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26 April 2018 - 6:42 am
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Well, we just dropped off our beloved dog for a new field trial that is out there.  I have to admit, I'm a bit nervous about this.  The potential side effects are concerning; the potential benefits are amazing.

We're doing this off trial because of another immunotherapy we had used, but are still going to follow the trial requirements so I can't give details.  But all the info is out there.

Anyway, I could really use some feedback right now - encouragement or a last minute "don't do this".  Our dog is healthy with no signs of mets 16 months post diagnosis and 7 months post amputation.  So are we doing the right thing?

Virginia
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26 April 2018 - 9:33 am
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You are making an informed decision for Bree  out of love and hope for extended unlimited  quality time, correct?'  That is ALWAYS the right decision!!!!!  

Hang tight and trust.......

Hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

The Rainbow Bridge

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26 April 2018 - 10:32 am
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Oh my gosh BRAVO! Honestly, you and Bree are doing wonderful things for pets and people alike. If it weren't for courageous decisions like the one you've made, cancer research would be so much further behind. We are all grateful for your participation, THANK YOU!

We hope you will get to report on it at some point. If you'd like to Private Message me, I'd love to find out the name of the trial for my own knowledge and possibly reporting in the Tripawds news blog, if the researchers will allow me to. No worries if you can't say, totally understand.

It's better to hop on three legs than to limp on four.™
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26 April 2018 - 10:56 am
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jerry said
Oh my gosh BRAVO! Honestly, you and Bree are doing wonderful things for pets and people alike. If it weren't for courageous decisions like the one you've made, cancer research would be so much further behind. We are all grateful for your participation, THANK YOU!

We hope you will get to report on it at some point. If you'd like to Private Message me, I'd love to find out the name of the trial for my own knowledge and possibly reporting in the Tripawds news blog, if the researchers will allow me to. No worries if you can't say, totally understand.  

It's a well known trial under field study.  The paperwork just says I can't reference the name, and even though we're doing it off trial, the vet asked we seek to abide by the company's guidelines.

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26 April 2018 - 11:01 am
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benny55 said
You are making an informed decision for Bree  out of love and hope for extended unlimited  quality time, correct?'  That is ALWAYS the right decision!!!!!  

Hang tight and trust.......

Hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!  

benny55 said
You are making an informed decision for Bree  out of love and hope for extended unlimited  quality time, correct?'  That is ALWAYS the right decision!!!!!  

Hang tight and trust.......

Hugs

Sally and Alumni Happy Hannah and Merry Myrtle and Frankie too!  

Yes, absolutely, and thank you!  We're tried to analyze this a hundred different ways, but the bottom line is that there just isn't enough info to "know" what to do.  

So we've been praying a ton (we would do that anyway even if it seemed obvious), and since God has taken care of her this far and has opened up countless doors to get us in this trial... I don't think he'd let this fail, you know?  So really we're doing this more on faith than anything else (though believe me, I've read as many scientific journals on this topic as there are available for free online).

Thank you so much for the support!

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29 April 2018 - 9:38 am
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Hi there 🌸

Oh, you are so right in doing this!

You have done your research and weighed the benefits against the potential side effects and decided you would go for it, I can only say I wish I could still do it for my baby Eurydice 💕🐮💕

The cancer journey is full of ups and downs and we are certainly dealing with a disease where a lot is not yet known.

I totally agree, without people like you research could not progress, it is thanks to you that a cure will be found at some point.

So, let me raise a toast to you, my friend, and thank you with all my heart for taking this one step further, a step I would have loved to take alongside you. 

Sending you and your baby all my love and Angel slobbery kisses from my girl 😘😘🐮💫✨🌟🌹

Eurydice 77kg/170lb Great Dane limping end of April 2016, amputation (right front leg/osteosarcoma) 4 May 2016 6 courses of carboplatin followed by metronomic therapy, lung mets found 30 Nov 2016. 3 courses of doxorubicin, PET scan 26 Jan 2017 showed more mets so stopped chemo. Holistic route April 2017. Lung X-ray 5 May 2017 showed several tennis ball size mets, started cortisone and diuretics. Miss Cow earned her XXL silver wings 12 June 2017, 13 months and 1 week after amputation and 6 1/2 months after lung mets, she was the goofiest dawg ever and is now happily flying from cloud to cloud woof woofing away :-) 

