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Should I start metronomics??
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10 July 2018 - 3:18 pm
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Why aren't I calling my vet asking for the metroninic drugs?

  Simon had a ct on Friday which showed no lung mets..  He had 6 chemo treatments as well.

Are there members here who did the amputation.. had the 6 chemo treatments and then did NOT do the metronomic program... ie  CYC cyclophosphamide  plus an nsaid like piroxicam.  

I'm not sure why I don't have the sense of urgency to start this program. Usually I want to do things immediately. and aggressively.  How important is metronomics in my scenario?  ie  assume the cancer hasn't spread and there is no cancer left to spread??  

The Rainbow Bridge

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10 July 2018 - 4:06 pm
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I'm sure there are some members out there who didn't do it after chemo, so hopefully they will chime in.

As for its urgency, that's entirely up to you, Simon and nobody else. Do what feels right and what you can afford, that's the best medicine there is.

It's better to hop on three legs than to limp on four.™
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10 July 2018 - 6:19 pm
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We planned to do metronomics with chemo, but when the vaccine study required no metronomics , we held off.  We now have Casey on metronomic therapy.  We have not done chest X-rays as honestly, we don't know what we'd do differently if we knew about mets.

Has anyone had real success with Palladia?

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10 July 2018 - 7:55 pm
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Don't miss this informative Tripawds News blog post about metronomics and visit any highlighted metronomics link for many more blog posts and forum topics on the subject.

Metronomic Chemotherapy FAQs for Tripawds

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10 July 2018 - 10:46 pm
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thanks for sending me the blog on metronics.. Got me re focused on the goal..

I do like to copy what successful people are doing.

For ex:  Dr Sue rotates cytoxan  ( cyc) and palladia.

She gives the cyc in the morning and next day,, gives the palladia at nite to reduce nausea.

My nsaid will be peroxicam.  ( her to to nsaid)

Is there a way that Dr. Sue can answer these questions:?

She said she prefers leukeran but the price got so high that she switched to cytoxan.

   Would she rotate leukeran with palladia? ( as she does with cytoxan)

Dr Sue also spoke of low dose lomustine.

   At this date,, is that something that can be used in place of one of the other meds?

 Cystitis:

  I know it occurs mostly in females.. and we look for bladder irritation.. If Simon will be going to the vet onclogist monthly for zolendrontate, would it make sense that they can monitor this every month and that will satisfy the risk?  ( Simon loves to get in the car, and when I pick him up after a few hours.. he is very happy.. so this isnt a negative for his well being) 

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10 July 2018 - 11:27 pm
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luke4275 said
Is there a way that Dr. Sue can answer these questions:?

You would need to ask Dr Sue Cancer Vet, we presume that's who you're referring to...Dr Sue Ettinger and her team are not registered members of this site, and likely far to busy to respond here.

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11 July 2018 - 9:30 am
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We did do metronomics for Bruce, we did the amputation and 4 rounds of carboplatin, followed by 6 months of cyclophosphamide and metacam. The only reason we stopped at 6 months was that he was doing great, but I was worried about cystitis and decided we should quit while we were ahead - that was just over a year ago. Bruce is now at 22.5 months post amputation, we haven't done chest x-rays since we stopped the metronomics but so far he's not experiencing any type of ill health or symptoms I would associate with lung mets, such as coughing or difficulty breathing. Of course we have no idea if he's doing so well because of the treatment or just because he's one of the lucky one's who have had a great outcome so far all things considered. 

Virginia
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11 July 2018 - 9:57 am
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YAY BRUCE!!!!!  So glad you chimed in and sooooo thrilled  to hear how well that big boy is doing!!😁

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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11 July 2018 - 10:30 am
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It's wonderful to hear Bruce is doing so well, thank you for the pupdate!

