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Lung Mets After the Osteosarcoma Vaccine: Any Advice? | Treatment, Recovery and Oncology

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Lung Mets After the Osteosarcoma Vaccine: Any Advice?
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5 August 2018 - 11:55 am
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Hi ! Is anyone out there enrolled in an osteosarcoma vaccine trial? What was your experience? We were encouraged and blessed to be part of this research trial in Texas that gives hope not only to our beloved dogs but humans too! Caesar was diagnosed with osteosarcoma 12/2017. He had his back left leg amputated 12/28/17 and completed 5 rounds of Carboplatin 1/8/18-4/25/18. We entered the OSA vaccine trial 5/2018.  Caesar just completed three osteosarcoma vaccines as of 7/5/18 and did well over all but sadly was diagnosed with lung metastasis end trial 7/24/18. We are devastated but trying to remain hopeful that the vaccine will still offer help. Has anyone been diagnosed with lung metastasis post vaccine? What did you do next? Did you seen benefit from the vaccine after mets? What are our options?  We don't want to pursue harsh chemotherapy with doxorubicin. Our last dog Mugsy went into heart failure from this medication and died. At this time Caesar looks amazing and so we have opted to observe and treat with love and all the yummy food possible so to allow his time left to be enjoyable and happy...however we would be interested to hear what our fellow tripawds are doing elsewhere!

Thank You !

The Rainbow Bridge

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5 August 2018 - 12:17 pm
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Hello Caesar and family, welcome. We are sorry that those mean mets came on so soon after Caesar started the trial, but hopefully it can offer some sort of protection to keep them from growing. 

Has anyone been diagnosed with lung metastasis post vaccine? What did you do next? Did you seen benefit from the vaccine after mets? What are our options?

Honestly the vaccine is so new, that we aren't aware of anyone who has developed mets during or immediately after participating. This also may be in part to the confidentiality clause that participants are bound to while they are in the study. Perhaps we just haven't heard from them yet.

What did your oncologist suggest, other than doxorubicin? I haven't heard of that as a treatment post-metastasis, usually a course of Palladia is suggested, along with metronomics . If your onco thinks doxorubicin is the way to go, keep in mind that all dogs are different and Caesar may respond totally differently to it, in a good way of course. 

If you click on this metronomics link you'll see lots of suggestions for managing those nasty mets, we try to include them as we hear about new methods.

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5 August 2018 - 3:25 pm
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OMD! Ceasar's avatar  picture  is deeeelightful!  That guy has personality  shining through so brightly, he makes us all grin ear ro ear!.

Don't  have any  knowledge per se egarding  your  specific  situation. Jerry has given you some fairly "safe" options that aren't  jnvasive or intrusive  in Ceasar's quality.   That doesn't  mean they don't  have potential  side effects, but they manageable, or the meds can be stopped.

Bur what I can tell you, is clearly  Ceasar is symptom free and that is HUGE!!!  He is being his happy self and not paying any attention  whatsoever  to what the xrays show!!!  Even if symptoms  start to show, there are still wonderful  optio s you have for extended  quality  time.  My Happy Hannah  got some good extended quality  time (and this was even after outward symptoms) with some Prednisone   and some  low dose Tramadol. 

You have  the right attitude...make every day count!!  Don't  waste one second  letting that piece of poopicon_png disease interfere with the blissful days you have ahead!  Be More Dog !

I recently  communicated  with a Vet on the "outward behavior" of my dog, which was far more positive and upliftiting than what the "clinical tests" showed.  She said that my assessment  of his sttitude, engagement  with life, etc, told her far  more about what was going  on with him than the test results.

So point being, Ceasar is telling you categorically that all is well in his world, regardless  what those ole xrays show!  

Okay, this is just a small HINT!  We would loooove to see mpre PICTURES, PICTURES, PICTURES of this handsome fella'!   PICTURES!!!  PLEASE, PICTURES!!!  Okay, maybe that was more than just a "hint"!

Hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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9 August 2018 - 7:43 am
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we are in the boat-- mets discovered during the vaccine. diagnosed 10/10/17, radiation and chemo until amputation was the only path to go on 3/7/18 and then started the vaccine in May. we continued with it knowing there was one met and I reluctantly started palladia as I was told my dog would not survive long without it. we are symptom free, I am giving low doses of palladia after a first dose that was very hard on her. doing supplements and trying to take it day by day. 

would love to hear how your dog is doing post vaccine. 

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