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Caring for a Three Legged Dog or Cat

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Any one heard of Mesatinib??
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Oregon
Forum Posts: 198
Member Since:
19 September 2009
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20 September 2009 - 1:39 pm
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This is off my other post but, thought maybe I could address this as a seperate issue. My vet has offered us a trial for the Mesatinib study, it is apparently had excellent results in sarcoma cancers. It has not been used in Osteosarcoma patients.  I have tried to google the name but came up empty.  But it is a tyrosine kinase inhibitor which is to prevent tumor growth. I am not sure though that since she hasn't shown signs that the cancer has metastasized that this is a good option for her at this time. Or if since most times it doesn't show up at the time of amputation that it has moved to the lungs that we should go ahead and give it a shot.

Thoughts anyone???

Shilo diagnosed with osteosarcoma 9/4/2009, amputation 9/9/2009. ShiloAnne lost her battle 11/23/2009 where she regained her fourth leg and is patiently waiting for her parents to join her. We will always love you baby girl.


Forum Posts: 2008
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20 September 2009 - 6:03 pm
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This drug is very similar to Palladia (an animal drug) and Gleevac (human drug) in that they are all tyrosine kinase inhibitors.  They have all been marketed and developed for mast cell tumors (mastosarcoma) but may also help prevent microscopic spread of other sarcoma or carcinoma tumors. 

The main issue seems to be side effects including vomiting, diarrhea, low WBC count, or elevated liver enzymes.  I have not used any of these so you might want to see what type of side effects your vets are seeing.  I plan on trying Palladia for Tazzie but only if we see lung mets.

Pam and Tazzie

East Bay, CA
Forum Posts: 186
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20 September 2009 - 10:12 pm
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Caira Sue is on a study through UC Davis for inhalation Gemzar. I found the most information by googling for the study itself. Maybe this will help?

For us, we didn't want to have too many side effects and Gemzar had low side effects. I think Diarrhea and nausea are the rarely noted, and we really don't see much. Every once in awhile she gets a little gassy and has diarrhea. But she's always had an anxious stomach so it's hard to tell.

Also, I feel good about doing the study because I have faith in my physician and the facility. I have no doubt about his belief in doing what's right for our dog. So make sure you feel good about all that before entering the study. It will help when you start to doubt yourself on down the road. There's so many paths to travel on this journey. You need to feel good about your decision.

It's nice to see so many people involved in studies on here. It's only through studies that we can help future canines fight cancer and have better chances at surviving longer and higher quality lives. Ok, run on sentences mean it's time for me to go to bed!

Mary

May 2001-Jan 21, 2010.....I'm a dog and I'm AWESOME!..... Always.

The Rainbow Bridge



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21 September 2009 - 10:26 am
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shiloanne said:

My vet has offered us a trial for the Mesatinib study, it is apparently had excellent results in sarcoma cancers. It has not been used in Osteosarcoma patients.  I have tried to google the name but came up empty.


Thanks for bringing this up. We haven't heard of it but did a search (it's spelled “Mastinib” which is possibly why you came up empty? Pam, correct us if we are wrong), and found this info:

1st Anticancer Drug For Animals Offers Human Treatment Possibilities

Masitinib is Safe and Effective for the Treatment of Canine Mast Cell Tumors

Dr. Dressler also commented on this, see Comment #93 on his blog post, Mast Cell Tumors in Dogs: some advances in conventional care

Hope this helps.

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Oregon
Forum Posts: 198
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22 September 2009 - 10:33 pm
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Thanks you for the information, this at least gives me a starting point. There is just so much information to digest and so many diffrent options to do. I just want to make the right one for the quality of life and time for her. It seems this maybe a good option, I will make sure to address all of the side effects that it can possible have.

Shilo diagnosed with osteosarcoma 9/4/2009, amputation 9/9/2009. ShiloAnne lost her battle 11/23/2009 where she regained her fourth leg and is patiently waiting for her parents to join her. We will always love you baby girl.

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