Caring for a Three Legged Dog or Cat
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Hi Pam,
Zeus was prescribed MP (7mg Cytoxan, 5mg Peroxicam, 10 mg Prilosec) every day. After first dose (which we gave with food at 6:00 pm), he got sick and threw up several times. Our vet told us to discontinue until there was no vomiting for 48 hours and then give only Cytoxan every other day for two weeks at which time we will do CBC and re-evaluate to see if he is tolerating it okay and whether we can add in a substitute to the Proxicam. In the meantime I read that Cytoxan should be given in the morning so we gave it with a meal Monday morning and this morning at 6:00 am along with the Prilosec. Both days he seems a bit nauseous (just a little panting and licking) but no vomiting.
Should I be giving the Prilosec at a different time as the Cytoxan to allow it to work before he takes the Cytoxan?
Zeus was a Husky mix diagnosed with Osteosarcoma at age 11. A visible lung met and suspicious spot on his liver meant a poor prognosis-six weeks was our vet's best guess. We decided to fight for our boy and his right front leg was amputated on 12/1/11. We did six rounds of chemo, changed his diet and spoiled him completely rotten. We were blessed with 10 great months after diagnosis. Against the odds, the lung met remained a single met and grew very little over those months. A wonderful furbaby with the most gentle spirit, he fought with a strength that we never imagined he possessed. We have no regrets...
http://zeuspod......pawds.com/
Prilosec works best if taken in the morning about 30 minutes before eating and it does take a few days to kick in. I would give the cytoxan with his food. If the cytoxan is causing the nausea then the dose could be changed or a different drug tried. If he is that sensitive then he probably won't tolerate the piroxicam so you vet might need to change to Metacam which seems easier on the stomach. I tend to use a lot of sucralfate (Carafate) if they are already nauseous because it works fast.
Pam
I am disappointed to say that Zeus does not seem to be tolerating the Cytoxan only. Per vet's instructions we discontinued the Peroxicam and gave him the Cytoxan and Prilosec only on Mon, Wed & Fri of this week. Mon and Wed I could tell that it made him nauseous (light panting and generally didn't seem to feel well). Friday I gave him the Prilosec then 30 minutes later gave him the Cytoxan with his breakfast. Same result through the day yesterday then at 8:00 pm he threw up about 1/2 of his dinner from a couple hours before. Today he just seems to feel bad - lethargic and still a bit nauseous acting.
I will call Dr. R on Monday. In your experience, does a lower dose of Cytoxan provide any benefit against the cancer? Zeus is currently 42 lbs and taking 7 mg Cytoxan. If not, you mentioned other drugs we might try. I would like to do some research on them to be informed when I talk to the doctor on Monday if you don't mind telling me what other options are out there.
Thanks Pam. I really do appreciate your input more than I can tell you.
Zeus was a Husky mix diagnosed with Osteosarcoma at age 11. A visible lung met and suspicious spot on his liver meant a poor prognosis-six weeks was our vet's best guess. We decided to fight for our boy and his right front leg was amputated on 12/1/11. We did six rounds of chemo, changed his diet and spoiled him completely rotten. We were blessed with 10 great months after diagnosis. Against the odds, the lung met remained a single met and grew very little over those months. A wonderful furbaby with the most gentle spirit, he fought with a strength that we never imagined he possessed. We have no regrets...
http://zeuspod......pawds.com/
Oh I'm so sorry! Poor Zeus, he has the most sensitive belly. I hope you, Pam and your vet can come up with a good alternative. Give him a gentle belly rub from us, we hope he feels better soon.
Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet
Poor Zeus. I hope you feel better soon, and get good medical plan going with your doctor!
Poor Zeusy. Hope you get his meds sorted out to something he can handle. Sending pawsitive thoughts his way!
Abby: Aug 1, 2009 – Jan 10, 2012. Our beautiful rescue pup lived LARGE with osteosarcoma for 15 months – half her way-too-short life. I think our "halflistic" approach (mixing traditional meds + supplements) helped her thrive. (PM me for details. I'm happy to help.) She had lung mets for over a year. They took her from us in the end, but they cannot take her spirit! She will live forever in our hearts. She loved the beach and giving kisses and going to In-N-Out for a Flying Dutchman. Tripawds blog, and a more detailed blog here. Please also check out my novel, What the Dog Ate. Now also in paperback! Purchase it at Amazon via Tripawds and help support Tripawds!
Zeus is on a pretty low dose of Cytoxan already. Many oncologists are now using a slightly higher dose of 15 mg/m2 once daily. I had Tazzie on 10 mg/m2 once daily but had to stop due to bladder issues. I kept her on the meloxicam and added artemisinin which she tolerated well.
You could ask your vet about trying Leukeran (chlorambucil) at low daily doses. Most dogs do not have stomach issues from this drug.
Pam
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