TRIPAWDS: Home to 25292 Members and 2183 Blogs.
HOME » NEWS » BLOGS » FORUMS » CHAT » YOUR PRIVACY » RANDOM BLOG

Tripawds Three Legged Dog & Cat Forum Archives

Tripawds is your home to learn how to care for a three legged dog or cat. Explore 17+ years of forum archives for stories and answers to questions about dog leg amputation, and cat amputation recovery. Enjoy fresh discussion and connect with members in the new Tripawds Support Circle.

JUMP TO FORUMS

Forums Locked: Search archives for answers & join Tripawds Support Circle to keep discussion going!

Avatar
Please consider registering
Guest
Search
Forum Scope


Match



Forum Options



Minimum search word length is 3 characters - maximum search word length is 84 characters
Lost password?
Read Only: Use Search to find 18+ years of member discussons!
sp_Feed sp_PrintTopic sp_TopicIcon-c
CBD and Osteoarthritis
This forum is locked
Avatar
On The Road


Member Since:
24 September 2009
sp_UserOfflineSmall Offline
1
8 June 2020 - 9:58 am
sp_Permalink sp_Print sp_EditHistory

I want to keep this topic going for new studies about CBD and osteoarthritis in pets that get published, in an effort to share accurate, science-based information about CBD for pets, as well as name companies whose CBD pet products have been clinically-studied. Here's the first post:

A collaboration between Baylor University in Texas, Medterra CBD and Sunset Animal Hospital in Houston:

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain

Abstract: Over the last 2 decades, affirmative diagnoses of osteoarthritis (OA) in the United States have tripled due to increasing rates of obesity and an aging population. Hemp-derived cannabidiol (CBD) is the major nontetrahydrocannabinol component of cannabis and has been promoted as a potential treatment for a wide variety of disparate inflammatory conditions.

  • Here, we evaluated CBD for its ability to modulate the production of proinflammatory cytokines in vitro and in murine models of induced inflammation and further validated the ability of a liposomal formulation to increase bioavailability in mice and in humans. Subsequently, the therapeutic potential of both naked and liposomally encapsulated CBD was explored in a 4-week, randomized placebo-controlled, double-blinded study in a spontaneous canine model of OA.
  • In vitro and in mouse models, CBD significantly attenuated the production of proinflammatory cytokines IL-6 and TNF-α while elevating levels of anti-inflammatory IL-10.
  • In the veterinary study, CBD significantly decreased pain and increased mobility in a dose-dependent fashion among animals with an affirmative diagnosis of OA.
  • Liposomal CBD (20 mg/day) was as effective as the highest dose of nonliposomal CBD (50 mg/day) in improving clinical outcomes. Hematocrit, comprehensive metabolic profile, and clinical chemistry indicated no significant detrimental impact of CBD administration over the 4-week analysis period.
  • This study supports the safety and therapeutic potential of hemp-derived CBD for relieving arthritic pain and suggests follow-up investigations in humans are warranted.

A good article about this study that puts it into layperson language is here in Science Daily:

CBD improves arthritis symptoms in dogs

After four weeks of daily treatment, owners and veterinarians reported on the condition of the dogs, whether they observed changes in the animals' level of pain, such as changes related to running or gait. The dogs' cell blood count and blood indicators of liver and kidney function also were evaluated before and after the four weeks of treatment.

"We found encouraging results," Halpert said. "Nine of the 10 dogs on CBD showed benefits, which remained for two weeks after the treatment stopped. We did not detect alterations in the blood markers we measured, suggesting that, under the conditions of our study, the treatment seems to be safe."

I'll try to remember to keep this topic going with other studies, feel free to add any you come across.

For other information about studies and companies with studied products, be sure to check out our Tripawds Nutrition Blog for all posts about CBD in pets.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

Forum Timezone: America/Denver
Most Users Ever Online: 946
Currently Online:
Guest(s) 282
Currently Browsing this Page:
1 Guest(s)
Member Stats:
Guest Posters: 1292
Members: 18750
Moderators: 4
Admins: 3
Forum Stats:
Groups: 4
Forums: 24
Topics: 18945
Posts: 259686
Administrators: admin, jerry, Tripawds
Tripawds is brought to you by Tripawds.
HOME » NEWS » BLOGS » FORUMS » CHAT » YOUR PRIVACY » RANDOM BLOG