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Lung mets growth - switching from carboplatin to doxorubicin side effects
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Member Since:
16 April 2022
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9 June 2022 - 7:51 am
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Unfortunately for us, after two rounds or carboplatin, the lung mets continued to grow and spread. We switched to doxorubicin but the side effects are terrible. Kite did not have any problems with carboplatin, but on doxorubicin, he was off his food for many days and the diarrhea... 🙁 we are on day 5 of diarrhea and nothing seems to be helping. We tried metronidazole, probiotics (Forti Flora), psyllium (plain Metamucil), putting him on Purina EN. We will keep trying the psyllium and EN and perhaps increasing the dose for psyllium but just wondering how long did people experience the diarrhea for in your dogs?

This is making us hesitate a lot on giving him another dose of doxorubicin. icon_cry

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25 April 2007
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9 June 2022 - 10:53 am
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Oh poor Kite! I'm so sorry. 

Sounds like you are working with your vet on the runny poo. Check out our story about diarrhea, and get RX Vitamins Edible Green Clay asap. In a pinch you can go to a Whole Foods or natural foods store like that and get bentonite clay, same thing pretty much. It's benign as far as any kind of supplement, absorbs the toxins and soothes the belly. Many vets use it (ask yours if it would be OK to try of course), and there's lots of success stories around here. We're such fans that we include it in the Kaiserin Pet Cancer Care Package.

Yeah doxorubicin can be harsh! We learned about it years ago with Dr. Chretin. I'm so sorry Kite is feeling so badly! Hope things perk up soon. Oh and as far as timeline goes, it's pretty different for everyone as far as I recall. No direct experience here, I'm so sorry. Hopefully others can chime in. 

Here are some forums posts about doxorubicin side effects. Oh and more discussing doxorubicin and diarrhea.


Member Since:
22 February 2013
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9 June 2022 - 11:18 am
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Bummer Kite is having such a rough time.  I know it's sich a fine line when it comes to the ""possible" benefits of a ,drug, verses the side effects  interfering  with quality.    Reviewing  previous posts, Kite had to  be sedated for the Carbo, , assuming same for Doxor..???  He also didn't  like the Vet visits??

Perhaps you could get a consult  with a Holistic Vet for other options?   Perhaps  they  could  siggest a treatment that could be beneficial  but without harsh side effects.  

Aside from the rough times Kite is experiencing right now, prior to this was his attitude good, lots ,of tail wags, enjoying being Kite?

Keep is posted and hopefully  some of suggestions Jerry offered will help.  Make sure he's drinking  plenty of fluids.

Extra hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

Member Since:
16 April 2022
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9 June 2022 - 2:10 pm
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Kite actually didn’t need to be sedated for his second round of carbo. But for doxorubicin, the vet prefers to sedate dogs anyway because the drug is dangerous when leaked out and takes a lot longer to administer. Kite does not like vet visits for sure but has gotten ok with going for his chemo. 
other than the diarrhea and feeling like he needs to go #2 more often than he really does honestly Kite is doing well, all things considered. He still wants to go for rides and walks/hops etc. 

I guess that is our biggest dilemma - do we try everything and risk the diarrhea in hopes that he can have more time or just simply let him enjoy whatever time he has left. 

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