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Another REALLY good research piece! What we know about osteosarcoma.
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Mystic, CT
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26 April 2014
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15 January 2015 - 11:30 am
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http://download.....8;ext=.pdf

Fairly easy read. Quite comprehensive. 

 

Mary

Mystic, CT
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15 January 2015 - 1:36 pm
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I apologize the link doesn't work! Let me try something else. It might be a long post however!

mary

Mystic, CT
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15 January 2015 - 1:48 pm
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I am unable unable to post a link to the full article. This is just a summary review. The article discusses a review of all conventional therapy with survival statistics for each. It touches upon therapies that are in the pipeline as well as the efficacy of combination chemo therapies. 

 

I have the full copy. If anyone would like it please message me or email me at rettoc625@comcast.net perhaps the admins know of a way to post the paper more conveniently. 

http://www.ncbi.....d/25422073

Mary

On The Road


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15 January 2015 - 10:39 pm
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Hi Mary,
Thanks for trying. Some journals will not allow republication in any form, unfortunately, but if you'd like to email it to me I would love to review it for my own knowledge. Thanks.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Rio de Janeiro, Brazil
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17 May 2014
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16 January 2015 - 4:21 am
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Thanks for sharing.  I was able to download the pdf in a read-only format.

The results, in fact, are quite similar to what the Tripawds Survey showed: dogs that complete the amputation + carboplatin cycle have longer survival time than those that are treated with amputation alone.

What is still unclear, and perhaps this is where each individual protocol makes the difference, is what to do AFTER CHEMO.  Johnnie's oncologist prescribed nothing at all.  On my own, thanks to Tripawds and Dr. Dressler's book , I introduced K-9 Immunity and Apocaps , and have been following success stories like Charlie the Lab.  I really would like to introduce some metronomic therapy, like doxycicline, but can't do that on my own.

Daniela

Our awesome Golden Boy was diagnosed for OSA in April 2014 in the proximal humerus, front-leg amp on 05/20/2014. Finished chemo (Carbo6) on 07/10/2014. Ongoing treatment: acupuncture + K-9 Immunity Plus ( 3chews) and home-cooked no-grain diet.   Stopped Apocaps because of liver issues.   Liver issues: controlling altered enzymes with SAM-e and Milk Thistle.  October 17:  started having seizures.  Taking fenobarbital for seizures.  April 18: started prednisone.

Mystic, CT
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16 January 2015 - 4:52 pm
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Great Daniela! I am glad you found it! I did a google search of the title to find it and was able to download a free PDF version. Unfortunately I cannot link it for everyone. But I do suggest others do the same or email me and I will send it. 

Whats important is this paper is more than an unscientific survey. It is a review of current therapies and scientific literature published in a veterinary journal. For me it's nice to see complete agreement with data my oncologist has shared with me. It strengthens my trust in his treatment protocol. 

Blazes onc has suggested we can use metronomic  therapy as a maintenance protocol chemo is done. We will see how that goes.

Mary

Mystic, CT
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8 February 2015 - 6:23 pm
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Here is the abstract of the artile I cannot link. 

Mary

 

Vet Res Commun DOI 10.1007/s11259-014-9623-0 REVIEW ARTICLE

What do we know about canine osteosarcoma treatment? – review

M. Szewczyk & R. Lechowski & K. Zabielska Received: 10 September 2014 / Accepted: 13 November 2014 # The Author(s) 2014.

This article is published with open access at Springerlink.com Abstract Osteosarcoma (OSA) is the most common type of bone tumors in dogs, which has high metastasis ability. 80 % of dogs with OSA die due to lung metastasis. As a result its treatment is a challenge for veterinary practitioners. The au- thors discuss the etiology, pathogenesis and the possible risk factors of OSA. The article focuses on literature review and the study of recent advances in OSA treatment. The authors describe therapies which have significantly prolonged the lives of dogs, as well as those that have proven to be ineffec- tive. Advantages and disadvantages of limb amputation and limb-sparing surgery have been described. Authors present also the results of both single agent’s therapies with the most commonly used drugs as cisplatin, carboplatin and doxorubi- cin and compare them to the results obtained using combined chemotherapy. The use of nanotechnology as a new approach in OSA treatment in order to avoid multidrug resistance and reduce negative side effects of cytostatic drugs is presented. The main reasons of the therapies failure are also provided in this article. Keywords Osteosarcoma . Dogs . Treatment . Chemotherapy (Spodnick et al. 1992; Berg 1996; Cavalcanti et al. 2004; Morello et al. 2011). It most often appears in middle age dogs (between 6 and 10 years old) (Thompson and Pool 2002; Morello et al. 2011), but it has also been reported in 1–2 year old dogs (Brodey 1979). The topographic location is the appendicular skeleton (64 % of cases), the axial skeleton (28, 5 %) (ribs and skull) (Fig. 1) and the extraskeletal muscles (7, 5 %) (Calvacanti et al. 2004; Trost et al. 2012). Appendicular OSA appears more often in forelimbs than in hindlimbs, whereas extraskeletal OSA develops primarily in visceral organs (adrenal gland, eye, gastric ligament, ileum, kidney, liver, spleen, testicle and vagina) (Langenbach et al. 1998). Risk factors The ethiopathogenesis of OSA is unknown, but various pre- disposing factors (sex, body weight) may lead to its develop- ment. Dogs with a body weight above 40 kg are more predisposed than smaller dogs (Bergman et al. 1996). Most of the studies indicate that this neoplasm tends to affect males more often than females (Brodey and Abt 1976; Jongeward 1985; Pool 1990; Selverajah and Kirpenstein 2010). However, according to certain reports also females are predisposed. Cooley et al. (2002) indicate that there may be a correlation between castration and a higher risk of tumor development. Male and female dogs that underwent gonadectomy before 1 year of age had a one in four lifetime risk for bone sarcoma and they were significantly more likely to develop bone sarcoma than dogs that were sexually intact.

On The Road


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8 February 2015 - 8:34 pm
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Great article, thank you! I found a URL to the full text here, see if this works.

http://link.spr.....ltext.html

It's a very recent article (last September) which is awesome. Here is the most important part (at least the part that I could understand best with my non-vet mind!):

Conclusions

Canine osteosarcoma is a highly malignant bone tumor in dogs with a high metastasis ability. Nowadays, combining surgery with single agent chemotherapy and radiotherapy seems to be the most effective method of OSA treatment. However, reducing the high metastasis ability and enhancing antitumor activity of cytostatic drugs having minimal negative side effects is still a challenge for veterinary practitioners. New approaches of OSA treatment including the use of nanoparticles are currently under investigation. The results of in vitro studies with fucoidan nanoparticles or dioxide nanoparticles on human osteosarcoma cell lines suggest that they may be a potent new therapeutic agents to treat primary tumors as well as to minimize or prevent the recurrence of OSA . Doxorubicin and siRNA encapsulated in liposome-based dextran nanoparticle could potentially be utilized to develop novel therapies. Many such therapies used in human medicine aimed at stopping metastatic disease could be helpful in dogs with OSA, however, further in vitro and in vivo studies in veterinary medicine are needed.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

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