I always wonder about the dogs I follow and when I do not see anything for weeks my imagination gets the best of me.  So that being said I will give a brief update on Harley.   He just finished two weeks of doxycline which was prescribed in the event his platelets were low due to a tick related disease.  The bloodwork for this ended up being negative and Thursday I took him in for bloodwork to check the platelet count and it dropped another 10,000 and he is now at 30,000.  The oncologist thinks this is probably immune-related platelet destruction and not related to the cancer and recommended he see someone in internal medicine at the facility.  Since it is not oncology related, I am taking him back to his original vet to follow up on this.  I think prednisone is usually the prescribed med for this.  I'm just not sure that I want an ultrasound at this point -- it just seems the more I look the more I find.  Harley continues to be happy and is maybe just a little more tired but I would be too if I was going to the vet this often!  So our journey here began in May when he was scheduled for a limb amp, but that was aborted because two masses were found on his lungs (maybe metastasis, maybe not). Then he was on metronomic chemo for two months this summer and the lung masses were growing slowing and were described as stable.  A good thing so in September he was able to have the tumor debulked again (third time) and just as we were ready to begin another chemo protocol, his platelets dropped unbelievably low, from about 200,000 to 42,000 in 4-5 weeks.  Was it the chemo, was it stress of surgery (surgeon did say there was a lot of oozing this time) or just his bad luck.