My dogs name was mickey. he was a miniature schnauzer,neutered at 6 months. when he was 9 years old (04/14/2014) he wasdiagnosed with hemangiosarcoma. they said it had been going on for about 2 months i had caught it early. the cancer was in the humerous bone in his right front led. his leg was amputated and he went thru 6 rounds of chemo (carboplatin/diroxicubin) then he was put on metronomic therapy (cytoxin and piroxicam). he would get checkups every 3 months at the Uof M VMC hospital with an oncologist. this continued for 2 years and 6 months no evidence of spread of cancer. after this time he had surgery he had surgery to remove his gallbladder. the surgery was fine.5 weeks later i noticed he had a pink drop of urine on his bed. i took him to the vet. they said his bladder stones had returned andhe would need surgery to remove them. they had done an ultrasound on his bladder. i chose a lithotripsy and my dog would have towait a month to have the proceedure. in that month he developed sterile hemmorhagic cystitis. it is a side effect of the drug cytoxin(cyclophosphamide). i stopped the cytoxin 4 weeks too late and the damage was done. the lining of his urinary bladder was very inflamed i had to put a diaper on him he had hematuria he was peeing clots and he had a huge blood clot in his bladder. i gave him time to improve but the blood was not decreasing and he would require numerous transfusions the process could take months and he might not get better. he had one transfusion and 4 days later he would require another transfusion. i decided it was time to put him down. he had been off the cytoxin for 3 weeks and was not getting better. a necropsy was done. there was no evidence of any cancer spread. i would like to know if anyone else has had to go thru this? and if anyone has a dog that is currently on metronomic therapy that includes cytoxin please monitor your dogs urine carefully. the SHC is a nasty disease. it is sneaky, develops fast, is horrific and can be deadly.