Tripawds Three Legged Dog & Cat Forum Archives

…news, so a lot of what the doctor said to me went in one ear and out the other, but the outcome is that we have begun a home treatment regimen of Palladia (65 mg 3X a week) and Losartin (200 mg 2X a day).  She is tolerating the meds well so far after 2 doses of this oral chemo treatment.  She has

…tumor has metastasized (they think based on the 2 lymph nodes they removed) so they're suggesting intravenous chemo for 12 weeks or re-start the Palladia or just do nothing and let him live his life.  None of these are easy decisions based on what he's already been through so we're holding off until

…can be done if symptoms do start showing up. You can ask your vet about prednisone, or IF coughing shows up cough meds, also maybe  metronomics
, Palladia, etc.

FWIW, Generally, not always, but generally the Mets are not painful per se. Extreme exhaustion, lack of energy shows up more often than not

…thought somewhat effective for lung mats and various forms of cancer.   Not sure if that's still the case but it's worth asking about

As far as palladia, I know some have tried it and have seen no success and some feel like they have seen some success. Like everything on this during journey, so many

…where he could be in the woods again and go on nature walks, maybe even run in a field again. 

Our doctor gave us the option of trying oral chemo, Palladia, at home, and we are going to give it a shot. The goal is to try to slow the cancer down just a little longer so we can give him a few more

… Banksy is doing wonderfully. High energy, eating well, sweet as can be. She quit responding to chlorambucil so the oncologist switched her to palladia. Today we found out it's still not stopping the growth in her lungs. There's two small nodules they're worried about.

They recommended today…

…that we start her on doxorubicin. Other options were carboplatin or to up her palladia dosage and add back in chlorambucil. When asking the doctor which she recommended, she said all of them were 50/50 which was no help at all. I know

…attempts.  

What we did do is put her on a combination therapy of sorafenib, Losartan and propranolol.  Sorafenib is a drug in the same class as Palladia but with a wider net of effectiveness.  It just hasn’t been studied on canine osteosarcoma.  She has been on this therapy along with the

…and growing quickly. What Grade is it? Can you post the report? Chemo is the ideal way to treat mast cell tumors but you could also consider Palladia or even just prednisone with Benadryl and an antacid or holistic treatments. They can also run a prognostic mast cell panel that gives you a better

…vet. Have they seen her since this started? If so what did they recommend?

I'm not sure if you saw Dr. Pam's feeback? I also answered your Palladia question, which I know doesn't relate to this one directly but want to make sure you're seeing the suggestions.

Unfortunately, solving these kinds

…. She is a 12-year-old osteosarcoma survivor with her front right leg amputated. The cancer has spread to her lungs as of last week. She is on palladia right now. This is a pretty urgent cry for help: for the last month or so she has been struggling to walk, sit, and get up. Her back legs often

…Jennifer,

I'm so sorry about your pup. Getting the mets news is such a gut punch, I remember it well.

Many people here have used Palladia with the hopes to control tumors. Honestly, we haven't seen a ton of long-term success with it over the years, but that's not to say it won't work…

…it's the same cancer type. 

Did your oncologist mention any other options? We have seen some advances in lung metastasis therapies come out since Palladia was released several years ago. Some are still in clinical trial phase and some are new to the market. Here are some links to check out:

https:

…old tripod has two small tumors in her lungs. This is the first sign of cancer since her amputation nine months ago. Her oncologist is recommending Palladia for a few months to help stabilize the tumor and prevent any growth. Does anyone have experience with this drug? What was your dog's experience?

…at the University of Florida who are doing this procedure now.

7. Has anyone had any success with the drug combo of losartan, propranolol, and palladia? has anyone done that prior to amputation, radiation or chemo?

Do you have links to studies done with this combo that you can share? It sounds

…as there is just so little exposure of this in the US market. 

7. Has anyone had any success with the drug combo of losartan, propranolol, and palladia? has anyone done that prior to amputation, radiation or chemo?

8. We switched her to a keto diet consisting of turkey, broccoli, green beans,

…chemo uses a low dose of an oral chemotherapy agent daily or they might try something like Palladia. I would discuss this with your oncologist to see if this may be an option for your dog.

Pam

…age-related conditions, not the tumor itself. So yes, it's mostly a palliative treatment.

One of the oncologists said that chemotherapy with Palladia and Leukeran could be tried. Do you have any experience of this?

With usually see those used for as a last-ditch-effort treating lung

…chemotherapy
(with thalidomide and cyclophosphamide). Unfortunately, that didn't help.

One of the oncologists said that chemotherapy with Palladia and Leukeran could be tried. Do you have any experience of this?

