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Clinical trial Experimental EGFR/HER2 Tumor Vaccine
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1 February 2016 - 7:55 pm
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Admin or moderators feel free to move wasn't sure where to post this

Experimental EGFR/HER2 Tumor Vaccine

Study Objective: 
This trial  is evaluating a cancer vaccine strategy for EGFR and/or HER2 bearing tumors in dogs. This stage of the project is simply to determine if anti-tumor antibodies arise in vaccinated animals. The vaccine is composed of a short peptide of canine EGFR (15 amino acids) mixed with LymeVax(R)  (Zoetis) and mineral oil. The patient gets two 0.5 cc vaccines (SC in the nape of the neck) separated by 3 weeks regardless of the size of the dog. Blood samples will be taken at the time of the first injection (Day 0), Day 21 (time of the booster injection), Day 28 (+/- 3 -4 days) and Day 56 (+/- 7 days). Based upon mouse studies, we expect no untoward effects or even injection site reactions.  There are NO contraindications with other forms of therapy, either surgical or chemotherapy. We would prefer mammary tumors and osteosarcomas (and other tumors that are presumed to express EGFR and /or HER2). 
Eligibility Requirements: 
  • any dog with confirmed mammary cancer or osteosarcoma 
  • dogs with any other confirmed cancer may be eligible depending upon enrollment
  • No steroids given within 7 days
  • Performance score of 0, 1, or 2-expected survival time of over 6 weeks
Exclusion Criteria: 
  • Dogs less than 3 kg in body weight
  • Prior steroid use
  • Other clinical findings precluding the use of a vaccine
Compensation: 
This is a partially funded trial. The vaccine and blood draws will be at no cost to the client.
Location of Trial: 
Norwalk, CT

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1 February 2016 - 9:03 pm
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Thanks Michelle.

Folks even though this study originates in CT that doesn't mean you don't qualify if you live out of state. Many times oncologists work with clinical trials in other states, so if you think you qualify don't hesitate to contact the VCC.

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2 February 2016 - 8:52 am
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Another "ray of hope". Thank you Michelle!!!!!!!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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5 May 2016 - 12:34 am
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We live in Maryland and are currently participating in this trial in CT. We received our booster vaccine (day 21) yesterday.  

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5 May 2016 - 8:34 am
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mermaidskis said
We live in Maryland and are currently participating in this trial in CT.  

Welcome and thanks for sharing! Your future forum posts will not require moderation.

Please consider starting a new forum topic or start a free Tripawds blog to provide progress reports about the treatment.

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30 November 2016 - 2:07 pm
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mermaidskis said
We live in Maryland and are currently participating in this trial in CT. We received our booster vaccine (day 21) yesterday.    

Hi, I am new to this site and I saw your post.  I hope all is going well for you.  If you don't mind I would like to see what your thoughts were on the vaccine your dog received.  Any input is much appreciated.  Thank you carol

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30 November 2016 - 4:06 pm
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Hi Carol, thanks for joining. Please consider starting a new topic elsewhere so we can learn about your pup and help however we can. Your future posts won't need approval.

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