Tripawds Three Legged Dog & Cat Forum Archives

…you for your feedback. The lomustine wiped him out for the last 2 days, lots of sleeping. But he is eating fine with no other side effects. As all of you on here know and are sharing,

…did 6 rounds of lomustine and handled it surprisingly well. Other than just being a little lethargic the last 2 months no other real side effects that we noticed.

…Pug Maggie had Mast Cell cancer- lost her back leg to a MCT in her knee.

Her chemo regimen was actually both lomustine and vinblastine, alternating dose given every other week.  You can read about her chemo in her blog, the link is 'Amputation and Chemo' in my…

…signature below.  According to the notes in my blog post Mag had reactions to vinblastine but not lomustine. 

Our oncologist called mast cell the most unpredictable cancer she treated, that was my experience with multiple tumors over two Pugs.  Mag lost

…to find the right therapy to manage that cancer.

MCT is about the 2nd most common cancer here, you're in good company. Many folks have tried lomustine, a forums search like this can show you some of their stories:

https://tripawd.....;include=1

…we had another surgery last week for removal of an 8cm spot. Came back Grade 2 high mast cell. So they are changing his chemo to lomustine, he's had 4 weeks of vinblastine and prednisone. Looking for feedback from others whose dogs have been on this and your experience. I also have him

…was diagnosed with Histiocytic sarcoma on her front leg at 10 yrs old. We had to amputate and we choose chemo which she did 6 rounds of Lomustine with very little side effects other then a little rundown towards the end of it. At four months she had a tumor come back at the removed lymph node

…they gave her 6 to 9 months, Mag lived almost 4 more years and did not pass from mast cell cancer.

Mag's chemo consisted of two drugs: CCNU or Lomustine, an oral drug, and Vinblastine, an IV drug.

She was on prednisolone throughout chemo and then about a 7 week taper until she was off that med-

…Coco with her first dose(Lomustine) on Wed Feb 9th. So far so good no side effects yet. They did say it could take 3-5 days though, if she were to have any. They did say her liver

…gosh yes we have a lot of members who have used it for histiocytic sarcoma treatment. See these Forums search results for Lomustine and these for CCNU.

I don't have firsthand experience with this so I hope others will chime in. I can also connect you to Murphy's mom who I know

…got some answers: Angel has been diagnosed with progressive histeocytic sarcoma (what a mouthful) and we started chemotherapy that same day (lomustine). She's been handling it like a champ, with the exception of continued litterbox issues (butt hanging over, just going right next to it). She's

…- but we are awaiting bloods to check internal impacts. Outwardly he is coping with it very well, but he's only had one dose! He is also on oral lomustine.

Personally I think its worth it - all your thoughts went around mine and to some extent, still do, but hopefully getting him out of bone pain

…so high that she switched to cytoxan.

   Would she rotate leukeran with palladia? ( as she does with cytoxan)

Dr Sue also spoke of low dose lomustine.

   At this date,, is that something that can be used in place of one of the other meds?

 Cystitis:

  I know it occurs mostly in females..

…s what he said:

1. Thalidomide - Drug was designed to be used in pregnant women originally, he has no experience using this drug in dogs.

2. Lomustine - this is a pure IV chemo drug. 

Normally, the first choice (because it causes less side effects, its is safer and there are more studies…

…published) is carboplatin, second choice is doxorubicin and third choice is lomustine.

All three are classified as first line chemo treatments.

Lomustine is usually considered if there are significant side effects with one of the…

…and doxorubicin in separate sessions for that same purpose (I believe that was the case of Manni in Germany, if my memory is not failing me). 

Lomustine is also used in paliative care, ie when metastases are present or the patient is terminal. 

In these specific situations, lomustine will be

…Luke 🐾

I will try to call Eurydice's vet today to ask further info on thalidomide, lomustine plus your questions reg the vaccine. 

Will come back to you as soon as I speak to him.

Hugs and cuddles 😘🐮💫✨🌟🌹

…and thalidomide. 

I also asked him if he considers any of these two a better option than cyclophosphamide. 

I haven’t asked anything concerning lomustine as it wasn’t mentioned here. 

Let’s see what he thinks of what I did ask.

If there are other questions it is probably best to try and make a

…additional question :

low dose lomustine for chemo agent?

…for your reply.  I made notes about doxy being out of favor for the reasons you posted 

await thoughts on:

thalidomide

low dose lomustine

Do the onco vets In Europe still use cycliphodphamide as best practice chemo med?

 Is there a chemo med that is showing any benefit over

…skin to close her leg the first time a second operation was not possible.

Thankfully it was not paining her at the time so we began treatments of lomustine to shrink the lump.  While the lomustine was slowing the growth it was doing more harm than good.  She also has renal failure and thyroid issues so

…you so much for all your advices!

Ben's sutures was removed yesterday, we saw oncologist the same time and started chemo---- CCNU(lomustine). The bad news--- they found lymph node close to incision spot--took biopsy. I don't think surgeon could miss it because of location, so

…dog Izzy is undergoing CCNU (lomustine) and vinblastine treatment. First dose was rough on her about 4 days in, with most noticeable impact about a week later. Based on the CBC done at

…Mix named Charlie who had his left front leg amputated in December of 2015 for high grade histiocytic sarcoma. He had 6 rounds of oral chemo (lomustine) and was doing great until his last oncology check up where they found a small lump on his right front leg. He had the surgery 2 weeks ago and

…in December.  She's had her third dose of chemo now, and there haven't really been any negative side effects.  The drug she's getting is called lomustine.  Her new tumors have decreased by at least half, and are not inhibiting her lifestyle.

We're still very happy with our choice to amputate.  Her

…better after the staples were removed 17 days post op and almost immediately, seemed to be more like her old self.  She had her first dose of CCNU (Lomustine) the same evening and unfortunately, within 36 hours took a turn for the worse...

Amira did not do well with the chemo and it was a terrible

…her incision.  They called today and it, too, was normal and just reacting to her surgery and healing.

They gave her the first round of chemo, lomustine, and finally sent us home.  No reaction so far - we'll see what the first CBC shows in one week.  We'll be doing all of the blood work with our

… Leah's left leg was amputated.  A final biopsy will tell us if the cancer has spread to any lymph nodes.  Oncology recommends 5 rounds of chemo - lomustine or CCNU - each three weeks apart.  We live a couple of hours from the university, so we have been getting phone updates.  Today Leah is up,

…chemo is the way to go. If it is histiocytic sarcoma was it localised or disseminated?  Frodo had it localised and was successfully treated with Lomustine.

… Yep, a biopsy is typically done again when the leg is off. But since nobody can change what happened, it's just best to move forward.

CCNU (aka Lomustine) has been used by quite a few members here so no worries, it's pretty common really. You're just seeing other drugs like carboplatin being

…mast cells in the lymph node removed with her leg.  Stay postitve!

My Maggie had an alternating treatment of Vinblastine and CCNU (also called Lomustine).  You can read about her treatments in her blog, the link is in my signature below. Over all she handled the chemo pretty well. We only needed

…use, plus we started working with Dr Loops, a homeopathic vet who works predominatly with canine cancer patients. We also did 5 round of CCNU (Lomustine) chemotherapy.

At about Tahoe's 13th month ampuversary, I noticed a large, fast growing bump on his rear hind quarter which was unlike all the

…lots os experience (unfortunately) with hystiocytic sarcoma as Tahoe's was found in the right front elbow, hence amp. We did do 5 rounds on CCNU (lomustine) about 3 weeks after the amp and he had his up/downs due to the chemo. From the amp as well we undertook a holistic approach between different