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Morris Funds New PennVet Osteosarcoma Immunotherapy Clinical Trial
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The Rainbow Bridge

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18 April 2018 - 11:47 am
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This just in: 

DENVER/April 13, 2018 – Morris Animal Foundation has awarded a $775,000 grant to the University of Pennsylvania to test a vaccine that could improve longevity and quality of life for dogs with the deadly bone tumor, osteosarcoma. The research team will conduct clinical trials to evaluate a novel immunotherapy treatment which combines a molecule expressed by cancer cells with a modified live form of the bacteria Listeria monocytogenes.  . . . 

Researchers tested the vaccine in a pilot study with 18 dogs. Those that received the vaccine lived more than twice as long as the historical, matched, control group, with median survival times of 956 days compared to 423 days.

The current prospective, controlled, clinical trial, funded by Morris Animal Foundation and performed through the Comparative Oncology Trials Consortium at the National Institutes of Health, will evaluate this novel immunotherapy in 80 dogs at 11 of the top, university-based veterinary centers across the United States.

The study will compare the immune responses and progression free and overall survival of immunized dogs to a group of dogs that received standard of care alone. The study also will address the ability of the immunotherapy to retard metastatic disease in enrolled patients that develop metastatic disease prior to their scheduled receipt of the immunotherapy.  READ MORE

The article doesn't say which 11 teaching hospitals are participating, but here is a link to the PennVet Study:

OSTEOSARCOMA - Use of a Novel Immunotherapy for Dogs with Bone Cancer of the Leg

Further evaluation of the Listeria vaccine in dogs with osteosarcoma.

You can see that the inclusion criteria for dogs is a bit different than the criteria for the latest Canine Osteosarcoma Vaccine.

Inclusion Criteria:

  • Dogs with newly diagnosed OSA who have received no prior treatment for cancer
  • Dogs with OSA of the leg which is amenable to limb amputation
  • Dogs with no evidence of metastasis at the time of enrollment
  • Dogs weighing at least 25kg (55lbs) after amputation
  • Owners are willing to pursue amputation and chemotherapy at Penn Vet

If anyone pursues this study please let us know what you learn. Thanks!

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19 April 2018 - 11:09 pm
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jerry said
This just in: 

DENVER/April 13, 2018 – Morris Animal Foundation has awarded a $775,000 grant to the University of Pennsylvania to test a vaccine that could improve longevity and quality of life for dogs with the deadly bone tumor, osteosarcoma. The research team will conduct clinical trials to evaluate a novel immunotherapy treatment which combines a molecule expressed by cancer cells with a modified live form of the bacteria Listeria monocytogenes.  . . . 

Researchers tested the vaccine in a pilot study with 18 dogs. Those that received the vaccine lived more than twice as long as the historical, matched, control group, with median survival times of 956 days compared to 423 days.

The current prospective, controlled, clinical trial, funded by Morris Animal Foundation and performed through the Comparative Oncology Trials Consortium at the National Institutes of Health, will evaluate this novel immunotherapy in 80 dogs at 11 of the top, university-based veterinary centers across the United States.

The study will compare the immune responses and progression free and overall survival of immunized dogs to a group of dogs that received standard of care alone. The study also will address the ability of the immunotherapy to retard metastatic disease in enrolled patients that develop metastatic disease prior to their scheduled receipt of the immunotherapy.  READ MORE

The article doesn't say which 11 teaching hospitals are participating, but here is a link to the PennVet Study:

OSTEOSARCOMA - Use of a Novel Immunotherapy for Dogs with Bone Cancer of the Leg

Further evaluation of the Listeria vaccine in dogs with osteosarcoma.

You can see that the inclusion criteria for dogs is a bit different than the criteria for the latest Canine Osteosarcoma Vaccine.

Inclusion Criteria:

    • Dogs with newly diagnosed OSA who have received no prior treatment for cancer
    • Dogs with OSA of the leg which is amenable to limb amputation
    • Dogs with no evidence of metastasis at the time of enrollment
    • Dogs weighing at least 25kg (55lbs) after amputation
    • Owners are willing to pursue amputation and chemotherapy at Penn Vet

If anyone pursues this study please let us know what you learn. Thanks!  

Any idea how this is different from the last trial or the field trial that's going on?

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20 April 2018 - 9:46 am
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Well, it's funded for one thing.  It also requires that amputation, chemo, and vaccine treatment all occur at Penn, it focuses on larger dogs (Goldens and up based on the 25 kg requirement), and it will continue to treat dogs who develop metastatic disease during treatment.

The Rainbow Bridge

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20 April 2018 - 11:06 am
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We have an interview request out to PennVet to get some clarification. Stay tuned.

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