Ohhh poor Loki! You have our whole pack just feeling so bad for him! And you, that's tough to go through.

You are doing everything right as far as massage and cold therapy, but do get on the phone with your vet asap to talk about this. In this pain management article, Dr. Petty (immediate-past president of the International Veterinary Academy of Pain Management (IVAPM) and co-author of the 2014 American Animal Hospital Association Pain Guidelines) recommends:

Dog and Cat Amputation Basics: Post-Op

In the immediate post-operative period, NSAID’s. For dogs a long-acting opioid such as Recuvyra, or a fentanyl sustained-release patch or for cats an injection of Simbadol a 24 hour opioid that can be repeated with additional injections or sent home with an oral equivalent, and a drug called gabapentin, which helps shut down some of the pain signals to the spinal cord, are all drugs that should be considered.

Pain Sensitivity in Post-Op Tripawd Dogs

But what if your dog has already had an amputation? Depending on each case, there may several issues involved. Chief among them are two problems. The first and most difficult to manage is the development of something called hyperalgesia—an increased sensitivity to pain—that is the result of enduring, untreated pain conditions.

Let’s take a look at the hyperalgesia first. The spinal cord can respond to a constant barrage of pain signals by actually increasing its sensitivity to incoming pain signals and by recruiting non-pain-sensing nerve fibers, such as those used for touch, and turning them into pain fibers as well. These changes can become permanent if not treated, and maybe even if they are treated. If I have a patient with hyperalgesia I do several things:

I make sure that I am correcting the underlying cause of the initial pain, if still present.

I use gabapentin, a drug that not only blocks pain signals , but actually modulates a brain cell called a glial cell, which is implicated in chronic pain states.
I use amantadine, a drug used primarily for treating Parkinson’s disease, to shut down a pain pathway within the spinal cord called the NMDA pathway.

I use an NSAID to help control pain and inflammation at many levels of the pain pathway from nerve ending up to the brain.

I hope this helps, please let us know what the vet says.

Attempt to add the list of meds you originally sent: