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Why is Osteosarcoma so prevalent? | Presentation and Diagnosis

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Why is Osteosarcoma so prevalent?
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5 October 2017 - 9:34 pm
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When I first got Chance's diagnosis of Osteosarcoma (exactly one year and 2 days ago), I poured over all the documentation I could find about the disease. One thing I searched a lot was "what causes osteosarcoma in dogs?". Most of what you find are the following explanations:

* Large breed dogs are 'prone' to it 

* A site of a previous healed fracture 

* Exposure to carcinogens 

* Genetic predisposition 

Now that Chance is gone, I find myself obsessing over that search again. Finding nothing new of course. And I get disheartened when I read about how many dogs have to go through this. Is anyone out there doing the research on the WHY? I know that UC Davis was doing a drug trial for an Osteo treatment for dogs. But again this treats after the fact. And I read that there is a 'vaccine' of sorts in the works... but it is also given after amputation and diagnosis. 

I hope I live to see this dumb disease eradicated. 

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5 October 2017 - 9:41 pm
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Rocky limped (for literally a day before it cleared up) for years before the OSA diagnosis. I suspect his was a fracture that didn’t heal right. 

I’ve thought about posting about his specifics though because, like you, I think about it a lot since Rocky went to the Bridge. 

Screw this disease. I really hope we find a cure soon. 

David and Rocky

Rocky had his right front leg amputated on Valentine's Day 2017 after being diagnosed with osteosarcoma.

He joined the September Saints on September 3, 2017.

He is the toughest, bravest, sweetest and best friend I'll ever know. 

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6 October 2017 - 9:51 am
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 Is anyone out there doing the research on the WHY?

I know this question can make you crazy thinking about it. We have seen osteosarcoma in dogs and cats that aren't 'supposed' to get it (for instance, our Jerry was a mutt, and this disease is supposed to be more prevalant in pure breed dogs). We've seen it in every kind of dog from Chihuahua on up in size. Young, old, you name it. It's so random, and heartbreaking.

The fact is, there are soooo many variables that contribute to cancer, that instead of trying to answer it from a 10,000' foot view (like a needle in a haystack), scientists are trying to answer it from the ground floor via comparative oncology trials. This important research is working to determine what cancer therapies help stop cancer from spreading in pets and people, and at the same time understand why those certain therapies are working. Once they know that they can look at the bigger picture of how to prevent it in the first place. In a way it's like working backwards to find the starting point of an all-out cure for different cancers. At least, that's my non-scientific explanation.

Here are two suggestions that may help you grapple with this. Whatever conclusions you draw, know that you did nothing wrong with Chance's health, you did all you could for that sweetie. I hope these help.

Video Shows How a Pet Cancer Study Can Help People Too

Are We Shortening Our Dogs’ Lives?

It's better to hop on three legs than to limp on four.™
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6 October 2017 - 10:36 am
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Tha ks for your well articulated out explanation Rene.  It makes senseheart

Happy Hannah had a glorious additional bonus time of over one yr & two months after amp for osteo! She made me laugh everyday! Joined April's Angels after send off meal of steak, ice cream, M&Ms & deer poop!

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6 October 2017 - 3:26 pm
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Thank you Rene, I think that pretty much sums it up beautifully !

Sweet Patricia, I was also given the micro fractures explanation as a most likely scenario but in the end truth is we don't really know what caused our adored babies to develop this piece of the crappest crap disease 💩💩

We gotta have faith and wait for scientists and researchers to find a cure, like Rene pointed out. 

It is marvellous that research is being so actively done all over the globe!

It will be too late for 💕Chanceypants 💕and 💕Eurydice 💕 but I am sure they will be cheering madly from above the day their furry pals can be cured!

Oh, and the vaccine you mentioned: Archa's Mom told me they are using it in Canada.

At the end of the day Rene kindly explained to me it is actually a serious of immunotherapy injections administered after Osteo is present.

The same exists in Portugal for limphomas.

I know two dogs that went through that process, one (a Great Dane) did not complete the treatment, she earned her wings after dose 3 😔 but the other (an Afghan Hound) completed the treatment and is completely cancer free and in the most marvellous health and good humour 😄

I, like you, feel extremely personal about Osteo and am very, very interested in knowing as much as I can about it.

Let's keep exchanging all info we can and keep our fingers crossed something significant will develop asap 🤞🏼🤞🏼🤞🏼

Sending you a HUGE 🐻 HUG and tons of cuddles to all fluffies and pawrents 😘😘😘🐮💫✨🌟🌹

Eurydice 77kg/170lb Great Dane limping end of April 2016, amputation (right front leg/osteosarcoma) 4 May 2016 6 courses of carboplatin followed by metronomic therapy, lung mets found 30 Nov 2016. 3 courses of doxorubicin, PET scan 26 Jan 2017 showed more mets so stopped chemo. Holistic route April 2017. Lung X-ray 5 May 2017 showed several tennis ball size mets, started cortisone and diuretics. Miss Cow earned her XXL silver wings 12 June 2017, 13 months and 1 week after amputation and 6 1/2 months after lung mets, she was the goofiest dawg ever and is now happily flying from cloud to cloud woof woofing away :-) 

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6 October 2017 - 3:30 pm
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Thanks for the links. I admit I do have a lot of time on my hands these days as I'm not working and basically sitting around waiting for our baby to arrive (due date 10/15). So maybe that has something to do with my obsessive research. Part of it also stems from, 'what can I do next time to avoid this?' I want to learn as much as I can! 

Maybe I should have been a scientist! I'm glad to know that some research is being done.. to hopefully one day help both humans and dogs. Cancer in any form is a terrible disease and I know there won't ever be a one solid answer as to the whys and hows. But I am hopeful that I will see some answers and progress in my lifetime. 

Thanks friends, 

-Patricia 

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6 October 2017 - 3:38 pm
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😘😘😘🐮💫✨🌟🌹

Eurydice 77kg/170lb Great Dane limping end of April 2016, amputation (right front leg/osteosarcoma) 4 May 2016 6 courses of carboplatin followed by metronomic therapy, lung mets found 30 Nov 2016. 3 courses of doxorubicin, PET scan 26 Jan 2017 showed more mets so stopped chemo. Holistic route April 2017. Lung X-ray 5 May 2017 showed several tennis ball size mets, started cortisone and diuretics. Miss Cow earned her XXL silver wings 12 June 2017, 13 months and 1 week after amputation and 6 1/2 months after lung mets, she was the goofiest dawg ever and is now happily flying from cloud to cloud woof woofing away :-) 

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