Spencer is a 4.5 year old doberman (rescue, so no clue of his history, adopted at 7 months old).  He was diagnosed 5 weeks ago with grade 3 fibrosarcoma and had his left front leg and scapula amputated about 4 weeks ago.  He weighs about 75 lbs now.

Spencer was on Adriamycin, Cytoxin and Vincristine (3 week cycles – first week getting the adria and cytoxin, week 2 and week 3 getting vincristine).  Tomorrow is the last dose of vincristine for his first 3 week cycle.  We have found out that his heart has reduced function, so they are taking him off of the adriamycin and swapping in Methotrexate. 

anyone know anything about this one?  With doing the adria we were going to only do 12 weeks of treatments (four 3 week cycles); but now with the new one we will be doing 15 weeks (so have 12 weeks to go after tomorrow).  He should get 4 doses of the Methotrexate.  (also will get 4 more of the cytoxin, 8 more of the vincristine).

Any questions I should ask the oncologist when we go in tomorrow.  Any side effects that I should be aware of?  Is this a normal drug to use for this type of cancer when adria can't be used?

Amputated 4 weeks ago….sounds like someone has an ampuversary coming up!!! Sorry, no help on your question. But, Monkeycat Belle will have some treats to celebrate Spencer's upcoming ampuversary!!

I don't know about it for dogs, but in people at can cause liver damage (so they should do blood work to check for increased liver enzymes.)  It can also cause some lung problems.  I would ask the vet if any additional monitoring will be necessary once the mtx is added.  And by the way, "HAPPY AMPUVERSARY" Spencer!!