Caring for a Three Legged Dog or Cat
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kilosam said:
Has anyone had experience with Palladia?
Did you try searching the forums for Palladia? Here's a few existing topics that stand out...
Questions about lung mets and palladia
Alexander Dane Lung Mets Update (Reply by Dr. Pam)
metronomics or palladia for hemangiosarcoma
Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet
FYI: You can also search all Tripawds blogs here.
Looks like Abby is taking Palladia.
Mackenzie was also started on Palladia after lung metastases appeared.
Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet
Kevin,
Here are some links outside Tripawds to check out:
Rosie's Road, the story of a yellow lab with mast cell cancer who has been on Palladia for along time. Scroll down- there are lots of links to information on mast cell and palladia.
Canine Mast Cell Cancer, a Yahoo group for people and their pets fighting MCT. You have to join, it is not as easy to navigate as Tripawds in general- but everyone there has some level of experience with mast cell in their dogs.
Dr. Dressler's Review of Palladia- there is a link here to the original study information. Warning- Dr.D in this review did not think much of palladia.
I looked into palladia a little- and didn't like what I read about the side effects. But there seem to be many dogs tolerating it just fine.
In some reading I saw that palladia only works, or works better in dogs with a certain mutation in the mast cell tumors. I read a couple of places that it is effective, or most effective in 40% or so of cases. There is a test that can be done on the tumor to see if your dog is in that category. Here is the technical lingo:
Palladia is in a family of drugs called receptor tyrosine kinase (RTK) inhibitors.
In a normal cell, cellular growth and proliferation is tightly controlled by RTK's that are found on the cytoplasmic or nuclear membrane of the cell. In malignant cells, there are mutations that cause these RTK's to be constituently activated, leading to unregulatedgrowth of these cells.Palladia is a small molecule that fits into the receptor site of certain RTK's and then blocks kinase activation. Kit is a receptor that is found on the surface of mast cells and C-kit, the gene for this receptor, has been shown to be mutated in 20-30% of all mast cell tumors. Dogs with tumors that have this mutation are known to have a poorer prognosis. Palladia has been developed to be a specific inhibitor of kit. Dogs with c-kit mutations and no lymph node metastasis were more likely to have a response to Palladia.
I'm not advocating for palladia, or trying to talk you out of it. You and your vet need to decide what is the best course of action to give Sadie the best chance. I am just sharing the info I found while researching palladia.
Karen and the pugapalooza
One of the tests that they ran on Rio's latest tumor was for protein mutation. If the tumor showed signs of mutation, then the doctor was going to have Rio take Palladia. Since it didn't show this mutation, she had us do CCNU and Vinblastine. I did do some research on Palladia, and the side effects didn't seem that much more severe than what we're taking, just different. Granted the side effects with the current chemo could have been way worse than what we're experiencing -- one of the dogs that we ran into at the Drs had such severe side effects with Vinblastine that he nearly died. We've been really lucky! Side effects with these medications definitely vary from dog to dog, and you just have to gather as much information as you can, and then just trust yourself with your decision.
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~ ~ Rio ~ ~ |
Oh, one more thing... One of the other considerations about Palladia is that it is a much longer course of medications, and since it's new, it's also fairly expensive. You might see if you can get your pup onto one of the many clinical trials out there if you end up going with Palladia. If your vet doesn't know about them, I found a couple at Colorado State and a few of the other major veterinary schools. Just do a Google search.
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~ ~ Rio ~ ~ |
riosmom said:
...many clinical trials out there... I found a couple at Colorado State and a few of the other major veterinary schools.
Check out Jerry's article about Clinical Trials from our tour of CSU, and you'll find a list of many clinical trials going on around the country on the News blog Resources page.
Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet
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