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Breed-Specific NSAID Reactions?
26 March 2009
1:48 pm
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The good Doctor Dolittler, Patty Khuly, VMD just wrote about an English Mastiff who died from toxic reactions to Metacam. However, Jerry took Metacam daily for nearly two years after his amputation with no apparent side effects.

Is it known if certain dog breeds have different reactions to specific medications – specifically NSAIDs – or are all dogs just different?

"Dogs are born with three legs and a spare."
— Jerry G. Dawg (10/98-10/08)
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26 March 2009
7:21 pm

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The only possible breed-specific problem I have heard of is with Labradors and Rimadyl.  Many Labs have been reported to have liver issues with this drug but it is hard to say if it is a real problem or if it is just that so many Labs take Rimadyl so you see a higher incidence.  The safest way for any dog to take NSAIDS is to have a baseline blood test taken before starting the drug, then repeated 2-4 weeks after starting the meds then every 6-12 months thereafter.  I have been monitoring Tazzie's blood every month (due to her pre-existing liver disease) and so far, so good.  Today is actually her 7 month anniversary since surgery!

Pam and Tazzie

26 March 2009
7:30 pm
The Rainbow Bridge

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tazziedog said:

 I have been monitoring Tazzie's blood every month (due to her pre-existing liver disease) and so far, so good.  Today is actually her 7 month anniversary since surgery!

Pam and Tazzie


SEVEN MONTHS?  HOOOORAAAAAY!!!!!!!!

Wow, time flies. We are thrilled for you both, and are truly happy to hear this great news. Many big congrats!

It's better to hop on three legs than to limp on four.™
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30 March 2009
11:47 am
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I just found this link for pet pharmacy information in a newspaper column…

"The information provided in the Pet Pharmacy Library of Medications is a list of medications commonly prescribed for the treatment of dog and cat medical conditions. Information in the form of medication information sheets is provided by both brand name and generic name."

Each medication listed links to its own information page with helpful details including usage, side effects, and other concerns. Here are the direct links to important information about:

"Dogs are born with three legs and a spare."
— Jerry G. Dawg (10/98-10/08)
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13 May 2011
3:19 pm
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Wow , thanks for the information. What is considered long term? Benji has been on Rimaldyl since the 13th of April and now 7 days past surgery. The prescription was only for 5 days after surgery so I will have to see how he feels tommorow without it. How often do they really need this? He gets his stitches removed on Monday and then the chemo will start.

13 May 2011
3:56 pm
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It may all depend on the dog, and the drug. Jerry did well on Metacam for more than a year, whereas Rimadyl and Previcox both tore him up inside within a week. Hopefully Pam can provide a professional opinion.

"Dogs are born with three legs and a spare."
— Jerry G. Dawg (10/98-10/08)
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13 May 2011
11:43 pm
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My Comet was on Rimadyl for 1 year and a half with no problems.  She was around 11 years old when she went on it but she had been hopping on 3 legs all of her life.  She didn't have cancer.  

I'm a firm believer that if they need it to feel better, give it if there are no side effects.   

Her Retired AvatarComet - 1999 to 2011
She departed us unexpectedly  January 23, 2011 at the age of 12 1/2.
She was born with a deformed front leg and a tripawd all of her life.
14 May 2011
5:52 am
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Trouble showed elevated liver enzymes with Rimadyl.  They were not extremely high, but she was taken off Rimadyl at that point.  As her arthritis progressed, we gave her minimal doses to keep her comfortable working up to a full dose daily for about three months before the end.

I know most of us don't want to over medicate, but if it helps them get along better and there are no adverse effects from the drug, I'd got with it.  Another option is to see a holistic vet and get some advise.

Shanna & Spirit Trouble ~ Trouble gained her wings 3/16/2011, a 27 1/2 month cancer survivor, tail wagging RIP sweetheart, you are my heart and soul.  Run free at Rainbow Bridge.
We honor our fellow November Five members who will always remain forever in my heart: Nova – the lone survivor, live proud and long; Spirits Max, Cherry, & Tika – who made half the journey with us and greeted Trouble at the Bridge
http://k9cancer.org – a canine cancer support community
14 May 2011
8:15 pm

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I consider long-term use of an NSAID to be daily for more than a month at a time.  Many dogs take these drugs without problems but you have to monitor the bloodwork to know if there might be organ dysfunction.  I have also treated many dogs that have elevated enzymes on 1 drug but not another.  I like meloxicam the best because it seems least likely to cause stomach or liver problems but the tablets can only be used in larger dogs and the liquid can be pricey.

Pam

15 May 2011
12:42 pm
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Thanks everybody..will ask the vet. Benji is losing protein in his Urine and I am afraid that Rimadly and Chemo together may ruin him.Gonna try Accupuncture to help reduce the pain in his joints.

15 May 2011
5:16 pm
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neysha said:

Thanks everybody..will ask the vet. Benji is losing protein in his Urine and I am afraid that Rimadly and Chemo together may ruin him.Gonna try Accupuncture to help reduce the pain in his joints.

ETGayle is a big supporter of accupuncture.  By the time I located an accupuncturist locally, Trouble only had one treatment before we were forced to make quality of life decisions.  I had high hopes it would make a big difference for us. Overall, I think there are several folks here who use accupuncture regularly with great success.

Shanna & Spirit Trouble ~ Trouble gained her wings 3/16/2011, a 27 1/2 month cancer survivor, tail wagging RIP sweetheart, you are my heart and soul.  Run free at Rainbow Bridge.
We honor our fellow November Five members who will always remain forever in my heart: Nova – the lone survivor, live proud and long; Spirits Max, Cherry, & Tika – who made half the journey with us and greeted Trouble at the Bridge
http://k9cancer.org – a canine cancer support community
7 March 2012
9:07 am
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FYI: New Fully Vetted blogger Dr. Jennifer Coates has published an update on this important subject:

Advice to Dog Owners Whose Pets Take NSAIDs

"Nonsteroidal anti-inflammatory drugs (NSAIDs) work by decreasing prostaglandin levels in the body. They do this by inhibiting the enzyme cyclooxygenase (COX), which in turn is responsible for turning arachidonic acid (a fatty acid) into prostaglandins…

…If your dog has an adverse reaction to an NSAID, stop giving the drug and call your veterinarian immediately. Adverse reactions need to be reported so drug safety can be monitored. Directions on how to do this is available at the FDA’s Report a Problem website."

"Dogs are born with three legs and a spare."
— Jerry G. Dawg (10/98-10/08)
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Have you started a Tripawds Blog yet?
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