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Soft Tissue Sarcoma: Pros and Cons of Radiation?
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22 October 2015
10:21 am
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6 October 2015
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 Hi all! First and foremost, this blog has been so helpful during this entire process so thank you everyone! I need help deciding whether or not radiation will be worth it in Roscoe's case or is it just overkill with dangerous side effects?

Roscoe had an amputation for his soft tissue sarcoma (STS) and it went great! It was a rather large tumor, Grade 2 (not the worst, not the best). Basically, the majority of the margins were clean! Except one part received a 'clean but close' margin of .2 cm (2 mm) from the margin line (not from the tumor), keeping in mind, margins shrink at the pathologist. Most of the literature says that clean but close margins are considered 1mm from the margin...some says closer to 3 mm from the margin. So Roscoe falls right on the cusp if I understand correctly?

Option 1: Radiation 

- Expensive (over $6,000), 18 days of anesthesia (can be dangerous in itself) and radiation, possible side effects from radiation (which are more likely to be seen in a young dog like my Roscoe, who is only 3.5 years!) Also, I think the whole process would stress Roscoe out, he's an emotional fella!

-PRO: Most of the literature says that STS, treated surgically and followed with radiation have a 75% success rate and 5+ year survival rate. 

Option 2: Wait and See plus a Homeopathic Approach

- From the research articles I have read, the chance of a Grade 2 STS returning with unclean margins hovers around 34%, with clean but close, slightly less! So, technically it's giving us the same chance as radiation- around a 75% chance it will not come back PLUS no risk of side effects from radiation. STS also have fairly low metastatic rates (17%) 

- The con is that if it does come back, it will be slightly harder to treat then the first time, definitely would require another surgery and radiation. It's really a coin toss. 

My personal vet, who always leans toward a homeopathic approach, says that most of the time, surgery is curative for STS, regardless of margins. I went a lot deeper and read all of the research articles listed in the Dog Cancer Survival Guide and the oncologist obviously recommends radiation as the "safest" course of action (I take that with a grain of salt). I have him on Apocaps , 50% Origen dog food and 50% Dog Cancer Diet. I also have an appointment with an Eastern Medicine doctor. 

I'm having a hard time understanding the difference between his 70% chance of it not coming back and the radiation giving him a 70% chance 5+ year survival rate? Also, 18 days of anesthesia and radiation kind of seems dangerous, with other bad side effects including a radiation-related tumor, and stressful? I want to do what's best for Roscoe no matter what! Any advice would be greatly appreciated!! Also, any alternative treatments?? I would be very interested in that as well!

Thank you so much!

Kristin & Roscoe & Family

 

 

Kristin & Roscoe & Family

22 October 2015
10:52 am
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Hi Kristin,
I'm not sure when our fairy vet mother will see this but in the meantime I answered your post in "Treatment" so I hope it helps.

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

23 October 2015
11:54 am

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I agree that most cases of STS respond to surgery alone if the margins are even close to clean.  Did the mass grow quickly?  Did the biopsy report say anything about number of mitotic figures per field?  The higher the number the faster the tumor can grow.

My personal choice would be to closely monitor the site and if anything re-grows do surgery ASAP and follow with radiation then.  I would give some sort of mushroom supplement as well as high doses of fish oil.

Pam

24 October 2015
8:51 pm
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tazziedog said
I agree that most cases of STS respond to surgery alone if the margins are even close to clean.  Did the mass grow quickly?  Did the biopsy report say anything about number of mitotic figures per field?  The higher the number the faster the tumor can grow.

My personal choice would be to closely monitor the site and if anything re-grows do surgery ASAP and follow with radiation then.  I would give some sort of mushroom supplement as well as high doses of fish oil.

Pam

Hi Pam!

Thank you so much for your response. It actually makes me feel really great because that is the exact diet/supplement plan and the same logic I've been leaning toward. My personal vet also agrees with you! His mitotic index was 10 which my vet says isn't too bad--your thoughts? We aren't really sure how long it took to grow, minimum one month because that's when it seemed really enflamed and I realized it wasn't just a bite or normal swelling. It my mind it "popped up out of no where" but I've read that it could have been growing slowly for a while...

My plan now is to: consistently feel the area for any small bumps, be obsessive about his diet, mushroom supplements, and lots of fish oil (according to a plan given by my vet). 

Again, can't thank you enough for taking the time to respond!

Sincerely, 

Kristin & Roscoe (and our family)

25 October 2015
10:43 pm

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In general a mitotic index less than 15 is considered low.

Your plan sounds great!

Pam

6 December 2015
3:14 pm
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hello I saw this while posting something about my girl, Im sorry Im not a vet so I know i shouldnt be answering this and its about a month old. but just a suggestion that ALOT of vets dont know about yet, as not one of my girls knew of this. My girl has a front leg amputation due to OSA but this year she had a STS grade 3 very high mitotic index and I did some research and there is a new treatment ECT (electrochemotherapy ) minimal to no side effects except some tenderness at the site, usually done under sedation and takes like 20 mn max. Its very non invasive and since the chemo levels are so low you dont get the chemo side effects. and it can be done on and off over time if needed to control teh site. I was told that radiation doesnt have the best effects on STS, so Id be chancing it anyway. She is 7 months with it at bay.. just something for you to look into.. not alot of places are doing it as they deem it experimental mostly because theres not large studies on it, but multiple small studies that all have been successful.

Angel Neka

7/4/2003-4/5/2016

2.5yr 3x cancer warrior survivor

6 December 2015
6:38 pm
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Not a problem sharing your feedback, we're all about exchanging ideas here so thanks!

Tripawds Founders Jim and Rene
tripawds.com | tripawds.org | bemoredog.net | triday.pet

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