As far as electrochemotherapy
is concerned, the same oncologist said at the

… they just move from one moment to the other, and deal with whatever challenges they may have. I'm sure you know, but to spend time second-guessing palladia, the treatment protocol, Etc keeps you away from the wonderful thousands of happy memories you have with Tucker. And for whatever it's worth,…

… although I'm sure there are exceptions, Palladia often seems to cause a lot of side effects and not particularly good results sometimes. I think in Tucker's condition at that point it would have

…first re-check appointment, 4 weeks after the re-infusion, we learned that the cancer had already metastasized to his lungs. We discussed starting Palladia, but Elias ended up advising our vet to hold off and x-ray again in another month. They thought it was possible (from previous cases) that the…

…radiographs might be highlighting inflammation from the Elias treatment attacking the cancer. I also asked if Palladia would potentially interfere with the immunotherapy, in case it was still working to fight the cancer and was told that it would not. I asked why we…

…wouldn’t just start the Palladia to get everything going to fight this, but our oncologist (I should add, this was not Dr. Wall – we’d begun working with a closer oncologist for…

…off. She said we wouldn’t know which was working if we started both and his next x-rays showed improvement. Also, she liked the idea of keeping Palladia in our “back pocket”. I am still a little angry with myself for not pushing to start Palladia. As I discussed with my husband after that call, I

…good to see Ophelia is doing well ! Delighted to see the spryng  & stopping the Palladia helped👏🏻👏🏻👏🏻 whoo hoo

Hoppy New Year

Hugs

…6 months since amputation. 

She seems to have regained some of the mobility that she lost in October and November.  No one knows the cause.  The Palladia?  Arthritis?  Her fall down the stair?  Combination of all of it?  But between taking her off of the Palladia and the Spryng injection, she seems

…palliative care.

Mag's little sis Tani also had mast cell cancer but most of her tumors were on her torso.  The vets wanted to do a drug called palladia which was fairly new back then.  Because Tani had multiple health issues I again declined treatment.  Tani lived many years with multiple mast cell

…wnd hopefully  that will be the case for Atlas. 

IF, IF, IF there are mets, he is symptom free and very early on.  There are other options and Palladia  is one of them, Metronomics  another.  

As far as posting  poctures pf Atlas, here's a link.  In the meantime,  I would be honored  to post them

…else going on. I was really interested in the Yale vaccine, but it is too far away from me. It looks like my options right now are chemo and maybe Palladia. It would be wonderful if the Yale vaccine was USDA approved soon and commercially available. I wonder when their trial will be complete?

Thanks

… the links are in my signature below.  Just be aware that her amp and chemo were in 2006/2007- there have been new treatments developed since then, palladia is and example.

I spent those first 6 to 9 months watching the calendar, and honestly waiting for her to pass.  Meanwhile she was hopping along

…. Following that, they will do the chest/ab scans and liver/spleen aspirates to check for evidence of spread. We will then continue will oral chemo, Palladia. 

While the surgeon was hopeful and said the grade 3 tumor found in the removed lymph node was not a death sentence - that if he is clear in 6

…also wanted to add my reasoning for telling the vets about stopping Palladia. Our vets need to know what we are doing to do their job helping Ophelia and for any labs that will be needed in the future. I would hate to see…

…decisions together as you have been doing and what's best for Ophelia. It may mean pushing back, too. You have a sense and a nagging about the Palladia; thats your gut instinct. LISTEN to that.

They would appreciate an honest discussion, making their job easier. They KNOW you want the best for…

…Ophelia. You are NOT done fighting C a by stopping the Palladia. You are fighting C daily and have gone after it with all you have. As you said, this is preventative, and it's not like this drug is 100%; the…

…measures you have done have a better shot at kicking its arse Super Stu lived four years and ten months with amputation and chemo; he did not do palladia or immunotherapy, for example. No one has the crystal balls here. What timeline any of us get is a crapshoot. That's the biggest lesson we all

…everyone.  Holly really expressed what would be "my thoughts" too.

I think I mentioned earlier that msny dogs have to get off of Palladia because of side effects. I don't recall specifically what they were but your observation and research about the lameness is quite interesting. Keep…

…in. mind that certainly  are no guarantees with Palladia anyway.   You are doing a good job of figuring out how to connect the dots back to Palladia if that is a cause and effect of the lameness.

Anyway, glad that there seems to be some improvement  since she had the injection.  Of course,

…We can throw everything at C and still lose this battle; we don't want to lose QOL.

I would talk to the vet and let them know you have stopped the Palladia and the WHY and get their input, knowing you have the final say, regardless of the feedback you do get. I would keep them in the loop. If you have

….  

But i began to do a little research a couple of nights ago and found that something called “shifting lameness” CAN BE a side effect of the drug Palladia.  “Shifting lameness” is described as being similar to growing pains in a puppy.  Lethargy can also be a side effect, which is had already known. …

… 

After reading this, i decided to go back and do a timeline of when we began with the Palladia and when she fell, and when i noticed a difference in her stamina and pain level.  Besides one fall that I’m pretty sure predated the Palladia,…

… everything else occurred after about 2-3 doses of the Palladia, and got worse after about three weeks on the drug.  

I have not yet mentioned this to either the pain management
doc or her oncologist but I’ve…

…made the decision to stop the Palladia for the time being to see if she reverts back to her stamina and mobility levels prior to mid-October. If she does, the question will then be if…

…that is a result of the Spryng treatment or removing the Palladia.  I will cross that bridge if we get to it but I’d probably add the Palladia back in to see if she then goes back to having pain symptoms.  

The downside to this of course is that i feel like I’m not treating for the strong…

…possibility of metastasis of her cancer.  However, her quality of life has to be the priority.  The Palladia was being used to try and beat back something that may not occur due to the other treatments that she’s already received, ie, the ELIAS immunotherapy