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11 May 2018 - 1:35 pm
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I would love an update on how your pup is doing.  My 7.5 year old baby girl was diagnosed with osteosarcoma a week ago.  Her leg was amputated in April, and we started her on chemo yesterday.  I am contemplating participating in the trial and, at first, it seemed like an easy decision.  The last person I spoke with about it scared me quite a bit and now I'm not sure what to do.  I don't want to put my baby through the possible horrible side effects but I know they are temporary and could result in a major benefit.  I can't handle the thought of losing my girl in a year and want to give her every chance I possibly can but, like you, I am scared.  It might be an easier decision if she were older, but she's still pretty young and I thought I'd have her at least another 5 years.  This is all a horrible shock.  She made it through the amputation great - she never even cried when her femur shattered or afterwards.  She has bad hip dysplasia but aside from periodically limping you wouldn't know she had a problem because she's so tough - so maybe she'll handle it better than I fear?  Maybe the decision will be easier once I see how she manages chemo.  Anyhow, would love to hear what your experience is thus far.  Thanks so much and all the best to you and your fur baby.

Livermore, CA
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11 May 2018 - 4:15 pm
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Hello emmasmom and welcome, your future posts will not have to wait for approval.

Emma is your pup?  Please consider starting your own topic so you can introduce your girl and get feedback for her. 

It's good to hear she made it though the surgery and is doing well as a Tripawd!

Karen and the Spirit Pug Girls

Tri-pug Maggie survived a 4.5 year mast cell cancer battle only to be lost to oral melanoma.

1999 to 2010

 

              Maggie's Story                  Amputation and Chemo

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11 May 2018 - 5:33 pm
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I can't say for sure if this is the one org90 is participating in with their pup, but for those of you curious in learning more, Aratana's AT-014 trial is for a canine osteosarcoma vaccine: http://www.arat...../pipeline/

I emailed for information and got this in reply:

"In December 2017, the United States Department of Agriculture (USDA) Center for Veterinary Biologics granted Aratana conditional licensure for Canine Osteosarcoma Vaccine, Live Listeria Vector (AT-014) for the treatment of dogs with osteosarcoma, one year of age or older. As required by the USDA to progress from conditional to full licensure, Aratana has commenced an extended field study at approximately two dozen veterinary oncology practice groups across the United States as of the first quarter of 2018. Initially, the therapeutic will be made available for purchase only those veterinary oncology practice groups who participate in the study."

There's not a location very near me, but I called the closest one (the company freely offered two options), and got a little more info on the requirements. It's only available to dogs who have had both amputation and completed chemotherapy, and who have clean chest X-rays one week prior to starting, plus bloodwork and urine testing immediately before. It's a series of daylong vaccine administrations -- three shots each three weeks apart, IIRC. The estimated cost that the technician gave me was $800-1000 per visit.

Like some of the earlier posters said, I'm glad you're participating if you're able; any progress we can make toward beating this disease is great, and I'm grateful to you for taking the chance. I hope it works. heart

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11 May 2018 - 7:50 pm
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wabs said
...for those of you curious in learning more, Aratana's AT-014 trial is for a canine osteosarcoma vaccine...

Don't miss the various articles and videos in the Tripawds News bog about the Canine Osteosaroma Vaccine clinical trials:

Get the Canine Osteosarcoma Vaccine Facts

Bowie’s Canine Osteosarcoma Vaccine Experience

AT-014 Canine Osteosarcoma Vaccine Helps Dogs Like Dexter Beat the Odds

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10 June 2018 - 8:51 am
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I somehow missed the conversation here from awhile back.  She is well and just finished the series.  Again, can' share specifics publicly, but from the info I've gathered thus far I'd encourage anyone to consider the trial we did.

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10 June 2018 - 6:48 pm
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I'm glad to hear things have gone well.  Thanks for doing this, for all of us and our furry friends, and I hope the vaccine meets all of your expectations.

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26 July 2018 - 2:32 pm
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First post -- "Utley" did great w/ six rounds of chemo (carboplatin) following left forelimb amputation -- follow up appt. is tomorrow in which we are to discuss clinical trial for AT-014 vaccine.   We are concerned about side effects?   Any input out there?  Also, why are some posts "guarded" - i.e., can't discuss results of trial?

Thanks for any feedback

The Rainbow Bridge

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26 July 2018 - 2:48 pm
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Hi Utley and family, welcome. We hope you'll consider starting a new topic all about Utley so we can follow along. Regarding your question:

We are concerned about side effects?   Any input out there?  Also, why are some posts "guarded" - i.e., can't discuss results of trial?

Your oncologist will explain any potential side effects but basically they are much milder than what most dogs experience during chemotherapy treatments.

Trial participants are not allowed to discuss the results publicly and all experiences are to be kept confidential between the oncologist and the patient so that the overall findings are not skewed or influenced by participants in any way. I encourage you to watch our interview with Dr. Vaughan, who explains everything:

Get the Canine Osteosarcoma Vaccine Facts

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