I'm not a vet, but I do know that Carprofen is an NSAID (also marketed as Rimadyl). Trazodone is not marketed specifically for pain, but it's prescribed for humans for anxiety and depression. It definitely would have the sedative effect that you describe. I think you're seeing the effects of the Trazodone when you say Mona is being "knocked loopy." A study was done in 2014 with the findings of Trazodone promoting calmness in dogs while they were being confined after surgery. 

As Rene said, it may be one of those drugs that you need to withdraw gradually, but I don't know for sure. You might want to tell your vet that Mona is feeling better and ask if it would be okay to wean her from the Trazodone (and be sure to ask if you need to do it gradually). (I think the Trazodone is probably good for keeping post-surgical dogs from being too active.) If the vet's office said she seemed fine without the Trazodone and didn't give her the usual dose while she was in their care, then they might be okay with your taking her off it, especially since she is soon due to get her stitches out, anyway.

As for my own dog, she is now 3 1/2 weeks post-surgery, and she's still taking Meloxidyl (a form of Metacam, which is an NSAID, like Carprofen). The surgeon had wanted her off it four days after surgery because of the risk of side effects from longterm use, but my local vet thought differently and gave us another refill. (I've found that Susie's oncologists, surgeons, surgery residents, veterinary student, and local vet sometimes all have completely different opinions about her recovery care!) The surgeon also prescribed codeine for one week after surgery, then wanted to discontinue it, but the local vet gave us a one-week refill on that prescription, too, so she was on it for almost two weeks.

When she went in for her two week post-op incision checkup and stitches removal, the surgeon (at my request) prescribed Gabapentin to be taken every 8 hours for Phantom Limb Pain. I got the impression she only prescribed it because she felt it would do no harm and I wanted it. The first day I tried giving her just two doses, and she seemed to become very sedated, so from then on, I've only given her one capsule at night. It has helped tremendously, because it was mostly at night that she screamed in pain. 

It's great that Mona is doing so well! I don't think she's a lightweight--I'll bet that Trazodone would make any dog droopy! (That's kind of what it's designed to do!)

Mona sure looks cute in your avatar picture! You guys look as if you make a great team!

((((hugs))))xxx from Nancy & Susie

I agree with everyone else. The Carprofen would help with the pain (although the vet may take her off it, anyway, in a few days when he/she takes her stitches out). It's an NSAID, like Ibuprofen for dogs. It's possible it could be making her a little bit sedated (even Tylenol makes me sedated!), but the Trazadone is specifically for sedation, so that's what's really making her loopy. I don't think it's necessary right now for her to continue taking it--but, just to be on the safe side, you might want to run it by your vet.

I've learned from reading these Forum posts that there is certainly no consensus among veterinarians around the world (or even veterinarians in the same city) as to what drugs to put dogs on after major surgery. My own dog did not get the "standard pain meds" that a lot of dog owners on this site have reported that their dogs received, but there are lots of different drugs that do the same kind of work and each individual case is different. If Mona seems to be doing okay without a boatload of drugs (or any drugs, at this point), she could be fine without them.

Personally, if my dog had bounced back as quickly as Mona seems to be doing, I might call my vet and ask if I could stop giving her the Trazadone. You could also ask about the Carprofen (if she doesn't seem to need it), or you could just wait until the two-week appointment in a few days and then ask (as Mona might be taken off it then, anyway).

My dog actually developed Phantom Limb Pain after surgery, so I asked for (and got) Gabapentin at her two-week checkup. It was too sedating for her to take it every 8 hours as prescribed, so I just give it to her every 24 hours (at night), and she is doing much better on it than before she started taking it.

Also, some of what you're seeing as far as Mona being "droopy" is just a dog's instinct to rest in order to heal. Even when my dog was not in pain, she still slept a lot more after surgery. I believe that the whole experience (spending time in the hospital, etc.) is not only physically painful but also emotionally traumatic (especially to a very sensitive dog with separation anxiety issues), and dogs need lots of downtime in order to recover. Even now, at 3 1/2 weeks post-surgery, my dog (also a right front amputee) will very willingly hop over to her bed and lie down for an hour or so after she feels she's "had enough." And I can tell a big difference in her demeanor if she "overdoes it!"

Good luck to you and Mona in finding the best path to continued healing! We can't really give you more specific advice on these forums, as we're not vets, but it does sound as if Mona might benefit from a change in meds (or possibly no meds at all). Hope you and your vet can work it out!

((((hugs))))xxxx from Nancy & Susie