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Par osteosarcoma
4 April 2011
11:49 pm
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Has anyone heard this term/type of bone cancer?  My vet called it par osteosarcoma.  I understand this is when the tumor forms outside the bone, but I haven't found any more information.

 

Is it true that this form is slower growing/spreading? 

 

Buddy, my sweet lab/border collie mix was diagnosed last week.  Chest xrays show his lungs are clear.  Amputation is scheduled for this Thursday.

 

All info and advice is welcome and appreciated.

5 April 2011
9:32 am

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I have not heard of this term.  Bone cancer frequently does grow outside of the bone as well as inside.  Do you have a copy of the biopsy report?

Pam

5 April 2011
9:53 am
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Could he be referring to a periosteal (often an intermediate grade tumor) or parosteal osteosarcoma (usually lower grade), as those that can occur in humans?  Both are not that common & a bit difficult to diagnose. 

 

 

SWEET ISABELLE Rescued from Hurricane Katrina 09/17/2005 OSA diagnosed 08/19/2010. L rear leg amputated 08/24/2010         Resection of MCT in R rear leg 01/20/2011 Enjoying Her Fabulous Life at 13!
5 April 2011
7:15 pm
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Thanks tazziedog and littlemanjake, so glad we've got some big brains here! I'm curious to find out what this is.

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5 April 2011
9:56 pm
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I did have it slightly wrong.  It's parosteal osteosarcoma.  I got a copy of the biopsy results today:

 

Microscopic Description:  The sample represents a neoplastic proliferation of chondro-oseous and fibrous stroma.  It is a moderately cellular lesion, populated by fibroblastic type spindle cells, chondrocytes, and osteoblasts.  There are islands of pale staining fibrous stroma, which transitions into lobules of immature hypercellular cartilage, which then transition into spicules of osseous matrix.  The proliferative cells are generally large, with a large oval or rounded nucleus and fine chromatin and attenuated cytoplasm.  There is not a high degree of atypia of pleomorphism.  Mitotic activity is rare (<1/10 HPF).  Cartilage and bone lacunae are large and irregularly spaced, and occasionally occupied by more than one cell.

 

Diagnosis:  Left medial proximal tibia – Parosteal osteosarcoma.

 

Comment:  The clinical and histologic features are consistent with parosteal osteosarcoma.  These tumors demonstrate slow, but continuous growth on the surface of the bone.  In time, the tumor may acquire a more aggressive clinical behavior and will invade the cortex and will extend into the medullary cavity.  Pulmonary metastasis may occur, but only many months after the clinical disease first becomes apparent.

 

Also:  The radiology report on Buddy's chest xray states:  "Significant thoracic abnormalities are not identified.  There is evidence of spondylosis involving the lumbar spine.  Metastatic neoplasia is not identified."

 

I am now going to go look up "spondylosis".

 

The onconologist says there is a real chance of a cure…  I hope, I hope.  Any experience out there?

5 April 2011
10:32 pm
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Thanks for the details. We only found one mention of parosteal osteosarcoma in the forums, here:

A remarkable story – Holly, Black Lab, 6 and a half years young

Hopefully Dr. Pam can provide better feedback. Let us know what else you find out.

"Dogs are born with three legs and a spare."
— Jerry G. Dawg (10/98-10/08)
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6 April 2011
12:31 am

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I have not seen this type of OSA but since the mitotic index is low and the oncologist agrees it looks good for your dog!  Maybe chemo is not warranted, but I would follow your oncologist's advice.

Spondylosis refers to extra bone growth on the vertebral bodies and is often an incidental finding on xrays (dogs are often not clinical).  It has nothing to do with cancer.

Pam

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