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Caring for a Three Legged Dog or Cat

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Denamarin and/or Marin to help liver?
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Member Since:
24 January 2009
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11 March 2009 - 4:22 pm
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Hi Pam, 

In the past you wrote that you're giving Tazzie both denamarin and Marin to help her liver (if I remember correctly). I've started Marley on the denamarin and just remembered to ask my vet about giving her Marin as well. I just heard back from her - actually the person at the front desk relayed the message - that you would only do one or the other. Just want to make sure my message to her or her message back to me wasn't misunderstood. Does that sound right to you?

Thanks!
Holly and Marley


Member Since:
22 August 2008
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12 March 2009 - 2:25 am
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You can add Marin if the denamarin alone is not suffiicient to control the liver enzymes.  denamarin has SAM-E and milk thistle (silybin) while Marin has milk thistle, vitamin E and zinc.  Some dogs can even be weaned to every other day meds but Tazzie has to take both every day.  Even on the Metacam her liver values are in the normal range. 

Every dog is different so you might be okay with one or the other alone, but if liver values have not improved in 1 month then I would do both.  Adriamycin is not known to be as harmful as CCNU is on the liver but anything is possible with chemo drugs.

How is she doing?

Pam and Tazzie

Member Since:
24 January 2009
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12 March 2009 - 4:33 pm
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Ah, got it. Thank you so much!! I'm eager to see how it affects her liver levels when we do a CBC a week from Wed (Wed is her next round of chemo with the Andriamycin). She's doing great! I keep looking at her and thinking - how can she have cancer?!? she's seems so healthy now. She's hopping all around. Definitely not a lot of activity - her remaining back leg does seem to be weak at times. It will just give out every now and then and she doesn't really fall, but slowly her bum sinks to the floor…and she gets right back up. we're a little worried about her knee (which one surgeon said would be a problem, but the one who did the surgery thought would be fine). I have noticed her muscles in her remaining legs are getting stronger - they are visibly thicker! so hopefully it's just a matter of time (it's been 

They did find a spot on her spleen two weeks ago on ultrasound just before her first chemo treatment. Just trying not to think about it! though wondering what the chance of the chemo responding to it…? 

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