And she is on doxorubicin for chemo but at a reduced rate, 75%, because she is MDR1 mutant/normal. 

     I am currently consulting with both her primary vet (also an ortho specialist) as well as her oncologist (who also runs a pet rehab facility). Bella was taking the Previcox and the Gabapentin. After yesterday, she is back on tramadol, and alternating Xanax and Cannapet for the anxiety until we figure if the Cannapet will work as well. We figured her anxiety over all of it was making it worse. The meds are really helping with that part although she is still looking at me like I need to make it better. We are trying to keep her relatively quiet as possible over the weekend. Today was no worse/no better as far as leg weakness and falling. Oncologist believes the biting/licking may be a form of the phantom leg pain . It is believed the cancer started at the same joint on her amputated leg and probably where it was most painful although it spread quickly from there. They both are thinking the leg pain/weakness is probably from sprain/strain from a fall. If she isn't starting to improve by Monday, they are going to bring her back in for re-evaluation as soon as appointment can be made. 

    I know something isn't right but I am not sure how much time to give everything if she did sprain/strain something for it to heal before I start pushing. I keep worrying about misdiagnosis. Her cancer was so difficult to diagnose. We ran test (blood work, xrays, etc) and it was all fine. Although I seriously love and trust my vet, I got two additional opinions. It was my primary that finally caught it. Common sense said it was a leg muscle/ligament injury or the back. We kept trying different things and it was a month or so with trying different things before we finally figured out or that it was able to be detected that one leg was slightly different than the other. Now I feel I am back in the same cycle although her leg symptoms are somewhat different. There is nothing to aspirate and I don't want them to go into her leg to look around. I feel conflicted and frustrated that she is dealing with this. 

     Sorry to vent. Having a very rough dog week/month. My other boy is having complications. With him there is no one to network with. I cannot find anyone that has had his situation although there must be others. There are vets around the country and at colleges following his case. They are trying to figure out if there is anything they can do to help him with his new issues.  

    I would seriously trade places with her if I could. I have had two or more dogs my entire life. I have loved them all deeply but Bella has been "that" dog to me since the day we met. She is by far the most intelligent dog I have ever met. She is intuitive, gentle, and loving. She has literally never, ever done anything wrong since we brought her home. She has never made a mess, chewed anything, had an accident.....nothing.....ever. I think she had to be the good dog to balance my mischievous Golden. Her only shortcoming (to some) is that she is completely submissive and scared of thunderstorms. She also 100% looks to me to protect her - it is not the other way around with her. I have no doubt she would run if a bear was coming at me. So while my other two dogs would roll with it, she waits for me to make her better and tell her things are going to be okay when things go bad.  

Bella update. She has seen three vets (each general with a specialty or specialists) and is on strict "bed rest" for two weeks and on more meds than my grandmother used to be. My Velcro dog is having trouble when she is stuck in a small room instead of right beside me - pain or not. If she is not improving or getting any worse then they will run a ct scan. Hoping for the best..... Just an exhausted dog mom. My other collie is potentially in surgery right now. They are doing a sedated flexibility tests. If he passes, they will do the surgery. If not, we will let him continue as is until he is no longer able to get around.