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Oral Chemo Palladia and Chlorambucil
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Member Since:
31 August 2020
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20 January 2021 - 8:47 pm
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jerry said
Drats, I'm just so sorry the Palladia is giving him such a hard time. Poor guy, I know you must be so worried. Tomorrow you should have some answers for your just-say-no-to-drugs kiddo. And never apologize for any thing like sharing a grody side effect, it's reality and it's good to share so that anyone else going through it with their pup doesn't fee alone. 

Regarding the Palladia, see if your onco vet thinks that Odansetron could work. It's pretty powerful for settling a nauseated belly.

Keep us posted, know that your happy crazy boy is still there, and remember we are sending you guys the full force of Tripawds Pawsitivity! 

  

I asked about Odansetron and she (onco) said yes, it could help, and she will order it for us tomorrow in case he is still refusing food and nauseous. Thank you for mentioning that!!

On The Road


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21 January 2021 - 11:07 am
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I read lots of glimmers of pawsitivity in your update, thank you for sharing. We have our paws crossed he had a good night. How is he doing?

Oh I hope the Odansetron works! Let us know OK? 

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

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21 January 2021 - 6:51 pm
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We made it through a very rough patch. Poor Zeus was so nauseous from 5am until about after lunch time. He was licking everything in sight, burping, trying to throw up but since his stomach was empty there was nothing to bring up. He would not take anything we offered, and the little that he did he would spit it right out - but he did drink water and kept it in which was a good sign. I guess Palladia really wrecked his system. He finally settled around 2pm. I gave him a bit of time then slowly introduced boiled chicken and then a bit more and he ended up eating two chicken breasts and some pumpkin and fell asleep so peacefully. I felt so happy, and relieved, for him to finally get some rest. And then I passed out right next to him!

If we had any indication that Palladia would cause him this much discomfort we would have never opted for it. I though the worst thing would be diarrhea. But hindsight is always 20/20.

I was in touch with his oncologist throughout the day, she wants to wait at least a few more days before we make any further decisions. She said that Chlorambucil 4mg taken daily is unlikely to cause any side effects, but as expected, I am now terrified of another reaction. We are taking it day by day for now and I have no idea how we are going to proceed. First priority is to have him eating again and settle his entire body.

From everything I read about possible side-effect of Palladia Zeus is truly an exception to have such a strong reaction from breathing issues to severe nausea. I do still think that Palladia does wonders in reducing the size of the lung nodules and is even promising in completely shrinking them to nothingness. Who knows what else played a part in Zeus getting so sick from it. We will never know for sure but we are moving on.

On The Road


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21 January 2021 - 7:54 pm
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Oh poor Zeus and poor you! I'm so sorry this awful situation happened. It's nice to be exceptional sometimes but not in these situations, that's for sure.

I'm sending all the love in the world to you for better days ahead. I hope his belly stays settled and you all get more rest. Take things one day at a time and you will find the best path for you guys to take. Keep us posted OK?

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Virginia







Member Since:
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21 January 2021 - 8:40 pm
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I'm so glad Zeus is finally starting to feel better and is gaink g his appetite  back.  Getting him back to this point had to be gutwrenching for you to watch the past several days and nights.

I can't recall specific inxtances right now, but there have been members who had to stop Palladia because the side effects were too severe to warrant possible benefits.  Actually, I think one such member was dog Eocky, hooman David.  I'll have to research.  And of course, Stacy didn't  have a great experience  with Palladia for Griffin.

Of course, there are no guarantees one way or another as far as whether Palladia is effective on all dogs.  And if effective, for how long, etc.

You made a decision  to try Palladia amd that is what many, many in your situation would try.  And that decision  was made with the hope it would help and also give you the confidence  you are trying everything  possible to give your Zeus quaility  extended  time.  It appears Zeus has had a fairly  severe reaction and that is where you have to decide where your "lline in the sand" is.

So all drugs out of his system st this point, including.Chlorambucil, right?

I'm just so glad he's feeling better and yoj both got some rest.  We're  all cheer for sweet boy  Zeus!!!   Sich a loved boy❤

Hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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23 January 2021 - 6:25 pm
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Yes, all drugs are out of his system now. We had two really, really good days since my last post. He is back to his old self, he is alert and energetic, playful and hungry!! We took him hiking today even though it was really cold - he prefers winters over summer heat anyways so he had an absolute blast in the snow. He was running, chasing after sticks, getting love from random people on the trail, just a regular day. He is eating like a champ now but he did lose about 5lb during this event. We will get his weight up though, now that he is back to eating. We have a follow up with his Oncologist on Monday and will decide then how to move forward.

We are just so happy he is back to his normal self!

Virginia







Member Since:
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23 January 2021 - 7:26 pm
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Sooooo happy to read this update!!!   No better feeling than having your boy back😁😁

5 lbs down.....Zeus will have such a great time chunking backup with treats!!-   YAY ZEUS!

Hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

On The Road


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24 January 2021 - 1:45 pm
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YIPEEE!!! Oh my dog I'm so hoppy to hear Zeus is back in a big way! YAY! Got any photos to share? We would love to see them!

