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Carboplatin Extravasation? Or not? Pictures - graphic! Not for the faint of heart.
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dukez
1
17 June 2012 - 2:45 pm
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Just opened a photobucket account so I could post some of the pics of Duke's leg. Hope it works and I hope that maybe the will be helpful to Dr. Pam and others.

For those of you who haven't read my other posts Duke had his left rear amputated due to osteo 11 weeks ago. Was doing *incredibly* well. Had his 3rd round of chemo on Monday June 4. Saturday evening June 9th he started favoring his left front leg. Sunday June 10th he spent all day, and the night, in the ER due to severe swelling in his front left leg. Saw his oncologist Monday the 11th and she noted he had some slight swelling in his right front leg also as well as his chest.

The swelling greatly resolved during the week. Then Friday he started getting sores on his leg.

The photos start from Friday evening (I think, I'm so exhausted they may have been from Sat morning and then Sat afternoon) to this morning (Sunday). The progression was swift and frightening. I have them labeled Day 12, 13, and 14 and those are the days since 3rd round of chemo.

If you have seen this and can shed light on it I'd be most appreciative. As others have said greyhounds have thin skin and that is no doubt complicating things. The questions are when will it stop? How much skin will fall off? If this isn't extravasation what on earth is it? It is confined (so far!) to the leg he got the chemo in. And, can he survive it?

For my poor boy who was just on one med for urinary issues (phenoxybenzamine) just over a week ago, he is now on:  two antibiotics, two pain meds, a steroid (prednisone), famotidine (Pepcid), and pentixifylline. And it feels like I'm missing one.

Again, any thoughts would be appreciated.

[Image Can Not Be Found]

dukez
2
17 June 2012 - 2:46 pm
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Argh.... photos didn't work. Take 2.

 

Here's the link... old style 🙂

 

http://s1240.ph.....kes%20Leg/

On The Road


Member Since:
24 September 2009
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3
17 June 2012 - 8:15 pm
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Ouuuuch. Geez, I don't have any idea what extravasation would look like, but from what I can tell that looks terribly painful. Poor kid! Thanks for sharing the pics though, it's good for everyone to know what that condition might look like.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Orange County, CA
Member Since:
28 November 2008
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4
17 June 2012 - 8:27 pm
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I don't know what it looks like either, but just wanted to send positive thoughts to Duke. I'm sorry to read he's had this setback.  Hopefully Dr. Pam will add her two cents, and hopefully Duke's dr.'s will figure this out and get him back on the road to recovery.  Hang in there, Duke!!

dukez
5
18 June 2012 - 7:17 am
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I heard back from the OSU vet - he confirmed my suspiciions. Sadly Duke is barely breathing this morning so he may not be going to make it through the day. Keep us in your thoughts.

 

I am so sorry to hear. To me, it looks like a perivascular injection of carbo (have seen a couple in hounds that look the same as Duke's). The treatment he is on is what we will use here on the rare occasions we see it. These lesions are usually self-limiting (they resolve on their own), but sometimes the necrotic (dead) piece of tissue needs to be surgically removed. Your vets can prescribe a lidocaine patch, local anesthetic adhesive patch for the area,m to help with the pain. Do you remember how much he weighs? We should be able to increase the tramadol. Let me know.

On The Road


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18 June 2012 - 7:46 am
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Oh Duke! We are so, so sorry. Paws crossed that you can rebound from this bad situation. Please stay strong, we need you here to share your story. Keep us posted OK?

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

In your heart, where I belong.
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18 June 2012 - 11:07 am
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I've not replied but I have been following along. I have nothing to offer except my moral support and hopes that Duke can conquer this. I am unclear on why the missed injection site would cause Duke to tank so hard. Regardless, I hope he can be nursed through this. I'm thinking of him today.

Shari

From abandoned puppy to Tripawd Warrior Dude, Dakota became one of the 2011 February Furballs due to STS. Our incredibly sweet friend lived with grace and dignity till he impulsively raced over the Bridge on 12-15-12.

Dakota's thoughtful and erudite blog is at http://shari.tr.....pawds.com/

dukez
8
18 June 2012 - 11:52 am
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Thanks for the thoughts and good wishes. My dog has more spirit and spunk than I can believe. He is in a "life on two legs" phase right now, but hopefully he can pull through and get back to "life on 3 legs". He continues to hang on by his nails (which are luckily long right now! :).

 

The reason he has tanked so hard Shari is that the chemo, a strong poison basically, was injected into the cells/muscle/etc. rather than into the vein, and it is killing the tissue. If his chemo had been Doxorubicin he would definitely have to be put down because it can destroy muscle, tendons, ligaments, everything right down to the bone. Sometimes with dogs that are 4-legged they will do an amp.

