Caring for a Three Legged Dog or Cat
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http://www.cout.....rcoma.html
I hope the link works. The article is very technical, but this is very good news. Dr. Couto is a very well respected vet who I knew of from references on this site. He is associated with Greyhounds Rock and used to be with a large vet. teaching hospital. I believe he also treated TJ/greyhound from this site? Jerry, help me out here if I have any of this wrong.
Anyway, about a year ago, Dr. Couto moved to Pennsylvania and joined Metzger Animal Hospital in State College, PA, which is where my Zeus was treated! Unfortunately, his association was well after Zeus had passed, but I was still proud because I just LOVED our vets there. Dr. Couto has long researched OSA and has just released the results from this study. One step at a time, but the vet community is making progress!
Lisa
Zeus was a Husky mix diagnosed with Osteosarcoma at age 11. A visible lung met and suspicious spot on his liver meant a poor prognosis-six weeks was our vet's best guess. We decided to fight for our boy and his right front leg was amputated on 12/1/11. We did six rounds of chemo, changed his diet and spoiled him completely rotten. We were blessed with 10 great months after diagnosis. Against the odds, the lung met remained a single met and grew very little over those months. A wonderful furbaby with the most gentle spirit, he fought with a strength that we never imagined he possessed. We have no regrets...
http://zeuspod......pawds.com/
I wish they would publish in lay man terms I know its good news and I would love to understand what I just read. 
I know its great though. Making progress anyway
Hugs
Michelle & Angel Sassy
Sassy is a proud member of the Winter Warriors. Live long, & strong Winter Warriors.
sassysugarbear.tripawds.com
07/26/2006 - Sassy earned her wings 08/20/2013
05/04/2006 - Bosch, Sassy's pal, earned his wings 03/29/19 fought cancer for 4 months.
"You aren't doing it TO her, you are doing it FOR her. Give her a chance at life."
Wow! Great study and oh so important. I'm surprised they didn't include goldens as well.
The bottom line message I extracted was this: Our analysis of the breeds at high risk for OSA demonstrates that inherited variants are major factors for determining whether a dog develops OSA.
And this: Altogether, the 33 loci identified ..... account for 50% to 80% of the disease risk within each of these three breeds, demonstrating that inherited factors are the pre- dominant cause.
In other words, genetics play a large role in determining whether a dog will develop OSA. Of course, you can have a genetic predisposition to a certain cancer but never express it. There are obviously environmental triggers as well. If we could tease out the genetic vs environmental factors (and most importantly, how they interact) then we would really be on to something. But this is such an important step!
Thanks for sharing Lisa!
Woohoo! Tripawds Rule!
Regulator of the Oaktown Pack, Sheriff of the Oaktown Pawsse, Founding member and President of the Tripawd Girldogs With 2 Names ROCK Club, and ... Tripawd Girldog Extraordinaire!
Thanks LISA !!! And "CODIE RAE for the tramsaltion! Yeah Michelle, Im with y o u....what are they saying??
Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!
Codie Rae said
The bottom line message I extracted was this: Our analysis of the breeds at high risk for OSA demonstrates that inherited variants are major factors for determining whether a dog develops OSA.
Exactly! This is what we took away from the abstract too—that genetic factors and inherited traits are primary factors for dogs developing osteosarcoma.
This is something researchers have known for a while, but the good news is that it appears this study is actually honing in on specific chromosomes and genomic regions to potentially target for therapeutic options...
The association of glutamate receptors with OSA in both dogs and humans suggests glutamate signaling as a potential therapeutic target, although the diverse physiological functions of this pathway could make this difficult.
Good news and bad...they've apparently identified regions to target for potentially fighting the disease, but it may be very difficult to develop therapies using those targets.
While this is very technical, it seems like a step forward in the fight against cancer. And, the discussion about relative human OSA lines comes with good timing, considering our recent Tripawd Talk Radio episode...
Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet
Sooooo....are we at a point where we can actually do a "test" yet to determine any of these factors our dogs may have? Of course, with no real "treatments" developed yet to prevent it, guess it may not be something we'd want to know anyway.
When we belong to this site, one thing really seems to stand out...this blankety,-blank disease does not seem too breed specific at all. And now we're seeing more and more kitties with it too. I know we may see certain breeds more often, but how does that explain the mixed breeds, the other breeds, the cats, etc. Guess that's where enviornmental comes in? Ugh...just so frustrating. Seems like understanding the cause and being able to do something about it is still not within our reach anytime soon.
Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!
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