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Shiloh update - nodes in lung
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Member Since:
14 December 2022
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13 March 2023 - 6:22 pm
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Shiloh had a front leg amputated for osteosarcoma in mid-December. He is a 10 year old collie mix. He has had 3 chemo treatments with carboplatin 3 weeks apart. He did very well with no side effects - good appetite.

Today he was due for his fourth treatment and they wanted to repeat lung X-rays and abdominal ultrasound as well as bloodwork. All was good except the lung X-ray showed some very small nodes. Still that meant metastasis. The vet recommended switching chemo drugs to Adriamycin. There was a choice for me of injectable every 2-3 weeks or daily oral form. She said the injectable had more punch but could be more problematic for side effects. He has done so well so far, I decided to try the injectable and we could switch later if needed. So he had his first treatment today. We'll see how it goes. They will recheck after another 3 treatments.

It was a setback to me that the cancer is showing up already. I know it usually recurs but I was hoping this would be months down the line. I will let you all know how it goes. I welcome any advice as always. You guys have been great - I am so grateful for this group.

Virginia







Member Since:
22 February 2013
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13 March 2023 - 8:59 pm
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Cert this isn't  what you wanted to hear.  The important thi g is Shiloh  did hear sword about mets AND he is still being Shiloh.  Pl,ease know that many dogs here have gotten a lot of quality extended  pain free time in spite of mets.  Rene will tell you that JERRY is a splendid examp of jow to live life to the fullest in spite of mets.  

Hopping on  quickly. to post something I just read here  that another dog is taking when a met was found.    

 

  My dog Akira - after having had a rear leg removed in October due to bone cancer, is now into her 7th week of a combo Palladia and Losartan (after an initial 10 weeks with Carboplatin that wasn't producing any effect), and a couple weeks back x-rays confirmed a 35% reduction in the size of a small tumor that was growing in her lung.  So 'good'!

   

   Hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

The Rainbow Bridge



Member Since:
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14 March 2023 - 11:38 am
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Dangit I'm sorry about the lung mets. Gah! I hate those things.

Treating it sounds like a reasonable plan. I'm not familiar with adriamycin for lung mets, and will be interested in following along. My fingers are crossed that it works and Shiloh does well with it. Take THAT cancer! POW! 

You might want to ask your oncologist about the MIMIC study for lung metastasis. Shiloh might be a good candidate. Although the surgery is done in San Diego, CA, follow ups can be done at any Ethos clinic around the country or at your own I believe. If it's not an option don't beat yourself up. You are doing everything possible to give Shiloh a fighting chance while keeping his quality of life as the #1 goal and that's what counts most.

Speaking of your amazing boy, give him a hug and lots of belly scratches from us! Keep us posted.

Colorado
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24 May 2023 - 4:40 pm
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Hi Janet, I was curious if there are any updates on dear Shiloh? My Ellie showed up with lung nodules before her 3rd carboplatin treatment, so very similar.

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29 May 2023 - 7:44 pm
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Thanks for asking. It's been a long haul. After we switched to the other chemo drug, we retested after 3 weeks and it wasn't good. The nodes he had before were bigger and there were new ones showing up.

So the oncologist said we should try Palladia and Losartan. I read on one of the forums that someone saw shrinkage of nodes with these pills. The vet said she had seen improvement in patients also but didn't have a lot of cases so far. So Palladia is the chemo drug. I give that Monday, Wednesday and Friday. The Losartan he gets twice a day every day. We are in our fifth week and he will have a scan this coming Friday.

Things went well at first but he has gotten much more lethargic and weaker. In the past few days, he has struggled while walking so I am very worried. This is a possible side effect of Palladia but could it be the cancer? This is Memorial Day so I didn't call the vet but I sent an email to the oncologist so I will see what she says hopefully tomorrow. I started giving him pain medication but it is hard to tell if he is in pain or just weak. He still has a good appetite, God bless him. He loves to eat.

I'll let everyone know how it turns out. Good luck to everyone struggling with this horrible cancer.

Virginia







Member Since:
22 February 2013
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29 May 2023 - 9:09 pm
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So kind of you to share the update on Shiloh.  Your feedback helps others going through  similar situations  and looking for options.

As far as I can recall, leg weakness can be a side effect of Palladia.  Cant recall of it goes away once Palladia is stopped or dose reduced. Try not to go to worse case sce6 as it may just be a side effect aqnd that can be addressed.

The fact that Shiloh has a good appetite  is good news! A good sign. Continue to chow down sweet boy!

We're  all cheering for Shiloh!

Hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

The Rainbow Bridge



Member Since:
25 April 2007
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29 May 2023 - 10:50 pm
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Aww I'm sorry he's feeling so icky. That kind of side effect from Palladia is something we've definitely seen around here in a few dogs. Your vet should be able to guide you with a way to help him feel better and tailor the dosage.

Let us know what they say when you get a chance.

