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Chemo finished now what?
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UK
Member Since:
2 August 2015
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27 January 2016 - 9:36 am
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Hello everyone

I am wondering what experience people have had with using Masivet once all the carboplatin (or whichever protocol you follow) is done

We have had 6 sessions of Carboplatin (last one was on Monday) and are now being recommended Masivet which apparently is being used, but not as far as I can tell trialled properly, for osteosarcoma.

I am being told that it is in the form of a daily tablet, with regular blood tests. There doesn't seem to be anything official being done regarding its use for this tumour (it was developed for mast cell tumours) but that it might make a difference to extension of life

Has anyone any experience please, we are researching whether or not to try it

At the moment my inclination is that Jack has, so far, tolerated everything well (although he has looked a wee bit 'sad' the last couple of days but maybe his tummy hurt as he was sick this morning and looks happier this afternoon) so there is no reason not to try and we can stop it if he reacts badly, but equally if there is no evidence it does anything why would we and then again why wouldn't we?

Help!!!!!whatever

Judith and Jack

http://jackdog......pawds.com/

 

not forgetting Pepper, Storm, Finn and Solo too

 

http://www.toll.....lers.co.uk

On The Road


Member Since:
24 September 2009
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27 January 2016 - 10:50 am
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Wooohooo! YAY for knocking down all six chemo sessions, that's pawesome! clap

Interesting about the Mastinib/Masivet/Kinavet recommendation for osteosarcoma. Here are some Tripawds Forum search results about others' experiences or questions about this type of treatment. Not sure if any were using it specifically for osteo or not, usually it's for Mast Cell Cancers.

You're right though, I don't see it being prescribed for osteo when I search online, but it's a new drug and this type of newer use makes sense since Palladia, another targeted therapy in the same class of drugs, is now being used for this type of cancer. If you can get any research papers from your vet about mastinib and osteo that would be great, and if so I'd love to hear more.

And you're right again, you can always stop if Jack doesn't tolerate it well.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Virginia







Member Since:
22 February 2013
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27 January 2016 - 4:28 pm
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JAAAACK!!! Way to rock that chemo kiddo!!!

The "what next" is such an individual decision with no right or wrong.

How does Mac handle trips to the vet? How do YOU handle "second guessing"? Do you feel at peace at this point knowing you have done all that can be done medically? Do you feel "unsettled" thinking there is more that can be done medically?

Curious about the statement that (paraphrasing) it may make a difference in extension of time. Was that just the Onco's "guess" or was there any backing for that statement?

Have a "conversation" with Mac. Get in a calm and centered state and "listen" to wnat he says.

Now give him a special treat for sailing through the chemo!!clap

Jack, you are doing a great job...and so is your human!!

Love!

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

UK
Member Since:
2 August 2015
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28 January 2016 - 10:05 am
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I guess because I can find so little about the treatment and no one seems to be saying anything about their experiences its difficult to decide

I feel that IF they said they were researching into it and his experience would help I wouldn't hesitate but at the moment it seems like a bit of a random 'we could try this' kinda moment with no solid evidence that it is something that would help, although in Mast Cell it apparently does

Grrr - how on earth do you decide, we are supposed to be their advocates and do the right thing for them

If it helps it is known as Kinavet in the US

(now I can read some of the relevant blogs)

Judith and Jack

http://jackdog......pawds.com/

 

not forgetting Pepper, Storm, Finn and Solo too

 

http://www.toll.....lers.co.uk

On The Road


Member Since:
24 September 2009
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28 January 2016 - 11:42 am
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I hear ya. You know an onco once told me that all oncology / cancer treatments are much the same way. She described is as like cooking spaghetti, and doing that old trick of throwing it up on the ceiling to test for doneness. If the pasta sticks, you know it's cooked and you've achieved success. If it falls off, you try again. Treating cancer is a lot like that.

You are dgoing a GREAT job being an advocate just by asking questions, never doubt that you aren't.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Maryland
Member Since:
28 March 2015
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6
28 January 2016 - 12:10 pm
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I had actually typed up a response much like Jerry's (which of course just this once I did not copy prior to submitting! Oh, well). 

Mostly, I had posted to say that we'd all like to know we have a good reason (aka data) for trying something. But more often than not, what we up doing is simply taking a leap of faith. The number of owners who are willing and able to try chemo for their pups is still just very small. A lot of what we know seems to be very empiric---a vet will try something and depending on the results they see they'll either recommend (or not recommend) a given drug or protocol. We all hope we're not doing actual harm, but we'll never know whether the outcome would have been the same (or better) if we had done something different. We just have to live with that uncertainty. 

When we finished Carbo6 with Ellie, we were given the option of continuing w/ a metronomic therapy (Palladia). We decided against it, based partly on the vet's experience, partly on just being tired of having vet visits and wanting to "go back to normal". There is no right or wrong decision here, just hope and love.

Denise, Bill and Angel Ellie.

Active 10+ Pyr mix suddenly came up lame with ACL tear in left rear leg. Scheduled for a TPLO but final pre-op x-rays indicated a small suspicious area, possibly OSA, which could have caused the ACL tear. Surgeon opened the knee for TPLO but found soft bone. Biopsy came back positive for OSA. Became a Tripawd 9/18/14. Carbo6 with Cerenia and Fluids. Pain free and living in the moment. Crossed the Bridge on 7/12/15 after probable spread of cancer to her cervical spine. A whole lifetime of memories squeezed into 10 months. Here's her story: Eloise

UK
Member Since:
2 August 2015
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6 February 2016 - 2:12 pm
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Still completely undecided about what to do

there is the 'fed up of going to the vets' feeling bit also the 'will it help him' feeling

there is so little information about people experiences with using this drug to treat Osteo

Judith and Jack

http://jackdog......pawds.com/

 

not forgetting Pepper, Storm, Finn and Solo too

 

http://www.toll.....lers.co.uk

Green Bay, WI


Member Since:
18 May 2014
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6 February 2016 - 5:58 pm
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We did do metronomic therapy for Nitro, but it was Cytoxan. He was on it for about 10 months before it caused cystitis and we had to stop. It really does seem to be a crap shoot whether or not to continue, or what to use. I'm not sure if I did it to make me feel better or to help him, to be honest. So I guess you have to follow your heart to figure this out. Good luck!

Paula and Nitro

Nitro 11 1/2  yr old Doberman; right front amp June 2014. Had 6 doses carboplatin, followed by metronomic therapy. Rocked it on 3 legs for over 3 years! My Warrior beat cancer, but couldn't beat old age. He crossed the Bridge peacefully on July 25, 2017, with dignity and on his terms.  Follow his blog entitled "Doberman's journey"

http://nitro.tripawds.com

"Be good, mama loves you".....run free my beautiful Warrior

Member Since:
20 January 2016
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6 February 2016 - 7:23 pm
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YAY!! Way to go Jack!!! xo

Charlie and his mamma

On The Road


Member Since:
24 September 2009
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10
6 February 2016 - 9:18 pm
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It's really a hard call, but ultimately what is best for him is whatever makes the whole pack happy. Happiness and quality of life are the most powerful medicines out there.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

UK
Member Since:
2 August 2015
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11
18 February 2016 - 11:44 am
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We have our referral appointment to the vet hospital to talk about the next medication, be interesting to,see what they say particularly since the drug has been withdrawn for those of you in the States, we are going on a small trial they are doing in this country

Judith and Jack

http://jackdog......pawds.com/

 

not forgetting Pepper, Storm, Finn and Solo too

 

http://www.toll.....lers.co.uk

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