Such good news!  I'm going to add to this post b/c we had a similar (though less dramatic) issue w/ Ajax.  He had his amputation over 1 1/2 years ago and no issues w/ that,  no spread etc.  He then got a mast cell tumor, which we removed and are now treating.  He did great with the IV vinblastine - no issues whatsoever.  However, we just started are prescribed course of Palladia (after the vinblastine, not together).  It's every other day and by 6 days (i.e. 3 doses) I noticed on more than one afternoon that his back leg seemed very weak.  Then it would seem ok again in the morning.

We were at the vet today for blood work and Palladia check up.  Told her he had been having some digestive issues on the Palladia (lots of gas - like nonstop - and diarrhea.  We talked through that and have ways to address it.  I also mentioned the leg weakness and she thought it was more likely than not that he was just uncomfortable - with his stomach bubbling and gurgling - and couldn't/didn't want to focus oin the leg, or moving pinched or made a gas bubble or something. 

In retrospect this seems right as he was always moving fine in the am before breakfast, but less good after lunch and dinner.

Really?  Thanks Karen - I haven't read that.  That's a useful tip, I'll keep it in mind.

I'm not loving the Palladia experience but can't really clomplain since (a) we had one of the easiest ever recoveries from his amputation; (b) we had no side effects whatsoever from the vinblastine; and (c) all these treatments seem to be successful based on all markers we can meausure. 

Thanks!

They gave us something I can't remember the name of - Tylan?  for the tummy.  Said they like it b/c it doesn't get absorbed into the system.  Sprinkle powder on food.

His Royal Labness rejected it sprinkled on kibble but was pleased to eat it in cottage cheese.  It seems to be helping.