want to CELEBRATE Daisy’s one year of kickin’ cancer’s butt! That’s pretty amazing. I hope that she gets lots more hoppy ampuversaries too and whatever treatment you choose keeps the mets away.

It's better to hop on three legs than to limp on four.™
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Crossing the rainbow bridge
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26 April 2013 - 9:43 pm
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Thank you so much for your kind words. We initially considered the lobectomy but our oncologist advised against it because her lymph nodes are so large. She didn’t feel the risk was justified and She feels it I better to get started on the Palladia ASAP.

The Rainbow Bridge



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27 April 2013 - 8:15 am
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Sounds like your oncologist is really great, it’s always good to hear when people are presented all the options.

It's better to hop on three legs than to limp on four.™
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27 April 2013 - 9:32 am
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Hi Alicia and Daisy! First of all, congratulations on over ahead as a victorious tripawd:-) :-) Sounds like your Mom has done a great job of taking care of you! ‘Bet you havebeen spspoiled and loved on like crazy too! Being a tripawd certainly has it’s perks!

As already mentioned, there is plenty of info. On the site about Palladia. ALSO lots of info. on treating with complimentary alternatives too. You’re doing a good job of researching and implementing a comprehensive plan for your Daisy.

Just curious, what has been your plan of action for keeping Daisy so happy and healthy….did she do chemo….supplements….special diet? Clearly being surrounded by lovehas been the best therapy:-) Daisy is a fighter and strong! You go girl:-) :-) :-)

Any pictures? We LOVE pictures:-) :-) :-)

Let us kowknow how you are proceeding and look forward to yoyour updates.

Holding you and Daisy safely in our hearts, Sally and Happy Hannah

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

krun15
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27 April 2013 - 10:47 am
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Hi Alicia,

Welcome to the forums, I’m glad you came over..I was one of the people in the chat room the other night.

I have not use palladia- but I thought of a web-site you might check out: Rosie’s Road.  Rosie is a quad-lab who is fighting mast cell cancer.  But she took palladia for a long time with success.  There might be some info there that is useful to you.

Looking forward to learning more about Dasiy (and you!).

 

Karen

Perth, Western Australia
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28 April 2013 - 5:39 am
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Hi Alicia and Daisy,

Congrats on Daisy doing so well for so long after diagnosis – always awesome to hear such news.
I have recent experience with Palladia and lung mets (well, not me personally!) … my dog Peda ;)

She was diagnosed with osteosarcoma June 2012, with surgery shortly after. She has continued along quite well – but in March this year a single lung met was diagnosed (on X-ray).

Her oncologist and I discussed options and decided that Palladia was worth a shot. (I had some experience with it previously with another dog at home who had a tumour in her jaw). We started treatment on the assumption that it is a lung met (so the primary was osteosarcoma) and that while no other mets were visible on the X-ray, it doesn’t mean that they weren’t there (possibly just too small).

She started on 75mg Monday, Wednesday and Friday. She tolerated it fairly well, although we dropped the dose slightly to 60mg within 2 doses because she had a bit of a runny tummy. We also added in Zantac and that really helped. Weekly blood tests were also needed.

She did well on it for about 4 weeks, but then developed some quite major swelling in her limbs and face (and to be able to see a sharpei is swollen means they are really really swollen!!) We don’t know if it was vasculitis because of the cancer or because of the Palladia. (We also do not know definitively that it was vasculitis (need to biopsy tissue to tell) but ruled out a range of other things it could also be.

We stopped Palladia (as soon as she became unwell) and had a very rough few weeks – high doses of steroids were needed and she was in respiratory distress at night for nearly 10 days.

However, as she is laying by my side snoring at the moment, I can say I am glad we persevered through the weeks of no sleeps (she was having good days while recovering but the nights were terrible).

Now – I say very carefully, that we do not know what caused the reaction – and I cannot say it was Palladia. Vasculitis is a reaction that may occur with Palladia – but dogs with cancer can also have it.

We have decided to no longer treat Peda’s lung mets with palladia and we are looking after her and keeping her comfy. She is doing really well – and is even more spoilt than before if that is possible. We decided it wasn’t worth putting her through the risk of another potential reaction from the drugs.

I had a reasonable idea of issues that can crop up with Palladia (although I didn’t know about vasculitis) – but still thought it was worth a go. I don’t regret it (even though she was desperately unwell for 10 days – we do not know for certain it was Palladia). It is worth having a look through forums for other Palladia stories (and Rosie’s story is great).

If you do decide to go ahead, make sure you have regular blood tests (weekly for the first 4-6 weeks) and don’t be afraid to reduce doses if needed. We actually shifted to a dosage being given every 2.5 to 3 days than every 2 days and that seemed to suit her better.

Good luck – and if you have any questions, I’m happy to help answer if I can.

Kirsty and Peda

Virginia




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28 April 2013 - 4:50 pm
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Kristy and Pedada….Just wanted to say we are sending you best wishes as well as continued best wishes for Alicia and Daisy.

It was very kind of you to take time to enlighten all of us by updating your experience.

