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Caring for a Three Legged Dog or Cat

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Clinical trial for OSAin Colombia, Missouri (pre amputation)
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Member Since:
17 May 2014
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20 May 2014 - 4:31 pm
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So, I’ve cancelled Sam’s surgery for tomorrow in lieu of traveling to Colombia, Missouri next Thursday to see if he can participate in a clinical trial the would pay (yes, almost all of it) for chemotherapy for Sam. They’re testing a new not-yet approved drug called CycloSam. Yes, it’s radio active. But in the process, I figure we’ll learn a lot. I have to pay for a bone scan ($300). And if he’s a candidate, we get free chemo, radiation, followups and we *may* not have to amputate. Or, we will know at least how he’s going to respond.

There are lots of exclusionary factors and I have had most of them ruled out before making the (2 hour) journey. So, if you could keep your fingers, toes and paws crossed that Sam can participate, I’d appreciate it. I also feel that if we can help further medicine in this way….just a little bit…and also get some benefit from it, I’m all for it.

Here’s the information, in case there are others in my area who might be interested (http://www.cvm…..rrent.html):

CycloSam™ (Sm-153-DOTMP) OSA Study is a study that involves an IV injection of a radioisotope (CycloSam™) to assess maximum tolerated dosage and the efficacy in canine osteosarcoma patients. Patients will receive a dose of CycloSam™ and be assessed by neutrophil counts to determine recommendations for combination chemotherapy. Dogs will be housed in the radiation isolation ward (5-7 days) until their radioactivity has decreased to a level that is acceptable. A secondary endpoint of this study will be subjective assessment of pain palliation.


Dogs with radiographically-demonstrable osteosarcoma confirmed by biopsy or cytology with ALP staining.
Adequate renal, hepatic and hematopoietic parameters with no significant co-morbidities.
CBC, Chemistry panel, UA, Bone scan and thoracic and affected limb radiographs at first visit
Bone scan must demonstrate adequate uptake of technetium
No soft tissue or bone metastasis
No pathological fractures
ONLY tumors of radius, humerus, tibia and femur will be considered
No previous chemotherapy or radiation therapy
NSAIDS allowed if started 2 weeks prior to study enrollment

One time intravenous infusion of CycloSam™ , blood-work weekly for at least one month
Periodic owner assessment of patient’s activity and pain response
18FDG PET at Day 1 and Day 28
Carboplatin and blood work every 3 weeks x 4 treatments
CBC’s one week post chemo x 4 treatments

Owner to pay initial office call, once enrolled study is fully funded. This includes nuclear medicine scans, Cyclosam™, radiation isolation, weekly follow up and blood work, chemotherapy.
Contact Faculty Person: Dr. Kim Selting
– See more at: http://tripawds…..n/#p126207

Katie, human momma to Sam, a 9 year old yellow lab who stole my heart. Diagnosed with OSA 4/17/14. Entered CycloSam study at University of Missouri which did not hinder tumor growth. Sam fractured his leg at tumor site on 7/2/14 and was exited from the study. Amputation surgery 7/8/14. Lost his battle 9/25/14. Forever in my ❤️
Also in the menagerie:
Maizie a 1 year old schnauzer
Luna, 15 year old siamese-mix kitty

DD- 6 years old and full of questions
DS 4 years and full of energy

Blogging about this here:

On The Road

Member Since:
24 September 2009
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20 May 2014 - 8:54 pm
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Thank you so much for sharing this study and all the details. We wish you two all the love & good luck in the world, please keep us posted and remember we’re here to help however we can. Mizzou rocks, they’ll treat you well!

Tripawds Founders Jim and Rene | | |

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