Colorado
Member Since:
15 March 2023
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30 May 2023 - 9:13 am
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Janet, thank you for the update, I'm sorry he's not feeling 100%, hopefully it's doing it's job in shrinking those suckers (literal life suckers).

I want to say thank you for being willing to share the not so upbeat side of this awful disease, we all hope for the fairy book ending where our dog beats all the odds, but odds are odds for a reason and most of us have to make really hard decisions on what is best for our pups.

I have not decided what my next steps are with Ellie, but we are in the same boat as you guys, she shows small lung nodules.  She was in a clinical trial and is now no longer eligible since there was progression so she is currently not on any treatment at the moment.  They are also recommending Palladia/Losartan, but I just don't know. I'm trying to gather as much information as I can before moving forward so hearing how Shiloh is doing really helps.

I hope you get some answers for his weakness today and my fingers are crossed for Friday!

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12 June 2023 - 7:57 pm
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Well, not good news on Shiloh, but I felt I should let people know our story. 

Shiloh continued to get weaker on the Palladia and Losartan so much that I had to start helping him to get up and walking was wobbly. The oncologist suggested stopping the Palladia and then I stopped the Losartan also because both of those meds can have that side effect. So after about 5 days his walking was better. He went to the vet for a check of his blood. I also had them check a lump I had just found on his side.

So the lump was aspirated and sent to the pathologist. The report said this was a sarcoma but a different kind from the osteosarcoma, go figure. The oncologist says this does indicate that the Palladia/Losartan was not working the way we had hoped. I asked her why they didn't check his lungs to see if the nodes had shrunk, and she said with the oral medications they usually do the X-rays at 2 months and we were at 6 weeks. 

But I had stopped the meds so she said we could restart the Palladia/Losartan or get the X-ray now. I opted for the latter, but the appointment was for about 4 days from then. I should say that Shiloh had been occasionally having some kind of gagging in the rmorning. This suddenly got much worse and he started having these bouts of retching and gagging (that's what it looked like to me, but was it respiratory or digestive?) After a terrible night of this the oncologist had me try three kinds of nausea medicine together but there was no effect. His walking was getting bad again and we talked about possible problems in his one front leg.

I think I should have run him in on emergency but I didn't. So the day came to go for the X-ray but at this point his breathing was bad. I asked the oncologist on the phone if there was a path forward and she said she needed the tests but there might be a possibility of antibiotics. 

So after some soul searching I decided he had had enough. I am pretty sure the cancer is causing all the symptoms, even without the X-rays and to start the chemo again might mean his walking that is bad now would be even worse. It was a hard decision because I love him so much but I can't be selfish and have to think of his quality of life.

He has been a trooper through all of this. We have had almost 6 months from the surgery that he most likely would not have had. Most of that time he had good quality of life. He never had side effects from the chemo until just recently with the weakness. He ate good throughout and was playful.

Thanks for this very wonderful website and I wish everyone to have as long as they can of a good life with their fur babies.

The Rainbow Bridge



Member Since:
25 April 2007
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13 June 2023 - 9:26 am
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Oh Janet, I'm so sorry you and Shiloh have been going through these struggles, what a tough time! Just know that you are doing everything possible to ensure his quality of life stays #1, and for that he will be forever grateful. Putting your own heartache aside for the sake of his comfort is the highest calling a pet parent receives from the universe. It's so hard, but making that decision to stop medical intervention is a selfless gift you gave him. My heart goes out to you, and remember if you want support, we are here for you now and always. Even though he was only part of our community for a short period of time, his legacy lives on here forever. 

Lots and lots of love and hugs coming your way. sp_hearticon2sp_hearticon2sp_hearticon2

Colorado
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15 March 2023
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14 June 2023 - 12:05 pm
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Janet, thank you for sharing, I know it was really painful to but I really really appreciate it.  I'm so sorry- but you have an amazing attitude about it.  You're doing what's best for Shiloh and that's all any of us can do.  It's a true act of love to be able to let go and put his quality of life first.

I promise to follow your lead and continue to share Ellie's story regardless of what happens because I agree that the pet parents that come after us deserve to have as much information as possible to make the best decision for their babes.

You and Shiloh will continue to be in my thoughts.

Virginia







Member Since:
22 February 2013
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15 June 2023 - 10:12 am
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Just know that it is so clear to all pf us that you will always do what is in the  best interest of Shiloh.  Always.  And he knows that too,♥️

The bond that you have with him is unbreakable and eternal and nothing can ever interfere with that depth of love.

Shiloh's story will continue to inspire on so many levels.  We can all learn from the courage you have shown to know when to "try" medical intervention  and to know when ro stop.  Stopping is not "giving up". It's knowing your Shiloh well enough to know he can no longer be Shiloh.

Know that we are here for you in any way you need us.

Surrounding  you with peace and clarity and Shiloh's eternal love💖

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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