I know Peda is thoroughly enjoying being byyour side and being immersed in love and treats:-) :-)

Holding you safely in a healing place in our hearts. Please, all of you, keep us posted, Sally and Happy Hannah

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

Sydney, Australia
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28 April 2013 - 4:52 pm
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We only had Magnum on Palladia for 1 month.  X-rays showed only a minor increase in the growth of one of her 3 lung mets in that time.  But she had GI issues and we stopped it (plus she had the added complication of mets to other bones). 

From what I saw of Palladia I think it could be a good drug to slow down lung mets but my advice would be to make sure Daisy is taking meds to protect her tummy from day one.  And watch her closely for signs of tummy upsets.

 

Karen and Spirit Magnum

Magnum: 30th May 2002 to 5th May 2012. Lost her back left leg to osteosarcoma on 5th Sep 2011. Lung mets found on 20th Mar 2012 but it was bone mets in the hip that ended her brave battle. Magnum's motto - "Dream as if you'll live for ever, live as if you'll die today" (James Dean). Loyal, loving, courageous and spirited to the end. My beloved heart dog, see her memoirs from Rainbow Bridge ...... http://princess.....pawds.com/

Crossing the rainbow bridge
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30 April 2013 - 11:04 pm
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Thank you everyone for the very helpful input and information. Daisy had her first Palladia treatment last night and her oncologist also prescribed an anti-nausea medication for her to take daily. Night one was peaceful and today she ate more than she has in a long time :-) . We have a follow up appointment next Monday for CBC and urinalysis. Sally, Happy Hannah, Kirsty and Peda – sending love your way for continued health and happiness. Those of you with loved ones who have crossed the rainbow bridge – thank you for sharing your experiences!

For those of you who asked how we made it this far – the only change we made post-amputation was to add K9 immunity 2 times per day. Our oncologist told us there was no evidence that certain diets help with osteosarcoma so she continued on dry kibble with a dose of glucosamine for her joints (she had TPLO surgeries at 4 years & 8 years). I honestly think we were just lucky to have such a determined little dog. She started going down the stairs less than 4 weeks after surgery and we got her a front wheel cart so we can do laps at the park :-) .

Love,
Alicia & Daisy

The Rainbow Bridge



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1 May 2013 - 9:11 am
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I’m so glad to hear things are going well! We’d love to hear more about your treatments and Daisy’s life so don’t be shy!

It's better to hop on three legs than to limp on four.™
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Virginia




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1 May 2013 - 9:55 am
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You’ve started a plan and that’s great! You are a very diligent Mom and Daisy sure has a lot of things going in her favor:-)

‘May have misunderstood………..so Daisy had no follow-up chemo after amputation?? With…or without… she is a victorious little lady and is coinuing on a journey of great successes:-) :-) :-)

Keeping all paws crossed..YAY DAISY AND ALICIA:-) :-) :-)

Sally and Happy Hannah

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

Crossing the rainbow bridge
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1 May 2013 - 8:38 pm
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Hi Sally,

sorry I misunderstood – yes Daisy did have chemo post-amputation – 4 doses of carboplatin approx. 3 weeks apart. We did also do metronomic protocol for about 3 months. We stopped because she started urinating all over the house, drinking a ton of water, couldn’t settle down and generally seemed unhappy. Despite no evidence of cystitis, our oncologist recommended we stop. After weeks of tests, ultrasound, etc. we determined her thyroid was through the roof (her dose had never been adjusted post-amputation) and that was likely causing all of her issues. Because it took so long to figure everything out, we never started back on the metronomic. I’m now feeling guilty, wondering if we had stayed with it – would we have prevented the lung mets?

A & D

Virginia




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1 May 2013 - 9:34 pm
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Thanks for taking rime to pass on alll the info.

Now, you have to listen to “Auntie Sally” on this—–and it’s easier said than done———do NOT…..do NOT spend one moment second guessing. Your Daisy is by your side right now because of all the wonderful care you are providing:-) :-)
Had she has problems with metronomics as some have, you would have been beating yourself up for that. Had she had problems with the chemo….bingo..ban go..same routine of beating yourself up

Now, I can give advice on this because I’m very skilled at second guessing:-) :-) Everybody’s gotta’ be good at something!:-) :-)
Daisy was having issues, even though it didn’t appear to be related to the metro. ‘Pretty sure under those circumstances, had you co tinued, it would would have definitely compromised her health further. I guarantee you, almost everyone here would have done exactly the same thing!

You are Daisy’s champion and she wants you happy and would be very upset if she thought you were east I g your energy on this!! And you wouldn’t want to make sweet Daisy upset:-) :-)

Okay, you have to do something right. now for Daisy:-) Hug yourself……come on… big old wrap around hug…and tell yourself “good job cutie pie”:-) :-) Now go hug Daisy and tell her “good job cutie pie”:-) :-) :-)

You and Daisy are doing a wonderful job:-) :-)

Take care of yourself, Alicia!! Daisy says so! Sally and Happy Hannah

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

The Rainbow Bridge



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1 May 2013 - 9:57 pm
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Alicia, you can make yourself crazy with all the “what ifs.” Cancer will do what it wants to no matter how proactive we are or how much money we spend trying to fight it. Don’t let it “win” by beating yourself up. You are a great pawrent who is doing all you can for Daisy and that’s all that matters.

I’m glad she ate dinner tonight! Come back to the chat, I’m sorry we didn’t get to talk too long tonight.

It's better to hop on three legs than to limp on four.™
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