It's better to hop on three legs than to limp on four.™
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6 August 2018 - 5:08 pm
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Today I saw one of the onco vets  I use.. Simon got a zoledrontate treatment today.  I was  there to discuss which meds to choose for metronomics ..  Imagine my surprise that he is not on board with metronomics …  saying that there is plenty of abstract info available but no real data that shows it works..with oseteosarcoma    we agreed that an nsaid like piroxicam is helpful even on its own.. so I got that rx today, and need to think more on whether I want to add the Cytoxan..  I can go back to the vaccine trial vet who prescribes Cytoxan and Lasix.. and I can also ask this vet for the meds and he will write them... I asked him... " if this were your dog.. what would you do?"  reply.. " it's not my dog... . He as treated thousands on metronomics .. but not for osteo..  So... hmmh.  He did remind me that this is an often fatal disease where more than 90% have mets in lungs on or after year one.. Simon is only 6 months out.. he is doing ok  but... I thanked the vet for reminding me this is a tough disease..  I am being a good owner., fun for the dog.. living in the present.. etc.. . holistic vet suggested dock diving and obstacles and nose work,, which is being planned...

Virginia
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6 August 2018 - 9:59 pm
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 Make no mistake about it.  You ARE a good owner and you are an excellent  advocate  for your pal Simon! The amount  of research  you are doing is quite remarkable.   You are to be commended  for doing whatever it takes to help your Simon.

Although that Onco Vet isn't  on board with Metronomics,  there are other Onco Vets who do prescribe it.  Like a lot of things on this journey, sometimes  it jist boils down to what your gut deals you.

  As you already know from being  on this site, statistics  don't  mean much around here.  Simon is thriving and is doing extraordinarily  well, and that's  all that matters. 

Oh, as far as Piroxicam, not  sure the Vet advised  maybe giving  Sulfracate and/or pepcid while he's on it.  It helps protect the tummy.  I had a dog on it and was not told about this.  After some GI upset, he was put on Sulfracate and able to continue  the Piroxicam  with no issues. I think the Piroxicam  can be a good drug  in a lot of cases.

Can't  wait to hear more about Simon doing dock diving  and the nose work too.  That sounds like a fun "team sport" for the two of you. ❤ It's  so much fun spoiling  a dog!!😁

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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6 August 2018 - 10:25 pm
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Thanks for your reply. And  my vetv did not mention suculfrate.  although I do have plenty of it because I had an ulcer problem with simon . I will do further investigation before I start. Thank you for advising me of that

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6 August 2018 - 10:25 pm
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Sufulcrate

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6 August 2018 - 10:40 pm
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I am supposed to give piroxicam with food... When giving the sufulcrate, on an empty stomach, one hour before the piroxicam.., did you then give food with the piroxicam or does the sufulcrate take care of the need for food and you don't give food?  I will ask my vet.. but I  like to know what to expect..   thanks   anyone else use piroxicam with sufulcrate?

Virginia
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6 August 2018 - 11:48 pm
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If I recall, my directions were for the sufulcrate twice a day approximately 11/2  up to    2 1/2 hours BEFORE food. My Vet said there was a little leeway in the timing  before the food.  I probably  averaged  closer to to 2 1/2 hours before...maybe a little more sometimes, sometimes  a little less.   

But yeah, check with your Vet.  

And the Piroxicam was still given WITH food.

His Piroxicam, was once a day and I gave him that WITH  his evening  meal,  approximately  2 - 2 1/2 hrs after his sufulcrate.  SOMETIMES though, it was closer to 1 1/2 hrs ahead.  He did fine on all scenarios. 

Due to various work hrs, etc,  sometimes  he only got the sufulcrate once a day,  and he had no tummy issues.

I must confess, even though the Vet suggested  adding Pepcid as an extra precaution, I never threw that into the mix.  If I recall, that was to be introduced  thirty minutes before the meal.

So that was my experience.  Others ,may have different  scenarios.  It may even be that the sufulcrate isn't  even prescribed  by some Vets to accompany  the Piroxicam. Or maybe only prescribed  IF they start have tummy issues.

Let us know what your Vet says.

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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