Just a followup. The vet reached back out to me and the "off label" drug is Trametinib look it up. It is a very interesting study or drug used specifically for histiocytic sarcoma. Although the cost is nearly 400 a month and they have to meet certain criteria. I think I may try a month or two in all honesty to see if her tumor shrinks and maybe the information could be useful to other members now or in the future. Unfortunately at some point I am gonna have to draw the line financially. She has had a great life, Im just blessed I was able to give her that opportunity .  Many are unable to do the same. I will keep you posted if that is the route I take. I am also gonna add turkey tail to the mix

Mekinist seems to be the brand name and is FDA approved. What I dont understand is why wouldnt they allow that treatment on the first go around if its specifically designed for this type of cancer. Why waste my and Coco's time and money on a particular drug if it doesnt have a high success rate statistically speaking. Why did I have to spend tons of money on that. Why couldnt I have had the  choice on which drug may have seemingly been a better choice for this specific type of cancer. Realistically speaking its the same cost as the lomustaine treatments. 300 every 3 weeks for lomustaine and 375 a month for the trial drug. Sometimes you gotta wonder if its all a money grab. Very frustrating. (Rant over) I was talking it over with a very good friend of mine who has had his share of heartache when it comes to his dogs and trust me he spares no expense on them either. He has a very logical and realistic expectation and understands the situation and really helps me more than he knows. As we talked I feel like I need to at least try this trial not only for myself, but I feel somehow this will help somebody else and knowing that helps me with giving it a try. 

Don't tell her she has cancer. Coco doing her thing.

Shes fiersome

Thanks all. She certainly is a special lady. With any luck she starts her trial tablets next week.  The vet called today asking how she was doing, so far so good i told her. She didnt feel giving her the turkey tail at this point is going to harm anything. I did ask her how long she may have and her response is there really is no telling with out knowing if it has spread beyond where the tumor on the lymph node was without needle aspirations of the liver and spleen etc. She agrees at this point its not really worth the prodding as it does not change treatment. She stated that they have only had one other dog with the trial tablet and she said the had for lack of better words fairly fair results. I have her on her rimadyl which she has been on for 3yrs. Just put her on the gabepentin she is prescribed up to 800mg a day she suggested starting with the least amount as possible so I started her on 100 and had good results, but 200 is where we are at now and seems to be the sweet spot for now. She did also say labs seem to in her experience be very happy an active until that one day where they stop eating and have had enough. Lets hope that day is many days from now. I will continue to try to keep you guys updated on how the trial tabs work. As I explained to the vet at this point I am not only doing this for her quality of and myself, but the many others that may stumble across my post and at least know about the trial drug exist and maybe some real time results. Stay tuned.

P.S. You have any tips on getting a urine sample. She is very picky when using the restroom. She wont even go when on a leash. She lives on a farm and has full roam to go wherever she pleases which makes a urine collection near impossible. Stool sample no problem