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Caring for a Three Legged Dog or Cat

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Antibody treatment for arthritis
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London, UK


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8 March 2019 - 12:05 pm
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Has anybody heard of this? Apparently it’s undergoing trials at the moment for both humans and animals, and initial results are extremely encouraging – a monthly injection (in the back of the neck, not the joint) and it blocks the inflammatory response in the arthritic joint. Meg’s rehab vet, who we saw today, expects it to be generally available in the next year or two.

Meg now has arthritis in her hock. Only to be expected, I realise, given her age and three-leggedness. In fact, we are probably fortunate that her back legs have been arthritis-free up until now. Unlike her front one, which is really pretty bad. On the plus side, Galliprant has FINALLY been licensed for use in the UK and will be available imminently. Fingers crossed, it works well for her.

Anyway, just wondering if anyone has heard about the antibody business. I found this paper about it, and apparently it’s being trialled in North Carolina. 

Meg, Clare and Angel Pie ❤️❤️❤️

Meg, Mutt, aged around 10, adopted 31/12/2009. Sudden explosive right elbow fracture 06/12 (caused by IOHC), diagnosed with End Stage Arthritis 03/15, Total Elbow Replacement 08/15, problems with healing leading to skin graft & skin flap surgery, Chronic Infection leading to implant breakdown. Became a Tripawd 9th March 2016. 
Lives with Mum, Clare, watched over by Angel Pie and Angel Billie
My life as a MEG-A-STAR 


The Rainbow Bridge



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8 March 2019 - 5:43 pm
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You have one excellent physio therapist Clare! I’m curious if she’s on the team at Canine Arthritis Management, because they are one of the few resources that mention monoclonal antibodies for dog arthritis on their treatment options page (see bottom). 

I haven’t heard about this, but I’m definitely going to ask Wyatt’s therapist Sasha Foster, when we see her in May. Apparently the technology of this personalized medicine has been around for a while in veterinary medicine, for conditions like atopic dermatitis in dogs, but not for arthritis. And although it appears to have started in North Carolina, it seems to be more frequently mentioned in the EU. 

Wyatt also has OA in his hock, and we are very curious so thank you for bringing this to our attention.

For Reference:

Monoclonal antibodies make leap to veterinary medicine

There is potential for application to many more chronic veterinary diseases. Monoclonal antibodies could be beneficial for supporting diagnosis and therapy of cancer in veterinary oncology and some believe they will be part of standard care for canine lymphoma within five years.

In the 40 years since their discovery, there has been a focus on the potential of monoclonal antibodies in human medicine. The launch of Cytopoint marks the first step for monoclonal antibodies in veterinary medicine in the EU, but the potential stretches far beyond canine atopic dermatitis. In future, monoclonal antibodies may come to be commonly used for the treatment of infectious diseases, cancer, immune diseases, and arthritis – in human and veterinary medicine.

It's better to hop on three legs than to limp on four.™
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Livermore, CA




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8 March 2019 - 9:50 pm
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Very interesting Clare, thanks for posting.

I would have been all over something like this when Tani was around.  I don’t see my rheumatologist for a couple months but I’m going to put a note in my phone and ask him what he knows about this therapy.

Karen and the Spirit Pug Girls

Tri-pug Maggie survived a 4.5 year mast cell cancer battle only to be lost to oral melanoma.

1999 to 2010

 

              Maggie's Story                  Amputation and Chemo

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9 March 2019 - 12:31 am
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Thanks for responding. It does sound pretty exciting. I just hope it will be available in time for Meg but it is great to think of the options that may be available for animals and humans in the future. 

Philippa is nothing to do with Canine Arthritis Management, no. Her Practice is called Active  Pet  and she’s great, highly conscientious and very well-informed. I also think it’s useful that Megs been seeing her for so long – at least monthly for more than three years. This means she knows Megs body extremely well and can immediately detect any areas of tension, or changes, the slight thickening in her hock, for example. 

I don’t know whether it’s an EU thing or just down to individual vets and it’s all so interconnected anyway. Philippa is British and did her veterinary training in the UK but actually did her specialist rehab vet training in the US (Tennessee) And in a months time we won’t be part of the EU anyway, with potentially catastrophic consequences for veterinary treatment and the availability of medications in the UK, but that’s another story (sorry…)

Meg, Mutt, aged around 10, adopted 31/12/2009. Sudden explosive right elbow fracture 06/12 (caused by IOHC), diagnosed with End Stage Arthritis 03/15, Total Elbow Replacement 08/15, problems with healing leading to skin graft & skin flap surgery, Chronic Infection leading to implant breakdown. Became a Tripawd 9th March 2016. 
Lives with Mum, Clare, watched over by Angel Pie and Angel Billie
My life as a MEG-A-STAR 


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9 March 2019 - 8:31 am
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I hope she (and Wyatt) can benefit from the treatment as well. I love that Philippa was trained at UT, she is a rock star! And yep, having a long-term relationship with a therapist makes such a big difference in a Tripawd’s life over time. It’s why we encourage folks to get started with one as soon as their dog or cat loses a leg.

Oh my gosh try not to worry about the coming changes in Britain, you have enough on your mind! I know, easier said than done of course, we aren’t in the middle of that mess. We are all thinking of our Brit friends and hoping for the best. 

It's better to hop on three legs than to limp on four.™
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Virginia




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9 March 2019 - 9:27 am
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Cery promising!  Thanks  for sharing!  I’ve got a hound dawg over here who could benefit too…as well as his hooman!!

I’ll be following this thread closely.

❤❤❤❤❤                                                                                                                     

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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