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HELP - 14 days post Carboplatin administration CBC results, 14K platelet value
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Member Since:
18 November 2022
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1
2 February 2023 - 1:17 pm
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Hi - hoping someone can give me some insight... our GP vet is out of his depth and was informed by our oncologist to consult him prior to any treatment; but our Oncologist (one of 3 in my province) is not in the office this week because they're moving facilities... cue my panic.

Boone is a neutered 5 year old mastiff x; diagnosed with osteosarcoma Nov. 17th; received 27Gy SRS treatments (9x3) Dec. 12-15; received biphosphinate infusion Dec. 16; started carboplatin (498.9mg IV) on Dec. 28th; 10 days post CBC showed low neutrophils (2.3); adequate platelets (103).  Received second dose of carboplatin (498.9mg IV) on Jan. 18th; CBC that day indicated Grade I neutropenia (2.42); adequate platelets (187).  

Follow up CBC on day 14 post 2nd chemo administration had the following results:

RBC 7.1 5.4 - 8.7 x10E12/L

Hematocrit 0.46 0.38 - 0.57 L/L

Hemoglobin 160 134 - 207 g/L

MCV 64.8 59.0 - 76.0 fL

MCH 22.5 21.9 - 26.1 pg

MCHC 347.8 326.0 - 392.0 g/L

RDW 13.9 10.0 - 19.0

% Reticulocyte 0.2 %

10.0 - 110.0

x10E3/uL

Reticulocytes 14.2

Reticulocyte 24.5 - 31.8 pg

Hemoglobin

26.9

WBC 5.9 4.9 - 17.6 x10E9/L

% Neutrophils 59.8 %

% Lymphocytes 19.8 %

% Monocytes 0.7 %

% Eosinophils 19.5 %

% Basophils 0.2 %

Neutrophils 3.5 2.9 - 12.7 x10E9/L

Lymphocytes 1.2 1.1 - 5.0 x10E9/L

Monocytes 0.0 0.0 - 1.2 x10E9/L

Eosinophils 1.2 0.0 - 1.5 x10E9/L

Basophils 0.0 0.0 - 0.1 x10E9/L

L Platelets 14 143 - 448 x10E9/L

Platelets appear severely

decreased (< 25 x 10E9/L).

Mild platelet clumping observed

NO CLOT

My question is - does he need immediate intervention? Presenting as normal energy/appetite; capillary refill normal; normal gum color; no observed burst vessels in mouth/gums/on belly.

Straight up panic staring at him (and probably confusing him in the process).  Any insight very much appreciated!

The Rainbow Bridge



Member Since:
25 April 2007
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2 February 2023 - 4:36 pm
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Paws crossed that Dr. Pam can offer some insight on this. Glad you posted here.

I wish I could help, but I'm just a vet and am not knowledgeable in this department. But what I can say is: keep calm and hop on! He's looking at you to lead the mood, and so the calmer you are the more he will be too!


Member Since:
22 August 2008
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2 February 2023 - 9:59 pm
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I did reply in your other post but this is not an issue and the bone marrow should recover.

Pam

The Rainbow Bridge



Member Since:
25 April 2007
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3 February 2023 - 10:09 am
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Thank you sooooo much Dr. Pam!

Here is a link to the other post for those following along:
https://tripawd.....s/#p252713

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