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Caring for a Three Legged Dog or Cat

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Nitrosylcobalamin
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Maddog
1
11 July 2009 - 5:34 pm
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Does anyone know anything else about Nitrosylcobalamin?, I found a website from DFHCC (Dana Farber/Harvard Cancer Center) This is a compound that acts like a Trojan Horse to target the cancer cells without them expecting it, It also doesn't cause toxicity in the body and doesn't harm the surrounding tissue, The treatment was used in dogs, and they saw an almost 80% reduction in tumors, Out of the three original dogs, one of them is also completely free of cancer and has been that way on and off of treatment for 2 years, if it continues to do well, the researchers will put it to the FDA for human trial, Whether or not it will work in humans is something that remains to be seen, But, it does work in dogs and is one of the most promising new treatments. I took this out of the DFHCC website, There website is http://WWW.DFHCC.ORG. I'm hoping this would work for my 8 yrs. old Rottweiler with osteosarcoma.

Kirkland, WA
Member Since:
2 June 2009
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2
11 July 2009 - 6:10 pm
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Oh my gosh!  That sounds so promising!  Thank you for bringing this to our attention.  My dog also has osteosarcoma and I will be sure to ask our oncologist about this at our second chemo session this week.  Thanks for the tip!

On The Road


Member Since:
24 September 2009
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3
11 July 2009 - 6:10 pm
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Thank you so much for starting this conversation Maddog, we can't wait to hear what others have to say about it.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Kirkland, WA
Member Since:
2 June 2009
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4
12 July 2009 - 3:19 pm
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So, I did some research on this and found a website that is devoted to clinical trials of the drug (the Bauer Research Foundation in Akron, OH).  I sent off a quick message and received this response :

"Hi Laura- I received your message- We have received many inquiries from owners with dogs and cats that have cancer.
 
As of July 9th 2009- the Washington, DC office of the United States Food and Drug Administration (FDA) sent an FDA investigator to investigate myself, my family and the Bauer Research Foundation to make sure we were not making NO-Cbl, shipping NO-Cbl or treating dogs with NO-Cbl. All dog studies that used NO-Cbl were conducted at the Cleveland Clinic under the direction of Cleveland Clinic personnel. 
 
I urge you to contact your Congressman to ask: why there has been no benefit, in terms of the response rates, with anti-cancer drug development in the past 40 years?! If the status quo of anti-cancer drug development is not working- why haven't changes been implemented? Clearly, the FDA has the time, energy and man-power to investigate me and my family- why not focus that energy on making a difference! Why are all anti-cancer drugs viewed the same by the FDA in terms of approval (i.e. NO-Cbl is a targeted anti-cancer agent made from vitamin B12, but still the FDA requires pre-clinical testing costing $400K + with no distinction from typical cytotoxic chemotherapeutic agents? Why are you not permitted,  as a pet owner, with the consent and supervision of your veterinarian to treat your pet with any drug that may be beneficial? The only way these out-dated policies will ever change is to raise awareness on a national level.
 
We currently do not have any drug available. The Bauer Research Foundation (BRF) is working with local veterinarians as well as veterinary offices across the USA to possibly begin a study (Fall 2010) to treat dogs and cats with a vitamin B12-based chemotherapy agent, nitrosylcobalamin (a non-toxic drug,  patented in 1999). The ability to conduct such a study will depend on acceptance of a New Animal Drug Application (NADA) by the United States Food and Drug Administration (FDA) as well as other FDA-mandated  requirements (these will cost in excess of $400,000). We are working on finalizing a contract with a small pharmaceutical company to make NO-Cbl for us. We are also trying to raise funds to provide the drug free-of-charge to as many animals as possible. I will notify you when the drug becomes available and can be used to treat animals as approved by the FDA. Your veterinarian will be required to write a prescription to obtain NO-Cbl.
 
I recommend contacting your local holistic veterinarian for advice, dietary recommendations or alternative therapies. Dr. Judith Shoemaker is nationally recognized as a holistic veterinary licensed in 17 states. You may visit her website at http://www.judi.....maker.com/

http://docs.goo.....tion%2Fpdf

On The Road


Member Since:
24 September 2009
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5
12 July 2009 - 6:49 pm
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Thanks for doing the research! Those PDF links appear to be GoogleDocs which require account login. Feel free to send us the files if you have them and we can post them here.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Allie
7
3 September 2009 - 7:52 am
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I also contacted Dr. Bauer after reading an article about him. I was interested in using NO-Cbl for my dog, Maddie who has grade II mast cell cancer that we think has spread to a lymph node.

I got a similar reply to the one posted above. I also asked Dr. Bauer how long he estimated it might be before NO-Cbl could be available to the public by a vet's prescription and he said three years, because of the difficulty of raising the $400,000 needed to get the product through the toxicity tests required by the FDA.

I plan to contact my Congressman. I would also like to help spread the word in some way. It's so sad that there's this promising treatment available and yet we cannot get it because of bureaucratic red tape. It's funny to me that this non-toxic product has to pass through toxicity tests while products so toxic you must wear Latex gloves when giving them to your dog are the "standard" of treatment when you go into a veterinary oncologist. I would really like to help do something about this, but I'm not sure what to do.

Leland Courtois
8
3 February 2019 - 12:06 pm
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Is nitrosylcobalamin available yet? I have a beagle with cancer.

On The Road


Member Since:
24 September 2009
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9
3 February 2019 - 3:13 pm
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Leland, thanks for asking a good question. It appears to me that the nitrosylcobalamin therapy is not widely available and hasn't gained any momentum for many years. 

My best guess is because it hasn't lived up to expectations, but the best person to ask is your integrative oncologist. If you find out any new information please do share here. Thanks so much and we hope your Beagle kicks cancer's butt.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Shelby J
10
22 June 2022 - 9:04 pm
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Any updates on availability yet? Trying to find alternative treatments for my boxer asap.

The Rainbow Bridge


Member Since:
25 April 2007
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11
23 June 2022 - 9:29 am
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I searched the Google and couldn't find anything published about it for at least a decade. Honestly there are better, more studied therapies out there that a good integrative vet can point you to.

If you haven't already found one, be sure to search the https://www.ahv.....erinarian/ directory for a practitioner. Best wishes for much success!

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