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Caring for a Three Legged Dog or Cat

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Member Since:
7 December 2018
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27 January 2021 - 4:23 am
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I first read about chronotherapy in Dr. Dressler's Dog Cancer Survival Guide and it got me really curious. I have tried to find out a time when chlorambucil would be most effective and least toxic but haven't found this information. I understand that this might be a topic that hasn't been researched at all and I guess the whole field of chronotherapy is still quite underresearched, but I thought I'd ask if anyone's heard anything on the subject.

Dr. Dressler provided some recommended administration times for some chemo drugs in his book, but nothing is said about chlorambucil. I would also like to know if chlorambucil is comparable to some other chemo drug in this regard. I've heard it works similarly as cyclophosphamide, so could they be comparable or is there some other chemo drug that is more similar to chlorambucil?

I understand that this probably isn't the most decisive thing to consider in my dog's cancer care, but I do find the topic fascinating and would love to learn more.

Razbeg the rescue borzoi (born in 11.06.2009) became a tripawd in 20.09.2018.

He and his adopted "brother" Myrsky have their own facebook page:Razbeg & Myrsky


Member Since:
22 August 2008
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27 January 2021 - 8:18 am
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I have never heard of this... as far as I know our local oncologists have not specified a time to give oral chemo unless it has to do with food or the addition of other meds. Chlorambucil is also known as Leukeran if that helps. Yes both chlormabucil and cyclophosphamide are alkylating agents but in general cyclophosphamide is a lot stronger with a different set of side effects (more immunosuppressive and can cause bloody urine).

Pam

On The Road


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24 September 2009
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27 January 2021 - 11:51 am
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Great topic! I can't believe it was in 2013 when we wrote this but it sounds like things are still the same with the two drugs for metronomic chemotherapy :

More About Chlorambucil, Cyclophosphamide for Metronomic Chemotherapy

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Member Since:
7 December 2018
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29 January 2021 - 7:40 am
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Thank you for your replies! The interview of Dr. Intile is interesting, but true, things are still pretty much the same with cyclophosphamide and chlorambucil. I'm not sure if any recent research has been made on subject.

Yes, I guess chronotherapy is not yet widely known, and it might even sound like nonsense, but this is what Dr. Dressler says in his book:

"All life forms (dogs, people, worms, plants, algae) share a similar "biological clock", or circadian cycle. As the sun rises in the morning and sets in the evening, certain enzymes turn on and off at appointed times, hormones surge in and out, and organ systems accelerate or slow down.

These processes can all influence the way the body handles drugs. Perhaps, an enzyme that is very active at 10am is helpful in activating a chemotherapy drug - and helpful in suppressing nausea at the same time. Perhaps, a cocktail of hormones is released at that time, which facilitates the drug's absorption into the cancer cells (the mechanisms are not all understood or mapped out yet)".

(Dr. D. Dressler, The Dog Cancer Survival Guide , 2011, pp.139-140).

One can find more information from Internet, including this, more recent article:

https://www.ncb.....MC6927292/

I just wondered that e.g. carboplatin is an alkylating agent too, but it's a platinum drug, while cyclophosphamide and chlorambucil are nitrogen mustards, so do nitrogen mustard drugs work differently than platinum drugs although they all are alkylating agents?

Razbeg the rescue borzoi (born in 11.06.2009) became a tripawd in 20.09.2018.

He and his adopted "brother" Myrsky have their own facebook page:Razbeg & Myrsky

On The Road


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24 September 2009
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29 January 2021 - 11:27 am
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Hooo boy sounds like we need to get an oncologist on tripawd talk to dive into this topic. You ask some challenging questions! Thanks!

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

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