Tuxedo, a rear leg amputee has no problems zooming around on bare hardwood floors and relatively slick ceramic tile.  At first I put throw rugs down anticipating issues but later discarded them. Turns out the rugs themselves became the issues.  My cats, both the three legged and the four legged one would run and jump on the rugs, riding them as they skimmed across the floor, think bobsled type of thing, until they piled all of the rugs up against the far wall.  Humorous now, a bit upsetting at the time.  So depending on how fast Margaret moves, it would probably be wise to anchor the rugs because even rubber backed rugs "will" slide when a fast moving cat pounces on them.

If rug bobsledding is not likely, then I would definitely look into yoga mats or those rubber foam puzzle flooring blocks (made for kids) as those can be easily cut to fit in just about any exposed area of flooring.  (example kid's foam tiles)  While not cat related, I put down some trimmed foam blocks in my kitchen because I love to cook and find standing for a couple hours at a time to be tiring on the back and feet.  So there might be some other benefits too.