Hello, it's been a while since I last wrote but I am Peaches' mom.  Her diagnosis of osteosarcoma was on 2 Jul 2011 and amputation happened on 3 Jul 2011.  Since then I have been taking Peaches to Auburn University where she has successfully accomplished six carboplatin chemo treatments. On 9 Dec the Doc's decided to move forward to metronomic therapy and administered piroxicam and cyclophosphamide.  She was doing awesome and two weeks later on 22 Dec, they added Rapamycin and that is when things changed a bit, a lot actually.  She was on all three for about four days and I started to noticed she began to slowly loose her appetite, which is totally not like Peaches.  So I took her to my local vet and they did CBC tests and everything came back normal.  Her white blood cell count was normal.  They gave her two shots of antibiotics and sent us home with a next day follow up appt.  Went back the next day and she was the same, no food or not even an interest in walking she just wanted to lay down all day.  This time at the vet her WBC had doubled and was at 27,000.  So the vet gave her two more shots and sent us home with some antibiotics.  Peaches slept all day and night.  Today, she was 90 percent back to her old self.  She was walking, eating, wagging her tail and talking.  I am relieved but I am worried.  Why did this happen in the first place? Everything was great with the first two meds and it really did seem to change when the third medication was given.  I just get really anxious because I want to save my girl and I as much as I try to understand this awful disease it overwhelms me.  Anyhow, she is off the metronomic chemo for now until she gets back to her happy self, which she is close, and then they will see about starting her back on.  So after the long history, has anyone had any experience with the metronomic therapy that includes the proxicam, cyclophosphamide, and rapamycin? Is it successful? Any issues? Thank you so much, any information would be helpful. 

Marisa