We are already a tripawd so we don't have "3 legs and a spare " anymore. That said, it is amazing to see my dog run on his two right legs - but he needs the third to balance to eat and potty. Duke had carboplatin rather than doxorubicin (thank goodness!) and carboplatin is not supposed to destroy tissue, etc. but clearly it can. And unfortunately he didn't just have a drop leak, he appears to have gotten most of it outside of the vein. Why they can handle it in the veins and not in the muscle, skin, wherever it was incorrectly injected I don't really understand. Veins must be made of amazingly strong stuff! And it is diluted with the blood so I suppose that helps. ? I'll let a vet speak to all that.

 

I'm probably going to start a new thread off the "Ask a Vet" forum just, as "Jerry" said, so others can learn and see how devastating a missed injection can be, can know what to look for, and understand treatment - which is basically just supportive right now in Duke's case. He may, however, have the leg debrided this afternoon. If they do that they can see how deep the damage is, and I am aware I may have to let him go on the operating table if the damage is too extensive. But, as the OSU doc said sometimes it is self-limiting and does not require surgical intervention. I'll let my oncologist and ortho surgeon determine that this afternoon.

 

And, in amongst all this crappy news is the fact that he didn't end up getting any chemo so he got the total lose-lose thing happen.

 

From a financial perspective, I have dropped loads of money into this in the past 10 days and I hope the hospital that made the administration error will pick up the expenses. And if he doesn't make it, the expense of the amp also. This is due to human error. Sucks big time.

San Diego, CA
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29 October 2010
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9
18 June 2012 - 12:48 pm
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Oh my goodness, I hope the OSU doc is right and this will be self-limiting.

I'm so sorry you are in this situation. I didn't even know this was possible. It is definitely important for others/newbies to know.

I sure hope the hospital will take some responsibility for this! But more importantly, I hope Duke can keep holding on by those long fingernails and fight this thing. How frustrating for you! Hang in there, we are sending out our best pawsitive thoughts!

Jackie, Angel Abby & MBBunny Rita

Abby: Aug 1, 2009 – Jan 10, 2012. Our beautiful rescue pup lived LARGE with osteosarcoma for 15 months – half her way-too-short life. I think our "halflistic" approach (mixing traditional meds + supplements) helped her thrive. (PM me for details. I'm happy to help.) She had lung mets for over a year. They took her from us in the end, but they cannot take her spirit! She will live forever in our hearts. She loved the beach and giving kisses and going to In-N-Out for a Flying Dutchman. Tripawds blog, and a more detailed blog here. Please also check out my novel, What the Dog Ate. Now also in paperback! Purchase it at Amazon via Tripawds and help support Tripawds!

El Dorado Hills, CA
Member Since:
13 April 2012
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10
18 June 2012 - 3:03 pm
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The hospital will take responsibility, you have pictures, they know what has happened and I am sure they are in butt covering mode about now. That's for a later time, none of that makes Duke better right now. Poor Duke is enduring this because of a human error. It happens, but jeez I just feel for you and Duke right now. All my pawsitive thoughts are coming your way that Duke can pull through this.

All our Best

Suzie and Rizzo

ps I'm so glad you have all those pics for documentation purposes. wow!

Jack Russell born in 2001. Mast cell cancer found Dec 2009 and right rear amputation. Five rounds of chemo done before all treatment stopped. Living life to the fullest!! Read my story at http://rizzo.tripawds.com

New Jersey
Member Since:
27 December 2011
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18 June 2012 - 7:00 pm
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Thinking of you and Duke--hoping that this resolves and he is feeling better soon. I feel so badly that this happened, poor babycrying It sounds like his spirit and spunk is strong and he will fight to keep going.

Joan, Lily's mom

Our beautiful Lily was diagnosed with osteosarcoma in her front leg on 12/14/11 at age 8 and had amp on 12/16/11. She completed 5 rounds of carbo. She was so brave and kicked cancer's butt daily! She lived life fully for 4 years, 3 months, and 15 days after her amp. My angel is a warrior princess. I miss her so much.

dukez
12
18 June 2012 - 7:09 pm
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Just got back from a trip to the oncologist, and ortho surgeon, and another surgeon, and I forget who else looked at him.

The bad news: The hospital administrator just called, who is also a part owner, and they will give me things "at cost". Just since my first visit *after* the problem started occurring. Not even for the bad administration. Then he said he would discount things 50% for me since this happened. So, which is it? At cost or a 50% discount? Or are they the same? In which case that means there is a 50% upcharge. Wow. One thing for sure, the guy was an a**. Of that there is no doubt. If you are in So Cal, let me tell you where NOT to go - except that the doctors are fabulous. And I still say that despite the error.

 

Unfortunately, I also spent $1600 at an emergency clinic other than theirs, and they aren't touching that one, so they aren't really helping much. At all. Wish I'd gone to theirs that time. Oh well, went to a closer one.

