Thank you for your replies! The interview of Dr. Intile is interesting, but true, things are still pretty much the same with cyclophosphamide and chlorambucil. I'm not sure if any recent research has been made on subject.

Yes, I guess chronotherapy is not yet widely known, and it might even sound like nonsense, but this is what Dr. Dressler says in his book:

"All life forms (dogs, people, worms, plants, algae) share a similar "biological clock", or circadian cycle. As the sun rises in the morning and sets in the evening, certain enzymes turn on and off at appointed times, hormones surge in and out, and organ systems accelerate or slow down.

These processes can all influence the way the body handles drugs. Perhaps, an enzyme that is very active at 10am is helpful in activating a chemotherapy drug - and helpful in suppressing nausea at the same time. Perhaps, a cocktail of hormones is released at that time, which facilitates the drug's absorption into the cancer cells (the mechanisms are not all understood or mapped out yet)".

(Dr. D. Dressler, The Dog Cancer Survival Guide , 2011, pp.139-140).

One can find more information from Internet, including this, more recent article:

https://www.ncb.....MC6927292/

I just wondered that e.g. carboplatin is an alkylating agent too, but it's a platinum drug, while cyclophosphamide and chlorambucil are nitrogen mustards, so do nitrogen mustard drugs work differently than platinum drugs although they all are alkylating agents?