Cheers to more good times ahead, Team Zeus is amazing!

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

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26 January 2021 - 2:35 pm
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After many, many conversations with Zeus's oncologist we have decided to continue with Chlorambucil. She assures us, as much as that is possible, that the medication is very well tolerated. I do want him in my life as long as possible however not at all cost. At the first sign that he is having a reaction I am going to stop it and let him just be happy.

So... I have some technical questions regarding the proper handling of medication and related human exposure without limiting the necessary affection and protecting our cat as well. There are many things to consider and even though we have the instructions from the clinic they seem to be vague and general. Are there any big 'no-no' to worry about? I've read that the bottle should not be sitting next to human food - ours has been in the fridge since January 4th in close proximity to our food.

Also, we often play with puzzle toys and Zeus starts to drool at a first glance of a treat and it always ends up as a messy game but so much fun - do I need to worry about it now?

I figured I would come here to get the best suggestions on how to handle things - I know a lot of it is common sense but you are dealing with a human that will use peppermint oil for headaches and advil only as a desperate measure and a very last resort. smiley9

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New York, NY
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26 January 2021 - 4:51 pm
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Hi!  I thought I'd chime in about chlorambucil now that Griffin's been taking it for almost 3 weeks.  Overall, he has tolerated it very well.  When the discussion was raised about administering it on an empty stomach versus with food, I started giving Griffin the drug at night before bed, which resulted in vomiting episodes, so I now administer his meds mid-afternoon, at least 3 hours after his breakfast and at least 1 hour prior to his supper.  Griffin has not shown any negative side effects with the new administration plan, nor did he have any issues when it was given with food.  I am keeping my fingers crossed that Zeus also tolerates the drug well!

The compounding pharmacy that dispensed Griffin's prescription provided general directions that I received with all other chemo drugs about using gloves (which the pharmacy provided) and being careful with urine/feces.  I have not seen any specific information about saliva.  Here is a general safe handling chemo for pet owners document that I found online (although I know Tripawds folks likely have more specific guidance): https://cvm.ncs.....c-copy.pdf

Griffin lived an amazing life for 11 years! Diagnosed with osteosarcoma on March 17, 2020, Griffin's right forelimb was amputated on April 2, 2020. Ten days later he was running and playing fetch! Lung metastasis discovered in July 2020 did not slow down Griffin and he lived joyfully for the next 7 months, passing peacefully at home on February 11, 2021. https://griffin.tripawds.com

On The Road


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26 January 2021 - 7:02 pm
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Sounds like a reasonable way to go. Our Jerry was on oral chemo and other than wearing gloves and being careful around urine and poop, there wasn't much to worry about. I believe it goes through their system in I want to say 12 hours and that's that, but don't quote me. How often will he be taking it? 

There is a small chance of urinary cystitis but statistically male dogs have less of a chance of developing it, so paws crossed it is kind to sweet Zeus!

I'm bummed the photos didn't show up. Where did you try pasting them from?

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

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26 January 2021 - 9:33 pm
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I think I will continue to give him the pills with food, or close to meals, for now at least and adjust if necessary. He will be taking them daily so he will have a continuous supply of toxicity that we need to manage.

Stacy - thank you for the link. Coincidentally, I was looking at that pdf earlier today. 😉

When I posted the photos I copy/pasted from my folder and I could see them on the post fine but once I clicked on "submit reply" they were no longer displayed. I will try something else!!

On The Road


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26 January 2021 - 9:37 pm
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From your folder on your computer? If so, you'll need to upload onto a Tripawds blog or a photo sharing site like Imgur.com and such. This is how adding images  to the Forums works.

1. Upload pics to a photo sharing site like imgur.com or your own Tripawds blog!
2. Right click and copy the Image URL or just copy the image if you’re on a phone
3. Return to your Tripawds Forum post and paste the image URL (or the image itself) in your post. It should automatically appear.

If you’d like help figuring out the process let me know. We can't wait to see them!

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

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1 February 2021 - 9:51 pm
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Just a quick update on our Zeus. So far no reactions to Chlorambucil (Phew). We hope it stays that way. He is completely back to his old self, full of energy, has a really healthy appetite and his weight is back up. He had a check up today and blood work is all normal. We are going back for x-rays in a few weeks but until then we are enjoying every single moment!!

Ears up!

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Zeus on his backseat throne.

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Everything has to be covered except for the tip of his nose.

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New York, NY
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2 February 2021 - 9:30 am
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What a fantastic update!  Zeus looks so happy romping in the snow.  I'm so glad he is doing well with chlorambucil and has all of his sparkle back.  Yay, Zeus!

Griffin lived an amazing life for 11 years! Diagnosed with osteosarcoma on March 17, 2020, Griffin's right forelimb was amputated on April 2, 2020. Ten days later he was running and playing fetch! Lung metastasis discovered in July 2020 did not slow down Griffin and he lived joyfully for the next 7 months, passing peacefully at home on February 11, 2021. https://griffin.tripawds.com

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