 

The owner is blaming it on the drug, not the administration of the drug. Argh... I think I can fight him on that because tons of other dogs should be having this problem if it was a manufacturing problem, not an administration problem.

 

But, I need to stay focused on getting Duke well for now. I can sue him at some later date (and I've never sued anyone, ever). Did I mention he was a jerk?

 

Which leads me to the good news - Duke should pull through. YAY!! clap(Hopefully I can afford to see him through.) They want to see him 2x's week at least for the foreseeable future. They are not going to debride the wound yet because they think more tissue is going to die/damage is going to occur. If they debride, they will want to do that after all the skin has finished dying. My poor handsome baby boy. What a huge setback. As if osteo wasn't enough. Have I mentioned he was born on a Friday the 13th? Seriously. He was. I didn't used to be superstitious. I may need to rethink that. winker

 

So, he is on a boatload of meds (more than post amp!) - and a big dog so, of course, they are pricey:

For potential stomach issues due to all the meds - Prilosec and Pepcid (Famotadine)

Two mega doses of antibiotics to ward off infection - Baytril and Amoxicillin

Three pain meds (because it hurts!) - Metacam, Tramadol, and Gabapentin

Phenoxybenzamine - urinary issues

Pentoxifylline - to help speed healing.

They are going to use the K-laser on the area to help stimulate blood flow to the area. I had thought of that because I have had that used on my old lab-chow mix for her arthritis and it seems to help. I know it is used for wound healing too.

 

That's the update from this corner. I'll keep posting pics as things progress. Sadly, someone else will likely go through this some day so maybe they will be helpful. Unfortunately things are likely to get worse before better, but at least there *is* a better and a future. I love my big handsome boy. aw-shucks

In your heart, where I belong.
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13
18 June 2012 - 7:18 pm
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I don't know all the rules and regulations, but I think you might be able to do a small claims case out of this...as long as you could find another vet (the one who emailed you this morning?) to say that they believe this came about because of the admin problem.

As far as the pricey drugs (I'm just trying to help you keep your shorts, here)--many of those are inexpensive if you don't get them from your vet. The Pepcid and Prilosec can be bought generically anywhere. You can buy it by the literal boatload at Costco or Sam's Club, and also at Target, Walmart, etc. Same with the amoxicillin. If the vet is filling the script for you, tell him you want a paper Rx and take it to a people pharmacy. Ask any parent and they'll tell you that amoxicillin is cheap.

The other stuff I don't know about so much, but I know Tramadol is very cheap. Just make sure a people pharmacy doesn't give you the version with acetaminophen in it (Ultracet). You only want the Tramadol. 

Now for the important stuff: Good luck and happy news! Those born on a Friday the 13th must come with a huge supply of good fortune. Duke is due for some really good fortune.

Shari

From abandoned puppy to Tripawd Warrior Dude, Dakota became one of the 2011 February Furballs due to STS. Our incredibly sweet friend lived with grace and dignity till he impulsively raced over the Bridge on 12-15-12.

Dakota's thoughtful and erudite blog is at http://shari.tr.....pawds.com/

San Diego, CA
Member Since:
29 October 2010
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14
18 June 2012 - 8:16 pm
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Well, I'm so glad to hear there is good news and HOPE for Duke! Hooray!

As for that doctor.... What city are you in? We are in So Cal too (San Diego). I don't know anything about suing or small claims or any of that - but I sure hope that at the very least, karma will get him.

Anyway - treats all around to celebrate the much more pawsitive outlook for Duke!

Jackie, Angel Abby's mom

Abby: Aug 1, 2009 – Jan 10, 2012. Our beautiful rescue pup lived LARGE with osteosarcoma for 15 months – half her way-too-short life. I think our "halflistic" approach (mixing traditional meds + supplements) helped her thrive. (PM me for details. I'm happy to help.) She had lung mets for over a year. They took her from us in the end, but they cannot take her spirit! She will live forever in our hearts. She loved the beach and giving kisses and going to In-N-Out for a Flying Dutchman. Tripawds blog, and a more detailed blog here. Please also check out my novel, What the Dog Ate. Now also in paperback! Purchase it at Amazon via Tripawds and help support Tripawds!

New Jersey
Member Since:
27 December 2011
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15
18 June 2012 - 8:32 pm
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So glad that things have taken a more positive turn--thinking of you and Duke!

Joan and Lily

Our beautiful Lily was diagnosed with osteosarcoma in her front leg on 12/14/11 at age 8 and had amp on 12/16/11. She completed 5 rounds of carbo. She was so brave and kicked cancer's butt daily! She lived life fully for 4 years, 3 months, and 15 days after her amp. My angel is a warrior princess. I miss her so much.

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