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Prednisone vs. Prednisolone
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Rock Hill, SC
Member Since:
28 November 2011
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29 August 2012 - 7:54 am
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Pam,

Upon learning the cancer was throughout the abdomen, Zeus' vet prescribed Prednisone (20 mg, one tablet daily) to make him feel better in his last days.  He has been on that for 28 days.  When I picked up his refill this morning there was a note that "prednisone is on back order and prednisolone has been substituted - pretty much the same medicine."

I know that you are supposed to wean Prednisone, but since Prednisolone is a metabolite of Prednisone do I need to worry about the substitution?  Today is Dr. R's surgery day and I'm not sure I will hear from him before the first dose is due.

Zeus has really declined in the last couple of days, so I don't know if it really matters but I certainly don't want his last day or two to be miserable.

Zeus was a Husky mix diagnosed with Osteosarcoma at age 11.  A visible lung met and suspicious spot on his liver meant a poor prognosis-six weeks was our vet's best guess. We decided to fight for our boy and his right front leg was amputated on 12/1/11. We did six rounds of chemo, changed his diet and spoiled him completely rotten. We were blessed with 10 great months after diagnosis. Against the odds, the lung met remained a single met and grew very little over those months. A wonderful furbaby with the most gentle spirit, he fought with a strength that we never imagined he possessed. We have no regrets...
http://zeuspod......pawds.com/

Orange County, CA


Member Since:
14 August 2012
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30 August 2012 - 11:19 am
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Hi, 

I know your question wasn't directed at me, but there is no harm in switching from prednisone immediately to prednisolone. They are basically the same drug, as you mentioned, prednisolone is a metabolite of prednisone and therefore works in the same fashion. Prednisolone has a bit less mineralocorticoid effects and I find that some patients have less problems with excessive thirst and urination on prednisolone than they do on prednisone.

Just didn't want you to overly worry until you were able to get a hold of your vet.

(I'm a vet, by the waywinker)

 

I hope Zeus is feeling a little better today, my heart goes out to you both.

Right hind limb amputated 7/3/12 for OSA, started on alternating cycles of Carboplatin and Doxorubicin and oral Palladia. Single lung met 9/1. Met in the neck muscle removed 9/30. Large mass in sublumbar lymph node 10/2. Rescue chemo with ifosfamide 10/6. Mets to the rib and axillary lymph node 10/21. Started Leukeran and Pred 10/25. Wookie left this Earth for a far better place on 12/4/12. I miss you, Boo, you were my heart.

Rock Hill, SC
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28 November 2011
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30 August 2012 - 11:29 am
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Thank you!  I love our vet and can't imagine him substituting if it weren't fine, but I just wanted to be sure.  Thank you so much, again!

Lisa

Zeus was a Husky mix diagnosed with Osteosarcoma at age 11.  A visible lung met and suspicious spot on his liver meant a poor prognosis-six weeks was our vet's best guess. We decided to fight for our boy and his right front leg was amputated on 12/1/11. We did six rounds of chemo, changed his diet and spoiled him completely rotten. We were blessed with 10 great months after diagnosis. Against the odds, the lung met remained a single met and grew very little over those months. A wonderful furbaby with the most gentle spirit, he fought with a strength that we never imagined he possessed. We have no regrets...
http://zeuspod......pawds.com/

On The Road


Member Since:
24 September 2009
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30 August 2012 - 12:40 pm
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wookie524 said
Hi, 

I know your question wasn't directed at me

(I'm a vet, by the waywinker)

Oh my gosh you're a VET? Wowwweeee! So glad to have you here, thanks for taking the time to answer. See my PM to you about how thrilled we are to have you here!

Tripawds Founders Jim and Rene
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